Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenaline-induced vascular contraction in Wistar rats

Connolly, Kylie; Jackson, Douglas; Pullen, Candice; Fenning, Andrew

doi:10.1016/s2095-4964(15)60167-4

Cited by 6 publications

(2 citation statements)

References 37 publications

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“…27,28 In the sympathetic nervous system, noradrenaline stores in the TH + postganglionic neurons and their nerve fibers serve as the main neurotransmitter released from the sympathetic nerve endings for the control of vasoconstriction. 29,30 Since TH + sympathetic fibers mainly distribute around the arrector pili muscles and blood vessels, it is reasonable to consider that they are associated Acupuncture in Medicine, 40 (6) with piloerection and vasomotor regulation and may also be stimulated by acupuncture, which may regulate the activity of vasoconstriction through the release of noradrenaline. 31 In addition, VAChT was used to observe the parasympathetic innervation at these points.…”

Section: Potential Roles Of Sensory and Autonomic Innervationmentioning

confidence: 99%

Sensory and autonomic innervation of the local tissues at traditional acupuncture point locations GB14, ST2 and ST6

Wang

Cui

et al. 2022

Acupunct Med

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Objective: To visualize and compare the sensory and autonomic innervation of the local tissues at the sites of different traditional acupuncture points in the rat forehead and face by histochemical examination. Methods: GB14 ( Yangbai), ST2 ( Sibai) and ST6 ( Jiache) were selected as the representative traditional acupuncture points in this study, and the local tissues at these sites were dissected in rats after perfusion followed by double or triple fluorescent histochemical staining. Here, calcitonin gene-related peptide (CGRP), tyrosine hydroxylase (TH) and vesicular acetylcholine transporter (VAChT) were used to label the sensory, sympathetic and parasympathetic nerve fibers, respectively. Results: The CGRP+ sensory, TH+ sympathetic and VAChT+ parasympathetic nerve fibers were simultaneously demonstrated in the local tissues at GB14, ST2 and ST6. Although the three kinds of nerve fibers ran in parallel or intermingled with each other, by the analysis from the view of three-dimensional reconstruction, it was clear that each of them distributed in an independent pattern to their corresponding target tissues including the blood vessels, hair follicles, arrector pili and subcutaneous muscles, as well as sebaceous glands. Conclusion: Our study demonstrated the sensory and autonomic innervation of the local tissues at GB14, ST2 and ST6, providing neurochemical evidence indicating that the CGRP+ sensory, TH+ sympathetic and VAChT+ parasympathetic nerve fibers form a neural network at these point locations that may respond to acupuncture stimulation.

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Section: Potential Roles Of Sensory and Autonomic Innervationmentioning

confidence: 99%

Sensory and autonomic innervation of the local tissues at traditional acupuncture point locations GB14, ST2 and ST6

Wang

Cui

et al. 2022

Acupunct Med

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“…Noradrenaline (NA)-induced isolated thoracic aorta ring was used to evaluate the in vitro antihypotensive effect of synthetic hybrids 18 . As shown in Table 1, the vasodilation potency of target compounds 6a-r at concentrations of 10 and 100µM was preliminarilyobtained in an organ bath system.…”

Section: Pharmacological Evaluation 221 In Vitro Antihypotensive Activitiesmentioning

confidence: 99%

Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates

Xie

et al. 2019

Bioorganic & Medicinal Chemistry

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7,8-Dihydroxy-3-methyl-isochromanone-4 (XJP), is a polyphenolic natural product with moderate antihypertensive activity. To obtain new agents with stronger potency and safer profile, we employed XJP and naftopidil as the lead compounds to design and synthesize a novel class of hybrids as antihypertensive candidates, In the present study, a series of hybrids (6a-r) of XJP bearing arylpiperazine moiety, which is identified as the pharmacophore of naftopidil, were designed and synthesized as novel α1-adrenergic receptor antagonists. The biological evaluation showed that target compounds 6c, 6e, 6f, 6g, 6h, 6m and 6q possessed potent in vitro vasodilation potency and α1-adrenergic receptor antagonistic activity. Furthermore, the most potent compound 6e significantly reduced the systolic and diastolic blood pressure in spontaneously hypertensive rats (SHRs),which was comparable to that of naftopidil, and it had no observable effects on the basal heart rate, suggesting that 6e deserves to be further investigated as a potential clinical candidate for the treatment of hypertension.

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Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates

et al. 2022

Bioorganic & Medicinal Chemistry

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Alpha-adrenoceptor antagonism by Crassostrea gigas oyster extract inhibits noradrenaline-induced vascular contraction in Wistar rats

Cited by 6 publications

References 37 publications

Sensory and autonomic innervation of the local tissues at traditional acupuncture point locations GB14, ST2 and ST6

Sensory and autonomic innervation of the local tissues at traditional acupuncture point locations GB14, ST2 and ST6

Design, synthesis and biological evaluation of isochroman-4-one hybrids bearing piperazine moiety as antihypertensive agent candidates

Design, synthesis and biological evaluation of hydrogen sulfide-releasing isochroman-4-one derivatives as new antihypertensive agent candidates

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