Alpha-Tocopherol May Protect Hepatocytes Against Oxidative Damage Induced by Endurance Training in Growing Organisms

Górnicka, Magdalena; Drywień, Małgorzata Ewa; Frąckiewicz, Joanna; Debski, Bogdan; Wawrzyniak, Agata

doi:10.17219/acem/62922

Cited by 9 publications

(9 citation statements)

References 30 publications

(37 reference statements)

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“…There have been many studies describing the impact of physical activity on the formation of oxidative stress in the muscles that are most involved during physical training [11]. However, effort-induced reactive oxygen forms are also created in other tissues, such as the liver, testes, heart, and lungs [12][13][14][15]. Due to differences in metabolic processes, individual organs respond to the emerging ROS in various ways.…”

Section: Introductionmentioning

confidence: 99%

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

Górnicka

Ciecierska

Hamułka

et al. 2019

Oxidative Medicine and Cellular Longevity

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The effect of α-tocopherol supplementation on adaptation to training is still equivocal. The aim of the study was to determine the effect of training and α-tocopherol supplementation on α-tocopherol and thiobarbituric acid reactive substance (TBARS) concentration in the rat liver, heart, muscles, and testes. Male Wistar rats (n=32) were divided into four groups (nonsupplemented, not trained—C; nonsupplemented, trained—CT; supplemented, not trained—E; supplemented and trained—ET). During the 14-day experimental period, 2 mg/d of vitamin E as α-tocopherol acetate was administered to the animals (groups E and ET). Rats in the training group (CT and ET) were subjected to 15 minutes of treadmill running each day. The α-tocopherol levels in rat tissues were assessed using high-performance liquid chromatography (HPLC). Lipid peroxides were determined by TBARS spectrophotometric method. α-Tocopherol had a significant impact on α-tocopherol concentration in all tissues. Training increased the α-tocopherol concentration in the heart and muscles but reduced it in the liver. Training also caused increased lipid peroxidation in the muscles, heart, and testes; but a higher α-tocopherol content in tissues reduced the TBARS level. The main finding of the study is that impaired α-tocopherol status and its adequate intake is needed to maintain optimal status to prevent damage to the skeletal and cardiac muscles as well as the testes in growing individuals.

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Section: Introductionmentioning

confidence: 99%

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

Górnicka

Ciecierska

Hamułka

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…Gornicka et al demonstrated that endurance training increased oxidative damage in rat livers and decreased concentrations of the antioxidant α-tocopherol. 14 We hypothesize that untrained animals had sufficient antioxidant levels to protect from oxidative stress and subsequent damage after one session of intense exercise. However, antioxidants may have been partly consumed in the trained animals, potentially resulting in more pronounced damage and induction of inflammatory and fibrotic reactions.…”

Section: Discussionmentioning

confidence: 99%

Increased TNF-α and TGF-β concentrations in rat liver after intense exercise

Czarkowska–Pączek¹,

Piekarczyk-Persa²,

Wyczalkowska-Tomasik³

et al. 2018

Pol. Ann. Med.

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A i m : The aim of the present study was to investigate how one session of intense exercise affected liver gene expression and concentrations of tumor necrosis factor α (TNF-α) and profibrotic transforming growth factor β (TGF-β) in untrained and trained rats. M a t e r i a l a n d m e t h o d s : Here we investigated the impact of intense exercise on liver gene expression and concentrations of TNF-α and TGF-β in untrained and trained healthy rats (n = 30 each). The trained rats underwent 6 weeks of endurance training with increasing load. From each group, liver samples were collected before, immediately after, and 3 h after one session of intense exercise. Gene expression was evaluated with quantitative real-time polymerase chain reaction. Protein content was measured by enzyme immunoassay. R e s u l t s a n d d i s c u s s i o n : One session of intense exercise did not influence gene expression at any time point. In trained rats TNF-α and TGF-β was increased immediately after exercise (P = 0.011 and P = 0.009, respectively). The increase in TGF-β persisted 3 h post exercise (P = 0.045). In untrained rats the concentration of TNF-α did not change in any time point, while TGF-β was decreased both immediately and 3 h after intense exercise (P = 0.01 and P = 0.03, respectively).

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“…Alpha-Tocopherol received the most attention among the vitamin E with antioxidant potentials, but some studies suggested that tocotrienols may have different healthpromoting capacities. An increased concentration of alpha-tocopherol in the liver was found to exert a protective effect against oxidative damage in exercise-induced oxidative stress [68]. Also, Alpha-Tocopherol protects cell membranes from lipid peroxidation by superoxide radical anion and lipid peroxyl free radical scavenging [69].…”

Section: Vitamin E and Oxidative Stressmentioning

confidence: 99%

Vitamins as Antioxidants

Sinbad¹,

Folorunsho²,

Olabisi³

et al. 2019

J Food Sci Nutr Res

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Oxidative stress is a significant factor in the development of chronic diseases. An improved antioxidant potential in the body can reduce oxidative stress and prevent or improve disease conditions. Some food nutrients, especially vitamin C, E, and carotenoids are well-known antioxidants; however, other vitamins such as Vitamin K, Vitamin D, Niacin, Pyridoxine and Riboflavin that may have antioxidant potential are usually not put into consideration. This review entails studies that have investigated the antioxidant properties of other vitamins with the known antioxidants inclusive and their effect in reducing oxidative stress. The reviewed studies suggest that other vitamins possess antioxidant nature, and they can improve oxidative stress, ranging from lipid peroxidation, protein carbonylation, and reduction of advanced glycated end-products. Therefore, proper attention should be given to these neglected vitamins in research activities on oxidative stress, nutrition and the management of diseases related to oxidative stress.

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Alpha-Tocopherol May Protect Hepatocytes Against Oxidative Damage Induced by Endurance Training in Growing Organisms

Cited by 9 publications

References 30 publications

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

α-Tocopherol Protects the Heart, Muscles, and Testes from Lipid Peroxidation in Growing Male Rats Subjected to Physical Efforts

Increased TNF-α and TGF-β concentrations in rat liver after intense exercise

Vitamins as Antioxidants

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