Alpha cell function interacts with diet to modulate prediabetes and Type 2 diabetes

Roncero-Ramos, Irene; Jiménez-Lucena, Rosa; Alcalá‐Díaz, Juan F.; Vals-Delgado, Cristina; Arenas-Larriva, Antonio P.; Rangel‐Zúñiga, Oriol A.; León-Acuña, Ana; Malagón, Marı́a M.; Delgado-Lista, Javier; Pérez‐Martínez, Pablo; Ordovás, José M.; Camargo, Antonio; López‐Miranda, José

doi:10.1016/j.jnutbio.2018.08.012

Cited by 12 publications

(14 citation statements)

References 49 publications

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“…After dietary intervention, 107 participants had developed T2DM (Incident-T2DM) [ 32 ], while 108 participants who did not develop T2DM were considered as non-T2DM control individuals [ 10 ]. The expression of some of the previously mentioned spliceosome components and splicing factors was differentially altered in the PBMCs of patients who developed T2DM after a median follow-up of 60 months compared to non-T2DM subjects.…”

Section: Resultsmentioning

confidence: 99%

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

et al. 2020

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Type-2 diabetes mellitus (T2DM) has become a major health problem worldwide. T2DM risk can be reduced with healthy dietary interventions, but the precise molecular underpinnings behind this association are still incompletely understood. We recently discovered that the expression profile of the splicing machinery is associated with the risk of T2DM development. Thus, the aim of this work was to evaluate the influence of 3-year dietary intervention in the expression pattern of the splicing machinery components in peripheral blood mononuclear cells (PBMCs) from patients within the CORDIOPREV study. Expression of splicing machinery components was determined in PBMCs, at baseline and after 3 years of follow-up, from all patients who developed T2DM (Incident-T2DM, n = 107) and 108 randomly selected non-T2DM subjects, who were randomly enrolled in two healthy dietary patterns (Mediterranean or low-fat diets). Dietary intervention modulated the expression of key splicing machinery components (i.e., up-regulation of SPFQ/RMB45/RNU6, etc., down-regulation of RNU2/SRSF6) after three years, independently of the type of healthy diet. Some of these changes (SPFQ/RMB45/SRSF6) were associated with key clinical features and were differentially induced in Incident-T2DM patients and non-T2DM subjects. This study reveals that splicing machinery can be modulated by long-term dietary intervention, and could become a valuable tool to screen the progression of T2DM.

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Section: Resultsmentioning

confidence: 99%

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

et al. 2020

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“…11 OGTT, determination of insulin resistance, and secretion by b cell-related indexes OGTT and the determination of insulin resistance and secretion by b cell-related indexes were previously reported. 11,36 In summary, patients underwent a standard Matsuda test at baseline and year-toyear during the follow-up period. After an overnight fast, blood was sampled from a vein before the oral glucose intake (0 min) and again after a 75 g flavored glucose load (75 g dextrose monohydrate in 250 mL water, NUTER-TEC glucosa 50).…”

Section: Biochemical Measurements Of Metabolic Parametersmentioning

confidence: 99%

A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study

Rangel‐Zúñiga

Vals-Delgado

Alcalá‐Díaz

et al. 2021

Molecular Therapy - Nucleic Acids

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MicroRNAs (miRNAs) regulate the expression of genes associated with the development of diseases, including type 2 diabetes mellitus (T2DM). However, the use of miRNAs to predict T2DM remission has been poorly studied. Therefore, we aimed to investigate whether circulating miRNAs could be used to predict the probability of T2DM remission in patients with coronary heart disease. We included the newly diagnosed T2DM (n = 190) of the 1,002 patients from the CORDIOPREV study. Seventy-three patients reverted from T2DM after 5 years of dietary intervention with a low-fat or Mediterranean diet. Plasma levels of 56 miRNAs were measured by OpenArray. Generalized linear model, receiver operating characteristic (ROC), Cox regression, and pathway analyses were performed. ROC analysis based on clinical variables showed an area under the curve (AUC) of 0.66. After a linear regression analysis, seven miRNAs were identified as the most important variables in the group's differentiation. The addition of these miRNAs to clinical variables showed an AUC of 0.79. Cox regression analysis using a T2DM remission score including miRNAs showed that high-score patients have a higher probability of T2DM remission (hazard ratio [HR] low versus high , 4.44). Finally, 26 genes involved in 10 pathways were related to the miRNAs. We have identified miRNAs (hsa-let-7b, hsa-miR-101, hsa-miR-130b-3p, hsa-miR-27a, hsa-miR-30a-5p, hsa-miR-375, and hsa-miR-486) that contribute to the prediction of T2DM remission in patients with coronary heart disease.

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“…[ 42 ] The following indices were calculated at baseline and during every year of follow‐up: hepatic insulin resistance index (HIRI); muscular insulin sensitivity index (MISI); insulin sensitivity index (ISI); insulinogenic index (IGI), and disposition index (DI), as described in previously published. [ 43 ]…”

Section: Methodsmentioning

confidence: 99%

Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study

Gutiérrez-Mariscal

Cardelo

Cruz

et al. 2020

Molecular Nutrition Food Res

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ScopeIt is hypothesized that decreased advanced glycation end products (AGEs) levels could affect type 2 diabetes mellitus (T2DM) remission in newly diagnosed patients through the consumption of two healthy diets.Methods and ResultsPatients from CORDIOPREV study, all with previous cardiovascular events, with T2DM at the beginning of the study are included. Patients are randomized to a Mediterranean or a low‐fat diet for five years. No different diabetes remission rates are found among diets. Serum methylglioxal (MG) and carboximethyllysine (CML), levels dietary AGE, as well as gene expression of AGER1 and RAGE are measured. Serum MG decreases only after the consumption of the Mediterranean diet. Moreover, a COX regression analysis shows that each SD decrease in the MG, occurring after the Mediterranean diet, increases the probability of T2DM remission with HR:2.56(1.02–6.25) and p = 0.046 and each SD increase in disposition index at baseline increases the probability of remission with HR:1.94(1.32–2.87) and p = 0.001.ConclusionsIt is demonstrated that the reduction of serum AGEs levels and the modulation of its metabolism, occurring after the consumption of a Mediterranean diet, might be involved in the molecular mechanism underlying the T2DM remission of newly diagnosed patients with coronary heart disease.

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Alpha cell function interacts with diet to modulate prediabetes and Type 2 diabetes

Cited by 12 publications

References 49 publications

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

Dietary Intervention Modulates the Expression of Splicing Machinery in Cardiovascular Patients at High Risk of Type 2 Diabetes Development: From the CORDIOPREV Study

A set of miRNAs predicts T2DM remission in patients with coronary heart disease: from the CORDIOPREV study

Reduction in Circulating Advanced Glycation End Products by Mediterranean Diet Is Associated with Increased Likelihood of Type 2 Diabetes Remission in Patients with Coronary Heart Disease: From the Cordioprev Study

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