Alpha-Glucosidase Inhibitory and Antioxidant Activity of Solvent Extracts and Fractions of &lt;i&gt;Typha domingensis&lt;/i&gt; (Typhaceae) Fruit

Chai, Tsun-Thai; Chiam, Mei Jee; Lau, Chi Hou; Ismail, Nor Ismaliza Mohd; Ong, Hwai Chyuan; Manan, Fazilah Abd; Wong, Fai-Chu

doi:10.4314/tjpr.v14i11.5

Cited by 9 publications

(7 citation statements)

References 27 publications

(28 reference statements)

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“…However, there was a significant and moderate correlation between proanthocyanidin contents and log(1/IC 50 ) values ( R = 0.6) without the extreme values. Some studies have demonstrated a positive correlation between α ‐glucosidase‐inhibitory activities and proanthocyanidin contents, whereas others have reported no positive relationship . In our study, α ‐glucosidase‐inhibitory activities and proanthocyanidin contents might be related.…”

Section: Resultscontrasting

confidence: 43%

Characteristics of proanthocyanidins in leaves of Chamaecyparis obtusa var. formosana as strong α‐glucosidase inhibitors

Hsu

Lin

et al. 2018

J Sci Food Agric

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Section: Resultscontrasting

confidence: 43%

Characteristics of proanthocyanidins in leaves of Chamaecyparis obtusa var. formosana as strong α‐glucosidase inhibitors

Hsu

Lin

et al. 2018

J Sci Food Agric

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“…While in CFTD, total phenolic contents were determined 24.3 mg GAE/g DE, and flavonoid contents were 84.71 mg QE/g DE extract ( Figure 1 ). The literature review of fruits of T. domingensis revealed that these are very rich in polyphenols (401.46 ± 5.77 mg GAE/g) [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

Dilshad

Khan

Saeed

et al. 2022

BioMed Research International

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Human diseases are becoming more prevalent, necessitating the development of modalities to overcome the challenges of treating various disorders. In the current research, we analyzed the biomedicinal role of Typha domingensis which is an important medicinal plant. The species is traditionally used in the treatment of neurological disorders and skin malignancies. The chloroform (CFTD) and n-butanol fractions of T. domingensis (BFTD) were subjected to chemical profiling through the determination of total polyphenolic contents and GC-MS analysis. The oral toxicity test was applied to investigate the toxicity of the extracts. Antioxidant capacity was analyzed by four in vitro methods: DPPH, ABTS, FRAP, and CUPRAC. The pharmacological potential was evaluated through clinically significant enzyme inhibition assays, thrombolytic, and antimicrobial activities. In silico molecular docking approach was applied to confirm the role of T. domingensis against the enzymes. The polyphenolic quantification revealed that the BFTD was comparatively rich in total phenolic and flavonoid contents (97.14 milligrams gallic acid equivalent (mg GAE/g) and 362.5 milligrams quercetin equivalent per gram of dry extract (mg QE/g DE), respectively), as compared to the CFTD. The GC-MS analysis of the CFTD and BFTD resulted in the tentative identification of 67 and 29 compounds, respectively, with the major components of fatty acids and essential oil. The oral toxicity test revealed the safety and biocompatibility of CFTD and BFTD. Both the fractions showed promising antioxidant activity. Tyrosinase was found as the major enzyme inhibited by BFTD (78.67%) and CFTD (68.09%), whereas the standard kojic acid showed 85.58% inhibition. The inhibition results of acetylcholinesterase and butyrylcholinesterase by BFTD (71.65 and 60.79%, respectively) are higher than CFTD. Both the fractions were found active against various strains of bacteria. Furthermore, the molecular docking studies of the compounds showed a good docking score against all the docked enzymes among which deoxycaesaldekarin C was found with the highest binding affinities in comparison to the standard. The current study suggests that T. domingensis is nontoxic and can be a potential source of phytoconstituents with promising pharmacological potential.

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“…In a few studies, it was suggested that flavanoids of Typha genus play a major role as an antioxidant [33,40,62]. Studies have also shown the relationship between inflammation and antioxidants.…”

Section: Antioxidant Activitymentioning

confidence: 99%

“…T. angustifolia is also shown to have an antioxidant action due to presence of these flavanoids [33]. The female flower and fruit extracts of T. domingensis exhibited antioxidant effects when administered internally [62]. A topical preparation of T. latifolia is used to reduce skin aging due to its antioxidant potential [40].…”

Section: Antioxidant Activitymentioning

confidence: 99%

An Invasive Yet Potentially Diverse and Unexplored Genus: Typha L.

Makwana

Kethwas

Sapoliya

et al. 2021

JPRI

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Aim: Typha genus belongs to the family Typhaceae and is comprising of about 13 known species distributed in the subtropical and tropical regions of North America, South America, Asia, Africa, Australia and Europe. Several species are considered as invasive weeds that colonize wetlands and marshes because they are highly productive by clonal growth, forming very large, persistent and often monospecific stands. This review offers detailed information on the aquatic species of the cosmopolitan genus Typha L. with specific focus on their distribution, identification, importance in bioremediation, usability and traditional uses along with chemical and biological diversity. Methodology: An extensive browsing in three electronic databases (Unbound Medline, PubMed and ScienceDirect) and internet search engines (Scifinder and Google Scholar) enabled us to connote the studies on Typha genus available till date. Results: Literature survey corroborated that some species of Typha are valuable as sources of traditional medicine in human health, while some are still widely used for non-pharmacological purposes. Numerous phytochemical investigations of plants of this genus confirmed the presence of alkaloids, glycosides, tannins, steroids, phenols, saponins, flavanoids, carbohydrates, proteins, oils and fats. Besides, various studies cited in this review article have demonstrated that the extracts or active substances that have been isolated from the species of Typha genus have multiple pharmacological activities. Conclusion: The review draws the attention of scientists towards the utility and important issues associated with the probable approaches that should be investigated to encourage people to take maximal benefit of the potentially useful species of Typha genus.

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Alpha-Glucosidase Inhibitory and Antioxidant Activity of Solvent Extracts and Fractions of <i>Typha domingensis</i> (Typhaceae) Fruit

Cited by 9 publications

References 27 publications

Characteristics of proanthocyanidins in leaves of Chamaecyparis obtusa var. formosana as strong α‐glucosidase inhibitors

Characteristics of proanthocyanidins in leaves of Chamaecyparis obtusa var. formosana as strong α‐glucosidase inhibitors

Chemical Composition and Biological Evaluation of Typha domingensis Pers. to Ameliorate Health Pathologies: In Vitro and In Silico Approaches

An Invasive Yet Potentially Diverse and Unexplored Genus: Typha L.

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