Alpha Solanine: A Novel Natural Bioactive Molecule with Anticancer Effects in Multiple Human Malignancies

Hassan, Sayyeda Hira; Gul, Sameena; Zahra, Hafiza Sadaf; Maryam, Amara; Shakir, Hafiz Abdullah; Khan, Muhammad Noman; Irfan, Muhammad

doi:10.1080/01635581.2020.1803932

Cited by 21 publications

(19 citation statements)

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“…In 2012, approximately 14 million cancer cases and 8.2 million deaths were recorded 3 . In 2018, the cancer cases and cancer‐associated deaths were increased to 18.1 and 9.6 million, respectively 4 . According to GLOBOCAN estimates, about 19.3 million de novo cases and 10 million deaths have been observed in 2020 5 .…”

Section: Introductionmentioning

confidence: 99%

A comprehensive review on anticancer mechanism of bazedoxifene

Zafar

Maqbool

Iqbal

et al. 2021

Biotech and App Biochem

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Cancer is counted as a second leading cause of death among nontransmissible diseases. Identification of novel anticancer drugs is therefore necessary for the effective treatment of cancer. Conventional drug discovery is time consuming and expensive process. Unlike conventional drug discovery, drug repositioning offers a novel strategy for urgent drug discovery since it is a cost-effective and faster process. Bazedoxifene (BZA) is a synthetic selective estrogen receptor modulator, approved by the United States Food and Drug Administration for the treatment of osteoporosis in postmenopausal women. BZA is now being studied for its anticancer activity in various cancers including breast cancer, liver cancer, pancreatic cancer, colon cancer, head and neck cancer, medulloblastoma, brain cancer, and gastrointestinal cancer. Studies have reported that BZA is effective in reducing cancer progression through multiple mechanisms. BZA could effectively inhibit STAT3, PI3K/AKT, and MAPK signaling pathways and induce apoptosis. In addition to its anticancer activity as monotherapy, BZA has been shown to enhance the chemotherapeutic efficacy of clinical drugs such as paclitaxel, cisplatin, palbociclib, and oxaliplatin in multiple neoplasms. This review mainly focused on the anticancer activity, cellular targets, and anticancer mechanism of BZA, which may help the further design and conduct of research and repositioning it for oncological clinic trials.

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Section: Introductionmentioning

confidence: 99%

A comprehensive review on anticancer mechanism of bazedoxifene

Zafar

Maqbool

Iqbal

et al. 2021

Biotech and App Biochem

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“…The intake of high doses of α-solanine causes vomiting, diarrhea, and cardiac dysrhythmia in humans [7]. Recently, several studies have been reported that α-solanine exerts anti-cancer properties by inducing apoptosis and inhibiting cell growth, migration, and invasion in multiple cancer cells in vitro [8]. Apoptosis, or programmed cell death, is used remove aging and dead cells to maintain and stabilize homeostasis [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo

Yuan

et al. 2021

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α-Solanine, a bioactive compound mainly found in potato, exhibits anti-cancer activity towards multiple cancer cells. However, its effects on human choriocarcinoma have not been evaluated. In the present study, we investigated the effect of α-solanine on cell proliferation and apoptosis in human choriocarcinoma in vitro and in vivo. The results showed that α-solanine, at concentrations of 30 μM or below, did not affect the cell viability of the choriocarcinoma cell line JEG-3. However, colony formation was significantly decreased and cell apoptosis was increased in response to 30 μM α-solanine. In addition, α-solanine (30 μM) reduced the migration and invasion abilities of JEG-3 cells, which was associated with a downregulation of matrix metalloproteinases (MMP)-2/9. The in vivo findings provided further evidence of the inhibition of α-solanine on choriocarcinoma tumor growth. α-Solanine suppressed the xenograft tumor growth of JEG-3 cells, resulting in smaller tumor volumes and lower tumor weights. Apoptosis was promoted in xenograft tumors of α-solanine-treated mice. Moreover, α-solanine downregulated proliferative cellular nuclear antigen (PCNA) and Bcl-2 levels and promoted the expression of Bax. Collectively, α-solanine inhibits the growth, migration, and invasion of human JEG-3 choriocarcinoma cells, which may be associated with the induction of apoptosis.

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“…Further discussion will focus on potato GAs as potential pharmacological compounds because of the significant amount of waste from food manufacturing (70 – 140 tons of potato peels yearly around the world) (besides the broad spectrum of identified biological effects) that is discarded in dumps and leads to ecological problems or is used as low-quality feed for animals [ 26 ].…”

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confidence: 99%

“…The antitumor potential of potato GAs has been demonstrated in many investigations (primarily in vitro ) using activation of mitochondrial pathways of apoptosis or autophagy, delay of the cell cycle, inhibition of angiogenesis and metastasis (by reducing expression of genes coding metalloproteinases, E-cadgerin, etc. ), and induction of lipid peroxidation [ 26 ].…”

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Glycoalkaloids of Plants in the Family Solanaceae (Nightshade) as Potential Drugs

et al. 2022

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Worldwide interest in medicinal plants and related drugs is growing because of the increased spectrum of new synthetic drugs. In this context, secondary plant metabolites are most significant. This review analyzes data on the structures and biosyntheses of metabolites such as glycoalkaloids; methods for their extraction from plants of the family Solanaceae, particularly potato S. tuberosum ; their qualitative and quantitative analysis; biological activity; and toxicity. This information could be useful in the selection of methods for sample preparation and extraction of glycoalkaloids during the search for new plant sources with prospects of creating effective and safe pharmacological agents.

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Alpha Solanine: A Novel Natural Bioactive Molecule with Anticancer Effects in Multiple Human Malignancies

Cited by 21 publications

References 61 publications

A comprehensive review on anticancer mechanism of bazedoxifene

A comprehensive review on anticancer mechanism of bazedoxifene

α-Solanine Inhibits Proliferation, Invasion, and Migration, and Induces Apoptosis in Human Choriocarcinoma JEG-3 Cells In Vitro and In Vivo

Glycoalkaloids of Plants in the Family Solanaceae (Nightshade) as Potential Drugs

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