Alpha Rhythm Power and the Effect of Photic Stimulation in Migraine with Brain Mapping

Tsounis, S.; Varfis, G.

doi:10.1177/155005949202300103

Cited by 6 publications

(11 citation statements)

References 13 publications

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“…More specifically in migraine, increased alpha power has been recorded in posterior brain regions, while activity in the frontal lobe has revealed decreased activity in alpha generators (Clemens et al, 2008; Cao et al, 2018). Other studies have also reported on a global inter-ictal decrease of EEG activity (Tsounis and Varfis, 1992; Cao et al, 2016) and on an association between slower alpha activity and greater disease and attack durations (Bjørk et al, 2009). Whereas in FM, decreased alpha, increased beta (Vanneste et al, 2017) and augmented theta activity (Fallon et al, 2018) have been found in different cortical areas and have also been reported to positively correlate with clinical symptoms.…”

Section: Abnormal Eeg Responses As a Shared Mechanism For Smd And Painmentioning

confidence: 91%

Sensory Modulation Disorder (SMD) and Pain: A New Perspective

Bar-Shalita

Granovsky

Parush

et al. 2019

Front. Integr. Neurosci.

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Sensory modulation disorder (SMD) affects sensory processing across single or multiple sensory systems. The sensory over-responsivity (SOR) subtype of SMD is manifested clinically as a condition in which non-painful stimuli are perceived as abnormally irritating, unpleasant, or even painful. Moreover, SOR interferes with participation in daily routines and activities (Dunn, 2007 ; Bar-Shalita et al., 2008 ; Chien et al., 2016 ), co-occurs with daily pain hyper-sensitivity, and reduces quality of life due to bodily pain. Laboratory behavioral studies have confirmed abnormal pain perception, as demonstrated by hyperalgesia and an enhanced lingering painful sensation, in children and adults with SMD. Advanced quantitative sensory testing (QST) has revealed the mechanisms of altered pain processing in SOR whereby despite the existence of normal peripheral sensory processing, there is enhanced facilitation of pain-transmitting pathways along with preserved but delayed inhibitory pain modulation. These findings point to central nervous system (CNS) involvement as the underlying mechanism of pain hypersensitivity in SOR. Based on the mutual central processing of both non-painful and painful sensory stimuli, we suggest shared mechanisms such as cortical hyper-excitation, an excitatory-inhibitory neuronal imbalance, and sensory modulation alterations. This is supported by novel findings indicating that SOR is a risk factor and comorbidity of chronic non-neuropathic pain disorders. This is the first review to summarize current empirical knowledge investigating SMD and pain, a sensory modality not yet part of the official SMD realm. We propose a neurophysiological mechanism-based model for the interrelation between pain and SMD. Embracing the pain domain could significantly contribute to the understanding of this condition’s pathogenesis and how it manifests in daily life, as well as suggesting the basis for future potential mechanism-based therapies.

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Section: Abnormal Eeg Responses As a Shared Mechanism For Smd And Painmentioning

confidence: 91%

Sensory Modulation Disorder (SMD) and Pain: A New Perspective

Bar-Shalita

Granovsky

Parush

et al. 2019

Front. Integr. Neurosci.

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“…A ratio lower than 1 may be an indicator of the disturbance of neuronal excitability of the visual cortex common in migraine (1,10,12,13,15). We conclude that the ratio obtained from GFP data may provide stable parameters and reproducible results.…”

Section: Discussionmentioning

confidence: 77%

“…Further investigation will be needed to obtain comparable ratios from patient EEG data. Within this context, migraine and headache patients will be of special interest, since previous studies along with preliminary findings in our clinical experience suggest that migraine patients show significantly different electrophysiologic patterns of reaction to IPS with a flashlight in comparison to healthy controls (10,12,15). Within this context, missing suppression or even an activation of brain waves during 20-Hz IPS is to be expected in migraine patients.…”

Section: Discussionmentioning

confidence: 91%

“…0.3 0.4 0.5 0.6 0.7 0.8 0.9 1.0 Ratio patients compared local EEG changes above single electrodes (10,12,15) and revealed a decrease of power at single occipitoparietal electrodes induced by 20-Hz IPS in normal healthy volunteers. In the present study, GFP was employed as a criterion which integrates data gained from all surface electrodes.…”

Section: Discussionmentioning

confidence: 99%

“…Apart from PDE, the phenomenon of alpha-suppression has been explored by several investigators, who reported differences between headache and migraine patients: IPS at rates of 20 Hz in patients suffering from migraine did not lead to the alpha-suppression which occurs in healthy volunteers. In some patients IPS elicited even an activation of brain waves similar to PDE (10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Uniform decrease of alpha-global field power induced by intermittent photic stimulation of healthy subjects

Rau

Raschka

Koch³

2002

Braz J Med Biol Res

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Nineteen-channel EEGs were recorded from the scalp surface of 30 healthy subjects (16 males and 14 females, mean age: 34 years, SD: 11.7 years) at rest and under trains of intermittent photic stimulation (IPS) at rates of 5, 10 and 20 Hz. Digitalized data were submitted to spectral analysis with fast fourier transformation providing the basis for the computation of global field power (GFP). For quantification, GFP values in the frequency ranges of 5, 10 and 20 Hz at rest were divided by the corresponding data obtained under IPS. All subjects showed a photic driving effect at each rate of stimulation. GFP data were normally distributed, whereas ratios from photic driving effect data showed no uniform behavior due to high interindividual variability. Suppression of alpha-power after IPS with 10 Hz was observed in about 70% of the volunteers. In contrast, ratios of alpha-power were unequivocal in all subjects: IPS at 20 Hz always led to a suppression of alpha-power. Dividing alpha-GFP with 20-Hz IPS by alpha-GFP at rest (R = a-GFP IPS /a-GFP rest ) thus resulted in ratios lower than 1. We conclude that ratios from GFP data with 20-Hz IPS may provide a suitable paradigm for further investigations.

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Lack of cold pressor test-induced effect on visual-evoked potentials in migraine

Coppola

Currà²,

Serrao

et al. 2009

J Headache Pain

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In patients with migraine, the various sensory stimulation modalities, including visual stimuli, invariably fail to elicit the normal response habituation. Whether this lack of habituation depends on abnormal activity in the sub-cortical structures responsible for processing incoming information as well as nociception and antinociception or on abnormal cortical excitability per se remains debateable. To find out whether inducing tonic pain in the hand by cold pressure test (CPT) alters the lack of visual-evoked potential (VEP) habituation in migraineurs without aura studied between attacks we recorded VEPs in 19 healthy subjects and in 12 migraine patients during four experimental conditions: baseline; no-pain (hand held in warm water, 25°C); pain (hand held in cold water, 2–4°C); and after-effects. We measured P100 amplitudes from six blocks of 100 sweeps, and assessed habituation from amplitude changes between the six sequential blocks. In healthy subjects, the CPT decreased block 1 VEP amplitude and abolished the normal VEP habituation (amplitude decrease to repeated stimulation) in patients with migraine studied between attacks; it left block 1 VEP amplitude and abnormal VEP habituation unchanged. These findings suggest that the interictal cortical dysfunction induced by migraine prevents the cortical changes induced by tonic painful stimulation both during pain and after pain ends. Because such cortical changes presumably reflect plasticity mechanisms in the stimulated cortex, our study suggests altered plasticity of sensory cortices in migraine. Whether this abnormality reflects abnormal functional activity in the subcortical structures subserving tonic pain activation remains conjectural.

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Alpha Rhythm Power and the Effect of Photic Stimulation in Migraine with Brain Mapping

Cited by 6 publications

References 13 publications

Sensory Modulation Disorder (SMD) and Pain: A New Perspective

Sensory Modulation Disorder (SMD) and Pain: A New Perspective

Uniform decrease of alpha-global field power induced by intermittent photic stimulation of healthy subjects

Lack of cold pressor test-induced effect on visual-evoked potentials in migraine

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