Alpha methyldopa induced hepatotoxicity in pregnancy

Ramalingappa, Padmasri; Aradhya, Hema V.; Hanumantharaya, Nagabushan; Bolarigowda, Priyadarshini

doi:10.5455/2320-1770.ijrcog20140938

Cited by 1 publication

(1 citation statement)

References 8 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Methyldopa considered as the drug of choice in the treatment of non-complicated pregnancy-induced hypertension. The centrally acting sympatholytic action of methyldopa is responsible for its therapeutic effect in the treatment of hypertension during pregnancy which reduces the sympathetic drive to the heart and peripheral circulation, resulting in lowering cardiac output and decrease peripheral vascular resistance 29 . However, methyldopa may cause hepatic necrosis through immunological reaction and there is some evidence support the immunological mechanism such as the absence of a dose relationship and the absence of toxicity in animals, also clinical study indicated that some patient receiving methyldopa and suffering from hepatitis associated with rash or fever, further suggesting a hypersensitivity reaction 30 .…”

Section: Methyldopamentioning

confidence: 99%

Drugs-Inducing Hepatotoxicity

Alshehri

Amjad

Mudawi

2020

Asian Journal of Pharmaceutical Research and Health Care

View full text Add to dashboard Cite

The liver is the largest solid organ, the largest gland, and one of the most vital organs that functions as a center for the metabolism of nutrients and excretion of waste metabolites. Hepatotoxicity is becoming a leading cause of death worldwide and its prevalence is increasing exponentially, there are several causes behind hepatotoxicity such as administration of acetaminophen that induced hepatotoxicity through the excessive formation of the toxic metabolite N-acetyl-para-benzoquinone imine (NAPQI). Drug-induced liver injury may account for approximately 10% of all cases of acute hepatitis, 5% of all hospital admissions, and 50% of all acute liver failures. Remarkably, more than 75% of cases of idiosyncratic drug reactions result in liver transplantation or death. This review will help researchers to understand the hepatotoxicity mechanism of common drugs that have a hepatotoxic effect.

show abstract

Section: Methyldopamentioning

confidence: 99%