Alpha-thalassemia is associated with a decreased occurrence and a delayed age-at-onset of albuminuria in sickle cell anemia patients

Nebor, Danitza; Broquère, Cédric; Brudey, Karine; Mougenel, Danielle; Tarer, Vanessa; Connes, Philippe; Élion, Jacques; Romana, Marc

doi:10.1016/j.bcmd.2010.06.003

Cited by 46 publications

(36 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous study by Nebor et al showed that alpha thalassemia was associated with a delayed age-of-onset of albuminuria in SCA patients but an association between albuminuria and LDH could not be shown. 20 Levels of hemolysis vary amongst patients with SCA, and the existence of a sub-phenotype of patients with markedly increased hemolysis has been postulated. 8 Patients with high levels of hemolysis have increased mortality, and increased rates of specific sickle complications including pulmonary hypertension, priapism and leg ulcers.…”

Section: Tg Day Et Almentioning

confidence: 99%

Association between hemolysis and albuminuria in adults with sickle cell anemia

Day

Drašar²,

Fulford³

et al. 2011

Haematologica

104

View full text Add to dashboard Cite

We have investigated renal function and markers of hemolysis in a cohort of 424 adult African-British patients with sickle cell disease. While significant associations were found in HbSS and HbSb 0 (sickle cell anemia) patients with and without controlling for covariates between hemolytic markers and albuminuria, the associations were not significant in patients with HbSC. Estimated glomerular filtration rate, a marker of renal function, correlated significantly with reticulocyte count and bilirubin. Alpha thalassemia, present in 34% of the sickle cell anaemia patients, had a protective effect against albuminuria in this group. Altogether, the incidence of hyperfiltration was 71% and microalbuminuria 37%, making nephropathy a common complication of sickle cell anemia. Haematologica 2012;97(2):201-205. doi:10.3324/haematol.2011 This is an open-access paper. ABSTRACTexcluded from the study group if they had a history of diabetes mellitus, HIV infection, malignancy or another cause of chronic kidney disease (CKD) or if they were on a blood transfusion program. Seventeen patients were on ACE (angiotensin converting enzyme) inhibitor or ARB (angiotensin II receptor blocker) therapy; these patients were also excluded from the study. Since 2006, urinary albumin/creatinine ratio (ACR) has been a routine measurement for patients attending the specialist clinic. All patients were routinely genotyped for α thalassemia using a PCR-based methodology on DNA extracted from peripheral blood.17

show abstract

Section: Tg Day Et Almentioning

confidence: 99%

Association between hemolysis and albuminuria in adults with sickle cell anemia

Day

Drašar²,

Fulford³

et al. 2011

Haematologica

104

View full text Add to dashboard Cite

show abstract

“…Regarding haplotypes, the risk of renal failure inSCA is increased in patients who have the CAR beta S-globin haplotype ( 34 ) . The co-inheritance of alpha-thalassemia was associated with a lower prevalence of macroalbuminuria in SCA patients suggesting renal protection ( 35 , 36 ) . No association was found between albuminuria and beta S-globin haplotypes (CAR versus non-CAR haplotypes) ( 35 , 36 ) .…”

mentioning

confidence: 99%

“…The co-inheritance of alpha-thalassemia was associated with a lower prevalence of macroalbuminuria in SCA patients suggesting renal protection ( 35 , 36 ) . No association was found between albuminuria and beta S-globin haplotypes (CAR versus non-CAR haplotypes) ( 35 , 36 ) . An evaluation of the association between kidney dysfunction and haplotypes in 84 Brazilian sickle cell disease patients is published in this issue of the Revista Brasileira de Hematologia e Hemoterapia (RBHH) ( 37 ) .…”

mentioning

confidence: 99%

Sickle cell anemia: clinical diversity and beta S-globin haplotypes

Loggetto¹

2013

Revista Brasileira De Hematologia E Hemoterapia

View full text Add to dashboard Cite

“…Although all patients with SCD have the same mutation, severity of their clinical manifestations are very different from one to another [4]. Some genetic modifiers are identi fied for SCD including alpha thalassemia [5][6][7], ele vated HbF, and glucose 6 phosphate dehydrogenase (G6PD) deficiency. However these factors don't com pletely clarify the diversity in the clinical findings of patients with SCD [6,7].…”

mentioning

confidence: 99%

“…Some genetic modifiers are identi fied for SCD including alpha thalassemia [5][6][7], ele vated HbF, and glucose 6 phosphate dehydrogenase (G6PD) deficiency. However these factors don't com pletely clarify the diversity in the clinical findings of patients with SCD [6,7]. Today, the introduction of genome analysis due to the development in molecular biology has been helpful to identify the genomic poly morphisms responsible for the clinical diversity in SCD.…”

mentioning

confidence: 99%