2020
DOI: 10.31533/pubvet.v14n5a573.1-8
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Alopecia X em cães: revisão

Abstract: Alopecia in dogs is a frequent finding at veterinary dermatological consultations, may be caused by various skin diseases and even systemic. Alopecia X is a dermatopathy that occurs most often in Nordic breeds, especially in German Spitz dogs, about which there is not much scientific knowledge today. Its pathogenesis has not been well understood and is currently believed to be caused by an inherited component associated with changes in sensitivity to hair follicle hormone receptors. The most used treatment is … Show more

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Cited by 3 publications
(12 citation statements)
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“…In cases where there is a clinical suspicion of the disease, a skin biopsy is recommended, which may contribute to the diagnostic screening. Despite this, histopathological examination does not allow to differentiate AX from other non-inflammatory alopecias (Frank, 2017;Gondim, 2020), being necessary to exclude other causal factors that lead to alopecia.…”
Section: Discussionmentioning
confidence: 99%
“…In cases where there is a clinical suspicion of the disease, a skin biopsy is recommended, which may contribute to the diagnostic screening. Despite this, histopathological examination does not allow to differentiate AX from other non-inflammatory alopecias (Frank, 2017;Gondim, 2020), being necessary to exclude other causal factors that lead to alopecia.…”
Section: Discussionmentioning
confidence: 99%
“…Em estudos de sequenciamento genético, cães da raça spitz alemão com alopecia X foram submetidos à biópsia de pele, sendo encontrados 10 genes alterados, responsáveis pela produção de hormônios sexuais e vitamina D, bem como de participarem do metabolismo da melatonina. Esta pesquisa levantou a hipótese do acometimento endócrino do animal com alopecia X, mesmo que apenas local (BRUNNER et al apud GONDIM;ARAUJO, 2020). Anormalidades nos receptores foliculares da derme também constituem uma teoria recente da possível causa da doença (MEDLEAU; HNILICA apud VENÂNCIO et al, 2016).…”
Section: Etiologiaunclassified
“…Atrofia folicular discreta, hiperqueratose, hiperpigmentação, fases telógena e catágena predominantes no ciclo de crescimento piloso, dilatação do infundíbulo folicular, atrofia epidérmica e de glândulas sebáceas são alguns dos achados histopatológicos da biópsia cutânea. Entretanto, são achados inespecíficos, pois ocorrem em diversos quadros de alopecia não inflamatória, independentemente da etiologia, tornando este exame pouco eficaz para a diferenciação da alopecia X de outras doenças (PATEL; FORSYTHE apud GONDIM; ARAUJO, 2020), com exceção dos "folículos em chama", que ocorrem mais frequentemente na alopecia X e indicam excesso de queratinização tricolemal (GROSS et al;MUNTENER et al apud GONDIM;ARAUJO, 2020).…”
Section: Diagnósticounclassified
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