Alpha‐fetoprotein‐producing lung carcinoma: Report of three cases

Hiroshima, Kenzo; Iyoda, Akira; Toyozaki, Tetsuya; Haga, Yukiko; Baba, Masayuki; Fujisawa, Takehiko; Ishikura, Hiroshi; Ohwada, Hayato

doi:10.1046/j.1440-1827.2002.01311.x

Cited by 60 publications

(61 citation statements)

References 28 publications

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“…Later reports described hepatoid adenocarcinoma of lung with components of neuroendocrine carcinoma instead of adenocarcinoma. 11,16 Unlike prior reports, the tumors in the current study were either pure hepatoid adenocarcinoma (three cases) or hepatoid adenocarcinoma with components of signet-ring cells (two cases).…”

Section: Discussioncontrasting

confidence: 61%

“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] All 16 patients were men with large lung tumors. The majority of patients presented with advanced stage disease.…”

Section: Discussionmentioning

confidence: 99%

“…[3][4][5][6][7][8][9]11,12,16,17 AFP immunoassays, ordered by clinicians in three of five current cases, showed marked elevation of serum AFP in one patient (4410 ng/ml). A normal AFP level was concordant with the negative immunohistochemical stain for AFP in one case.…”

Section: Discussionmentioning

confidence: 99%

“…There are only 16 case reports of hepatoid adenocarcinoma of lung in the literature (Table 1). [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Anatomic pathologists should be cognizant of this rare tumor to avoid confusion with metastatic hepatocellular carcinoma. We report four male patients and one female patient with hepatoid adenocarcinoma of lung, modify the diagnostic criteria of Ishikura et al 2 and discuss an immunohistochemical panel to distinguish hepatoid adenocarcinoma of lung from hepatocellular carcinoma metastatic to lung.…”

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confidence: 99%

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Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature

et al. 2014

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The current diagnostic criteria for hepatoid adenocarcinoma of lung include typical acinar or papillary adenocarcinoma and a component resembling hepatocellular carcinoma and expressing a-fetoprotein (AFP). Distinguishing hepatoid adenocarcinoma of lung from hepatocellular carcinoma metastatic to lung is difficult in patients with both lung and liver masses and in patients at risk for lung and liver cancer because of smoking and viral hepatitis, respectively. We studied morphologic features of hepatoid adenocarcinoma of lung and established an immunohistochemical panel to facilitate distinction of hepatoid adenocarcinoma of lung from hepatocellular carcinoma metastatic to lung. Five cases of hepatoid adenocarcinoma of lung were stained with hematoxylin and eosin and mucicarmine for histomorphologic evaluation. The 14-marker immunohistochemical profile was established for hepatoid adenocarcinoma of lung and compared with that of hepatocellular carcinoma. Two cases of hepatoid adenocarcinoma of lung had signet-ring cell components. Three cases were pure hepatoid adenocarcinoma without components of acinar or papillary adenocarcinoma, signet-ring cells or neuroendocrine carcinoma. Like hepatocellular carcinoma, hepatoid adenocarcinoma of lung expresses CK8 (5/5), CK18 (5/5), AFP (3/5) and HepPar1 (5/5), shows cytoplasmic staining with TTF-1 (5/5) and does not express CK14 (0/5). Unlike hepatocellular carcinoma, it expresses CK5/6 (1/5), CK7 (3/5), CK19 (4/5), CK20 (1/5), HEA125 (5/5), MOC31 (5/5), monoclonal CEA (3/5) and napsin A (1/5). An immunohistochemical panel that includes a variety of cytokeratins, monoclonal CEA and EpCAM markers (HEA125 and MOC31) facilitates distinction of hepatoid adenocarcinoma of lung from hepatocellular carcinoma metastatic to lung, especially when correlated with clinical and radiologic findings. We propose modification of the current diagnostic criteria for hepatoid adenocarcinoma of lung. Tumor composition can be either pure hepatoid adenocarcinoma or hepatoid adenocarcinoma with components of typical acinar or papillary adenocarcinoma, signet-ring cells or neuroendocrine carcinoma. AFP expression is not requisite for diagnosis as long as other markers of hepatic differentiation are expressed.

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Section: Discussioncontrasting

confidence: 61%

“…[3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] All 16 patients were men with large lung tumors. The majority of patients presented with advanced stage disease.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature

et al. 2014

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“…4,5 Reports of primary AFP-secreting lung tumours are rare. [6][7][8] Lung metastases from a primary liver tumour or GCT can produce AFP. AFP levels can be elevated in patients with primary lung carcinoma associated with liver metastases; it is believed that regenerating hepatocytes surrounding the metastatic tumour cells are the source of AFP.…”

Section: Discussionmentioning

confidence: 99%

A unique case of an alpha-fetoprotein-producing lung cancer with testicular metastasis

Willder¹,

Thomson²,

Grigor³

et al. 2012

CUAJ

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Alpha-fetoprotein (AFP)-producing primary lung tumours are rare; we present the first case of an AFP-producing lung tumour with metastasis to testes. The patient, a 72-year-old man, presented with a history of flu-like symptoms and abdominal pain. On examination he had a hard, tender left scrotal mass. Imaging showed a 4.4-cm right lower lobe lung mass and the serum-AFP was raised (1189 ng/mL). Left orchidectomy excised a necrotic tumour. Microscopy showed complete hemorrhagic infarction and immunohistochemistry showed a lack of staining for AFP. Serum-AFP rose 3 days post-orchidectomy to 1466 ng/mL. The patient subsequently developed melaena and died. Autopsy revealed a 9 × 5-cm necrotic right lower lobe lung tumour. Immunohistochemistry showed the tumour cells reacted with a pan-cytokeratin antibody and less than 5% expressed AFP. Bilateral adrenal tumour deposits were also identified in addition to those in the bowel and spleen. The expression of AFP solely in the lung lesion and lack of expression in both testes, together with a rise in serum-AFP post-orchidectomy and the bilateral adrenal metastases, is overwhelming evidence for the reversal of the usual situation: a poorly differentiated AFP-secreting metastatic lung adenocarcinoma.

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Novel nanoimaging approach: Antibodious polymeric nanolabel for intracellular alpha‐fetoprotein targeted monitoring

Ünlüer

Ersöz

Say

et al. 2013

Biotechnology Progress

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This study describes preparation and use of novel labeled and antibodious polymeric nanolabels (anti-alpha fetoprotein cross-linked nanolabels) as an immunogenic and semisynthetic nanolabel with potential prognostic and therapeutic roles for hepatoma cancer. Specificity, uptake, and binding efficiencies of the nanolabel have been examined in a human hepatosarcoma cell line HepG2, a human colorectal cell line DLD-1, and a mouse myoblast cell line C2. Labeling of the cells has been performed by treating live and fixed cells with varying concentrations of the nanolabels and then, the cells have been examined under a fluorescence microscope. In addition, all cell lines have also been labeled using FITC-conjugated nanotrastuzumab to compare the results obtained with those of the binding of the FITC-nanoanti-alpha fetoprotein nanolabels. Results show that FITC-conjugated anti-alpha fetoprotein cross-linked nanolabels have been taken up by both live and fixed cells and have efficiently and specifically labeled HepG2 cells at a quite low concentration. Taken all together, the results indicate that the novel targeted nanoimaging tools and technique demonstrated their ability to detect the distribution of the nanolabels as probes in hepatoma cells.

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Alpha‐fetoprotein‐producing lung carcinoma: Report of three cases

Cited by 60 publications

References 28 publications

Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature

Hepatoid adenocarcinoma of the lung: report of five cases and review of the literature

A unique case of an alpha-fetoprotein-producing lung cancer with testicular metastasis

Novel nanoimaging approach: Antibodious polymeric nanolabel for intracellular alpha‐fetoprotein targeted monitoring

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