Alpha Mannosidase Inhibitory Effect of Some Iranian Plant Extracts

Gholamhoseinian, Ahmad; Fallah, Hossein; Sharififar, Fariba; Mirtajaddini, M.

doi:10.3923/ijp.2008.460.465

Cited by 39 publications

(44 citation statements)

References 19 publications

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“…Significant decrease in fasting glucose levels in the overweight treatment group of osteoarthritis patients [222]. Lack of α-glucosidase inhibitory effects [223]. Selective inhibition of aldose reductase [224] and reduction of advanced glycation end products and H 2 O 2 induced oxidative stress in human adipocytes [225] Polyacetylenes [228].…”

mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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“…While in vitro the IC 50 value for cytoplasmic α-mannosidase was low (8.7 µM), in vivo inhibition was much weaker, requiring 1 mM calystegine B 3 , which might be due to inefficient incorporation of this compound according to the researchers 96 . Inhibitory effects of plant extracts were also found 97 . Their mode of action may be interesting for further investigations, in order to identify single, chemically defined inhibitors of α-mannosidase.…”

Section: High Mannose Speciesmentioning

confidence: 92%

Tailoring recombinant protein quality by rational media design

Brühlmann

Jordan

Hemberger³

et al. 2015

Biotechnology Progress

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Clinical efficacy and safety of recombinant proteins are closely associated with their structural characteristics. The major quality attributes comprise glycosylation, charge variants (oxidation, deamidation, and C‐ & N‐terminal modifications), aggregates, low‐molecular‐weight species (LMW), and misincorporation of amino acids in the protein backbone. Cell culture media design has a great potential to modulate these quality attributes due to the vital role of medium in mammalian cell culture. The purpose of this review is to provide an overview of the way both classical cell culture medium components and novel supplements affect the quality attributes of recombinant therapeutic proteins expressed in mammalian hosts, allowing rational and high‐throughput optimization of mammalian cell culture media. A selection of specific and/or potent inhibitors and activators of oligosaccharide processing as well as components affecting multiple quality attributes are presented. Extensive research efforts in this field show the feasibility of quality engineering through media design, allowing to significantly modulate the protein function. © 2015 American Institute of Chemical Engineers Biotechnol. Prog., 31:615–629, 2015

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“…Flavonoids as one of the most diverse and widespread groups of natural compounds are probably the most important natural phenolics [17,26,27]. These compounds possess a broad spectrum of chemical and biological activities including radical scavenging properties and enzyme inhibition [2,[28][29][30]. Therefore, the content of this group of phenolics was determined in the extracts.…”

Section: Total Phenolic Contentmentioning

confidence: 99%

“…It is characterized by hyperglycemia and accompanied by various chronic vascular complications [1][2][3]. About 171 million people worldwide have diabetes, which is likely to be more than double by 2030 and around 3.2 million deaths every year are attributable to complication of diabetes, six deaths every minute [4,5].…”

Section: Introductionmentioning

confidence: 99%

Twenty Traditional Algerian Plants Used in Diabetes Therapy as Strong Inhibitors of α-Amylase Activity

Khacheba

Djeridane

Yousfi

2014

International Journal of Carbohydrate Chemistry

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In the present work, we have studied the inhibitory effects of aqueous and alcoholic extracts of six Algerian medicinal plants known by their therapeutic virtues against diabetes. The total phenolic compounds content, assayed using Folin-Ciocalteu's reagent, of the samples ranged from 0.183 mg/g to 43.088 mg/g and from 1.197 mg/g to 7.445 mg/g, expressed as gallic acid equivalent (GAE), for the, respectively, whereas the total flavonoids concentrations, detected using 2% of the aluminium chloride, ranged from 0.41 mg/g to 11.613 mg/g and from 0.0097 mg/g to 1.591 mg/g, expressed as rutin equivalents (RE), for the aqueous and methanolic extracts, respectively. The major plants were found to inhibit enzymatic activities of Aspergillus oryzae-amylase in a concentration dependent manner. The values of the inhibition constants ( ) have been determined according to the Dixon and Lineweaver-Burk methods. The results showed that the values were less than 55 ppm for the all extracts. A strong inhibition was found in the phenolic extract of Salvia officinalis with a of 8 ppm.

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Alpha Mannosidase Inhibitory Effect of Some Iranian Plant Extracts

Cited by 39 publications

References 19 publications

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Tailoring recombinant protein quality by rational media design

Twenty Traditional Algerian Plants Used in Diabetes Therapy as Strong Inhibitors of α-Amylase Activity

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