Alopecia in Rhesus macaques correlates with immunophenotypic alterations in dermal inflammatory infiltrates consistent with hypersensitivity etiology

Kramer, Joshua; Fahey, Michele A.; Santos, Rosemary; Carville, Angela; Wachtman, Lynn M.; Mansfield, Keith G.

doi:10.1111/j.1600-0684.2010.00402.x

Cited by 21 publications

(31 citation statements)

References 28 publications

(38 reference statements)

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“…Overall, there was no significant effect of sex on alopecia. This result is in contrast to many previous studies on alopecia that report a significant sex difference, typically with more females than males showing hair loss . This sex difference has been attributed in part to pregnancy .…”

Section: Discussioncontrasting

confidence: 99%

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Factors influencing alopecia and hair cortisol in rhesus macaques (Macaca mulatta)

Lutz

Coleman

Worlein

et al. 2016

J of Medical Primatology

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Background Alopecia can occur in captive nonhuman primates, but its etiology is poorly understood. The purpose of this study was to assess alopecia and hair cortisol in rhesus monkeys and to identify potential risk factors. Methods Subjects were 117 rhesus monkeys at two National Primate Research Centers. Photographs and hair samples were obtained during routine physicals. Photographs were analyzed using Image J software to calculate hair loss, and hair samples were assayed for cortisol. Results Age, days singly housed, and their interactions contributed to the alopecia model for both facilities. Sex and location changes contributed to the hair cortisol model for Facility 1; sedations contributed for Facility 2. Alopecia and hair cortisol were associated at Facility 1. Conclusions Captive management practices can affect alopecia and hair cortisol. However, there are facility differences in the relationship between alopecia and hair cortisol and in the effect of intrinsic variables and management procedures.

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Section: Discussioncontrasting

confidence: 99%

“…In previous studies, alopecia has been reported to increase with age [4,21,31]; older animals tended to have greater amounts of alopecia and hair thinning than their younger counterparts [19,31]. However, this relationship is not consistent across studies.…”

Section: Age and Single Housing Effectmentioning

confidence: 94%

Factors influencing alopecia and hair cortisol in rhesus macaques (Macaca mulatta)

Lutz

Coleman

Worlein

et al. 2016

J of Medical Primatology

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“…[51][52][53] In rhesus macaques, animals with reduced pathogen burden as a result of indoor housing display skin pathology consistent with chronic hypersensitivity dermatitis and animals with a prior history of outdoor housing or exposure to lung mites had a reduced incidence of dermatitis. 54 A mechanistic explanation for the ''hygiene hypothesis'' is not completely elucidated, although shifts in cytokine profiles, down-regulation of CD25 + T regulatory cells, and antigenic competition have been suggested as contributing factors. 47 The examination of hematologic parameters and cellular immunophenotypes revealed an increased percentage of CD25 + B lymphocytes in standard SPF macaques.…”

Section: Santos Et Almentioning

confidence: 99%

Specific Pathogen-Free Status Alters Immunophenotype in Rhesus Macaques: Implications for the Study of Simian Immunodeficiency Virus

Santos

Lin

Mansfield

et al. 2011

AIDS Research and Human Retroviruses

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The repertoire of viruses to which research primates are exposed, even in the absence of clinical disease, may contribute to experimental confounding. In this study we examined whether standard specific pathogen-free (SPF) rhesus macaques exposed to a wider spectrum of enzootic viruses and expanded SPF macaques derived to exclude a greater number of viral agents would display alterations in immune activation or immune cell populations. Given the impact of immunophenotype on human immunodeficiency virus (HIV) progression and the importance of the simian immunodeficiency virus (SIV) model for the study of HIV pathogenesis, we elected to additionally examine the impact of SPF status on the capacity of peripheral blood mononuclear cells (PBMCs) to support SIV replication. The expanded SPF group displayed significant immune alterations including increased serum interleukin (IL)-15 and a greater in vitro elaboration of GM-CSF, IL1ra, VEGF, IL-10, IL12/23, and MIP-1b. Consistent with reduced viral antigenic exposure in expanded SPF macaques, decreased CD4 + and CD8 + transitional and effector memory (T EM ) cell populations were observed. Expanded SPF PBMC cultures also demonstrated an increased peak (192.61 ng/ml p27) and area under the curve in in vitro SIV production (1968.64 ng/ml p27) when compared to standard SPF macaques (99.32 ng/ml p27; p = 0.03 and 915.17 ng/ml p27; p = 0.03, respectively). In vitro SIV replication did not correlate with CD4 + T EM cell counts but was highly correlated with serum IL-15 in the subset of animals examined. Findings suggest that an altered immunophenotype associated with the maintenance of primates under differing levels of bioexclusion has the potential to impact the outcome of SIV studies and models for which the measurement of immunologic endpoints is critical.

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“…Severe alopecia is less common than mild alopecia. Monkeys with mild hair loss did not show HPA axis elevation, and their hair loss may be related to other factors, such as low‐grade inflammation …”

Section: Introductionmentioning

confidence: 96%

“…Monkeys with mild hair loss did not show HPA axis elevation, and their hair loss may be related to other factors, such as low-grade inflammation. 5 We examined the efficacy of polyunsaturated fatty acids (PUFAs) as a treatment for mild alopecia (<30% hair loss). Treatment with PUFAs has been shown to improve both skin and hair condition.…”

Section: Introductionmentioning

confidence: 99%

Fatty acid supplements improve hair coat condition in rhesus macaques

Hamel

Menard

Novak

2017

J of Medical Primatology

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Alopecia in Rhesus macaques correlates with immunophenotypic alterations in dermal inflammatory infiltrates consistent with hypersensitivity etiology

Abstract: Background-Although alopecia is a commonly recognized problem affecting many captive Rhesus macaque colonies, there is no consensus as to the underlying etiology or appropriate course of management.

Cited by 21 publications

References 28 publications

Factors influencing alopecia and hair cortisol in rhesus macaques (Macaca mulatta)

Factors influencing alopecia and hair cortisol in rhesus macaques (Macaca mulatta)

Specific Pathogen-Free Status Alters Immunophenotype in Rhesus Macaques: Implications for the Study of Simian Immunodeficiency Virus

Fatty acid supplements improve hair coat condition in rhesus macaques

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