Increased TNF-α and TGF-β concentrations in rat liver after intense exercise

Czarkowska–Pączek, Bożena; Piekarczyk-Persa, oanna; Wyczalkowska-Tomasik, Aleksandra; Żendzian-Piotrowska, Małgorzata; Pączek, Leszek

doi:10.29089/2017.17.00008

Cited by 2 publications

(1 citation statement)

References 14 publications

(12 reference statements)

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“…Physical activity in general has a positive effect on metabolic processes, stimulating muscles to actively contract, improving blood circulation, and supplying oxygen [1]. On the other hand, physical activity will also induce stressful conditions, which will subsequently increase cell damage and inflammatory responses in the liver [2,3]. The production of the cortisol hormone marks the occurrence of stressful conditions in the body [4].…”

Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Physical activity in general improves metabolic processes by stimulating muscles to contract actively, improving blood circulation, and supplying oxygen. On the other hand, it will create stressful conditions, which will increase cell damage and inflammatory responses in the liver. This study aimed to determine the effect of forest bee honey supplementation on the expression of HIF-1α, SOD, and TNF-α in rats that underwent the forced swimming test (FST) as a physical stress model. The physical activity conducted is at risk of disrupting to several organs due to the stress it causes in addition to the obtained health benefits. A total of 24 adult female rats were divided into four groups: Control (C) with FST only, (T1) FST and honey 2 g/day, (T2) FST and honey 4 g/day, (T3) FST and honey 6 g/day. A forced swimming test was conducted for five minutes per day for 14 days. The collected liver organs were histopathologically prepared by immunohistochemical staining for HIF-1α, SOD, and TNF-α proteins. The results showed that hepatic HIF-1α and TNF-α expression decreased in the honey-supplemented group, while hepatic SOD expression increased, although all three showed insignificant differences from each other. This study concludes that honey supplementation is incapable of increasing the expression of SOD as well as reducing the expression of HIF-1α and TNF-α in the liver of rats modelled by physical stress.

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Section: Introductionmentioning

confidence: 99%

Untitled

2023

J. Med. Chem. Sci.

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Exploring the Impact of Astaxanthin Supplementation in Conjunction with a 12-Week CrossFit Training Regimen on Selected Adipo-Myokines Levels in Obese Males

Moqaddam,

Nemati,

Dara

et al. 2024

Nutrients

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Objective: Obesity is associated with an exacerbated metabolic condition that is mediated through impairing balance in the secretion of some adipo-myokines. Therefore, the objective of the present study was to explore the impact of astaxanthin supplementation in conjunction with a 12-week CrossFit training regimen on some selected adipo-myokines, insulin insensitivity, and serum lipid levels in obese males. Material and Methods: This study is a randomized control trial design; 60 obese males were randomly divided into four groups of 15, including the control group (CG), supplement group (SG), training group (TG), and combined training and supplement group (TSG). The participants were subjected to 12 weeks of astaxanthin (AST) supplementation [20 mg/d capsule, once/d] or CrossFit training or a combination of both interventions. The training regimen comprised 36 sessions of CrossFit, each lasting 60 min, conducted three times per week. The metabolic indices, body composition, anthropometrical, cardio-respiratory, and also some plasma adipo-myokine factors, including decorin (DCN), activin A, myostatin (MST), transforming growth factor (TGF)-β1, and follistatin (FST), were examined 12 and 72 h before the initiation of the main interventional protocols, and then 72 h after the final session of the training protocol. Results: There was no significant difference in the baseline data between the groups (p > 0.05). There were significant interactions between group x time for DCN (η2 = 0.82), activin A (η2 = 0.50), FST (η2 = 0.92), MST (η2 = 0.75), and TGFB-1 (η2 = 0.67) (p < 0.001 for all the variables). Significantly changes showed for DCN in TSG compared to TG and SG and also TG compared to SG (p = 0.0001); for activin A in SG compared to TG (p = 0.01) and TSG (p = 0.002); for FST in SG compared to TG and TSG (p = 0.0001), also in TSG compared to TG (p = 0.0001); for MST in SG, TG, and TSG compared to CG (p = 0.0001) and also in TSG compared to SG (p = 0.0001) and TG (p = 0.001); for TGFB-1 in SG, TG, and TSG compared to CG (p = 0.0001) and also TSG compared to SG (p = 0.0001) and TG (p = 0.001). Conclusions: The 12-week CrossFit training concurrent with AST supplementation reduced anthropometric and metabolic factors and also serum lipid levels while producing positive changes in body composition and cardiovascular factors. Increased FST and DCN and reduced activin A, MST, and TGF-β1 were other affirmative responses to both interventions.

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Increased TNF-α and TGF-β concentrations in rat liver after intense exercise

Cited by 2 publications

References 14 publications

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Exploring the Impact of Astaxanthin Supplementation in Conjunction with a 12-Week CrossFit Training Regimen on Selected Adipo-Myokines Levels in Obese Males

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