“…In the previous work by our group, a series of novel H 2 Sreleasing isochroman derivatives was designed and synthesized by combining H 2 S donors with a natural product, (±) 7,8-dihydroxy-3-methyl-isochroman-4-one analogs (XJP), with antihypertensive activity, which exhibited synergistic antihypertensive activity. 25 In this work, we continued our efforts to confirm the rationality of the synergistic pharmacological strategy of "natural product-active gas donor" heterogeneous molecules. Using this strategy, we isolated and identified the excellent antioxidant activities of the lead compounds L13 and L14, which were further used to design and synthesize a series of novel β-elemene hybrids.…”