Alpha-methyltyrosine inhibits formation of reactive oxygen species and diminishes apoptosis in PC12 cells

Woodman, Ryan; Lockette, Warren

doi:10.1016/j.brainres.2009.07.084

Cited by 7 publications

(6 citation statements)

References 67 publications

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“…Because central, presynaptic alpha-2 adrenergic receptors inhibit catecholamine secretion, we first reasoned that there would be a TBI-induced downregulation of the Adra2c gene, which regulates basal sympathetic norepinephrine release, 17 and ongoing catecholamine secretion necessitates an increase in catecholamine synthesis which is toxic to neurons. 18 We also postulated that similar to what was reported following other types of physiological or psychological stress, there would be a TBI-induced upregulation of the sodium chloride cotransporter gene 1 (Nkcc1) and downregulation of the potassium chloride cotransporter gene (Kcc2). A shift in the balance of intraneuronal chloride concentrations mediated by dysregulation of Nkcc1 and Kcc2 transport following injury has been found to shift hyperpolarizing inhibitory γ-amino butyric acid (GABA A ) neurons to depolarizing excitatory neurons.…”

mentioning

confidence: 68%

“…We also investigated the cellular mechanisms by which αMT-dependent inhibition of catecholamine synthesis may prove salutary following TBI. Because central, presynaptic alpha-2 adrenergic receptors inhibit catecholamine secretion, we first reasoned that there would be a TBI-induced downregulation of the Adra2c gene, which regulates basal sympathetic norepinephrine release, 17 and ongoing catecholamine secretion necessitates an increase in catecholamine synthesis which is toxic to neurons 18 . We also postulated that similar to what was reported following other types of physiological or psychological stress, there would be a TBI-induced upregulation of the sodium chloride cotransporter gene 1 (Nkcc1) and downregulation of the potassium chloride cotransporter gene (Kcc2).…”

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confidence: 99%

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Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury

Woodman

Miller

Student

et al. 2023

J Trauma Acute Care Surg

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confidence: 68%

mentioning

confidence: 99%

Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury

Woodman

Miller

Student

et al. 2023

J Trauma Acute Care Surg

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“…Elevated levels of circulating corticosteriods found to mediate the critical role of IL-1β in chronic stress-induced depression and suppressed neurogenesis in mice [10]. The hypercortisolism and excessive inflammatory responses have been also reported to contribute to neuronal apoptosis and death [11,12].…”

Section: Introductionmentioning

confidence: 99%

Possible Modulating Effects of Celecoxib (COX II Inhibitor) on Antide-pressant Action of Duloxetine (SNRI) in Stressed Mice

Khanam¹

2012

TOPROCJ

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Rationale: In recent years, a potential link between inflammation and depression has been shown and the role of proinflammatory cytokines in the pathophysiology of major depressive disorders has been observed. Celecoxib (selective COX-II inhibitor) has been reported to inhibit the production of PGE-II and proinflammatory cytokines and also increase tryptophan levels and serotonin availability in depressed patients. On the other hand, duloxetine (potent SNRI) has been shown to be efficacious in inflammatory and acute pain models in rodents and synergistic interaction with NSAIDs. However, the interactions of duloxetine with celecoxib are currently unknown. Objective: We evaluated the antidepressant effect of celecoxib (15, 30 mg/kg/day for 15 days, ip) alone and in combination with duloxetine (5, 10 mg/kg/day for 15 days, ip) and also the biochemical parameters in stressed mice. Results: Pretreatment of celecoxib (15, 30 mg/kg) for 15 days to forced swim-induced stressed mice produced significant antidepressant effect which has been evidenced by decreased in immobility time in tail suspension test (TST). Celecoxib (30 mg/kg) also showed significant increase in locomotor activity and protective effect on biochemical parameters of oxidative stress by reversing stress-induced increase in TBARS and reduction in GSH levels. Pretreatment with combination of celecoxib with duloxetine (5, 10 mg/kg) showed significant antidepressant and neuroprotective effects against stress induced depression and oxidative damage in mice at both dose levels. Conclusions: This study demonstrated dose-dependent antidepressant action of celecoxib in stressed mice. The combination of celecoxib with duloxetine further enhanced its antidepressant effect on TST in stressed mice. The treatment reversed forced swim-induced elevation in TBARS levels and depleted glutathione activity, suggesting their antioxidant and protective role in brain.

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“…Oxidative stress is probably one of the mechanisms involved in neuronal damage induced by I/R. The brain contains many antioxidant molecules that prevent and/or inhibit harmful free radical reactions (Woodman et al, 2009). Kidney I/R injury often cause damage to remote organs.…”

Section: Introductionmentioning

confidence: 99%

Renal Ischemia Reperfusion Causes Brain Hippocampus Oxidative Damage and Inhibition Effect

Fang¹,

Liang²,

Shi-meng³

2016

Afr J Tradit Complement Altern Med

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Background: The acute kidney injury (AKI) may do damage to remote organs. Objective of the study is to investigate effect of seaweed extract (SE) on brain oxidative damage in kidney ischemia/reperfusion rats. Material and Methods: Animals were randomly divided into five groups. SE pre-fed to rats. Results: Kidney I/R may cause oxidative injury in kidneys and brains tissue in rats. SE pre-treatment can decrease lipid peroxidation levels and increase antioxidant enzymes activities in kidney and brain hippocampus of kidney I/R rats. Conclusion: Our results indicate that SE is useful for brain nerve function keeping in kidney I/R rats.

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Alpha-methyltyrosine inhibits formation of reactive oxygen species and diminishes apoptosis in PC12 cells

Cited by 7 publications

References 67 publications

Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury

Alpha-methyltyrosine reduces the acute cardiovascular and behavioral sequelae in a murine model of traumatic brain injury

Possible Modulating Effects of Celecoxib (COX II Inhibitor) on Antide-pressant Action of Duloxetine (SNRI) in Stressed Mice

Renal Ischemia Reperfusion Causes Brain Hippocampus Oxidative Damage and Inhibition Effect

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