Alopecia in vitamin D-dependent rickets type II responding to 1<i>α</i>-hydroxycholecalciferol

Kumar, Vishal; Kumar, M. Ravi; Yadav, Manisha

doi:10.1179/146532810x12858955921357

Cited by 4 publications

(6 citation statements)

References 13 publications

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“…6 There is one previous case report of alopecia in VDDR II responding to 1,25(OH)2 vitamin D3. 2 Authors also found a similar improvement in alopecia. There is a report of two patients with presentation of only alopecia in the absence of rachitic changes, which might be explained by differences in sensitivity to 1,25(OH)2D3 of bone formation and hair growth.…”

Section: Discussionmentioning

confidence: 67%

“…Our patient had alopecia with severe deformities, aiding the diagnosis, VDDRII is an extremely rare disorder caused by target organ resistance to 1,25(OH)2 vitamin D, the biologically active form of vitamin D. There are a few isolated case reports from India earlier but the exact prevalence of the disease is not yet known. 2,3 It is diagnosed through the finding of normal or elevated circulating levels of 1,25(OH)2 vitamin D, which differentiate it from vitamin D-dependent rickets type I (VDDR I). The latter is caused by defective1-α hydroxylation of 25(OH) vitamin D in the kidneys, resulting in low serum levels of 1,25(OH) vitamin D3.…”

Section: Discussionmentioning

confidence: 99%

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A rare case of Vitamin D dependent rickets type II: a case report

Badabagni¹,

Bodduluri²,

Raju³

2019

Int J Contemp Pediatr

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Vitamin D-dependent type II rickets (VDDRII) is a rare autosomal recessive disorder caused by mutation in the vitamin D receptor gene, leading to end-organ resistance to 1,25(OH)2 vitamin D3. It presents with refractory rickets and growth retardation presenting in the first year of life. It is frequently associated with alopecia totalis. Due to target organresistance, its response to vitamin D is poor. The recommended treatment is giving supra physiological dose of 1,25(OH)2 vitamin D3 and a high dose of oral or intravenous calcium. The response of alopecia to treatment is generally poor. We present a 3 ½ year-old male child with VDDR II whose alopecia and rickets partially responded to 1,25(OH)2 vitamin D3.

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Section: Discussionmentioning

confidence: 67%

Section: Discussionmentioning

confidence: 99%

A rare case of Vitamin D dependent rickets type II: a case report

Badabagni¹,

Bodduluri²,

Raju³

2019

Int J Contemp Pediatr

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“…41 However, alopecia associated with vitamin D deficiency seems mostly to be a feature of vitamin D deficiency associated with type II rickets. 103 Vitamin C deficiency has also rarely been reported to cause diffuse alopecia, with response to supplementation reported in a single case. 104 However, severe vitamin C deficiency is not associated with IBD specifically.…”

Section: Other Nutritional Deficienciesmentioning

confidence: 97%

Hair Loss in Patients with Inflammatory Bowel Disease

Patel

Farrant

Sanderson

et al. 2013

Inflammatory Bowel Diseases

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“…18,23 The mechanism by which the VDR regulates hair growth is still poorly elucidated. 4,17,20,21,24 However, alopecia was related to the type of mutation in VDR gene. 11,13 Screening is crucial.…”

Section: Alopecia As a Sign Of Hypocalcemia Vitamin D-dependent Ricmentioning

confidence: 99%

“…Treatment of HVDDR2 is essential before reaching 3 years of age to avoid complications. 4,24 It consists of high doses of calcitriol and calcium supplementation. 13,16,18,19 Slight or no improvement of alopecia is usually reported.…”

Section: Alopecia As a Sign Of Hypocalcemia Vitamin D-dependent Ricmentioning

confidence: 99%

Rickets in association with skin diseases and conditions: A review with emphasis on screening and prevention

Litaiem

Chabchoub

Bacha

et al. 2020

Photoderm Photoimm Photomed

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Background Rickets is a common disease worldwide. In the developed world, its prevalence dramatically decreased but still diagnosed in at‐risk populations. The skin plays a critical role in vitamin D synthesis. Therefore, several skin diseases, especially keratinization disorders, could lead to impaired vitamin D metabolism and vitamin D deficient rickets. Objective The article aimed to summarize the current knowledge of skin diseases and conditions associated with rickets. Methods To examine the association between rickets and skin diseases, we performed a systematic review of the literature using PubMed database. The search included studies published from the database inception to August 2019. Results A total number of 75 articles were included. Identified conditions associated with rickets were ichthyosis being a more common skin diseases, alopecia, epidermal and melanocytic nevi, xeroderma pigmentosum, mastocytosis, psoriasis, and atopic dermatitis. Three types of rickets were identified: vitamin D‐dependent rickets, hypocalcemic vitamin D‐dependent rickets type 2, and hypophosphatemic rickets. Cutaneous skeletal hypophosphatemia syndrome is a newly described and under‐recognized condition. It is defined by the association of epidermal or melanocytic nevi, hypophosphatemic rickets, and elevated levels of fibroblast growth factor 23. Rickets in patients with ichthyosis was mainly due to impaired ability of ichthyotic skin to synthesize vitamin D, poor UV penetration of the skin caused by keratinocyte proliferation, and dark phototype. The latter may be considered a risk factor for rickets in patients with ichthyosis. Conclusion Despite its rarity, these associations should be properly recognized by dermatologists. Early diagnosis of rickets is important to prevent growth retardation and skeletal deformities.

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Alopecia in vitamin D-dependent rickets type II responding to 1α-hydroxycholecalciferol

Cited by 4 publications

References 13 publications

A rare case of Vitamin D dependent rickets type II: a case report

A rare case of Vitamin D dependent rickets type II: a case report

Hair Loss in Patients with Inflammatory Bowel Disease

Rickets in association with skin diseases and conditions: A review with emphasis on screening and prevention

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