Alopecia areata masquerading as frontal fibrosing alopecia

Kwong, Rhonda A.; Kossard, Steven

doi:10.1111/j.1440-0960.2006.00227.x

Cited by 15 publications

(11 citation statements)

References 14 publications

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“…These features have been described in alopecia areata patients (29,30). Scalp biopsies from two patients showed peribulbar lymphocytic inflammation of the hair follicles, associated with reduced follicle density, decreased presence of the anagen phase, increased presence of the catagen/telogen phase, and predominance of vellus hair.…”

Section: Discussionmentioning

confidence: 54%

Novel and recurrent mutations in the AIRE gene of autoimmune polyendocrinopathy syndrome type 1 (APS1) patients

et al. 2009

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Autoimmune polyendocrinopathy syndrome type 1 (APS1) is characterized by the presence of at least two out of three clinical features, which include Addison's disease, hypoparathyroidism, and chronic mucocutaneous candidiasis. This disorder is caused by mutations in the AIRE (autoimmune regulator) gene. While several AIRE mutations have been described in APS1 patients of various ethnic origins, the genetic cause of APS1 in Arab patients requires further investigation. This study describes seven Arab families, in which 18 patients had APS1. In addition to the cardinal features of APS1, some patients exhibited alopecia, diabetes mellitus, nephrocalcinosis and other phenotypes associated with APS1. DNA sequencing of the AIRE gene of patients from this study identified four novel and one recurrent mutation. These mutations likely result in loss of AIRE function in the patients. In addition, it was noted that the non-pathogenic c.834C> G mutation (rs1800520, encoding for p.Ser278Arg) occurs with high incidence in the AIRE gene of Arab individuals. Furthermore, this investigation demonstrates inflammation of the hair follicles in APS1 patients with alopecia universalis. We conclude that Arab APS1 patients carry novel and recurrent mutations in the AIRE gene.

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Section: Discussionmentioning

confidence: 54%

Novel and recurrent mutations in the AIRE gene of autoimmune polyendocrinopathy syndrome type 1 (APS1) patients

et al. 2009

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“…There may be some difficulty in differentiating FFA from alopecia areata. A scalp biopsy is strongly recommended to differentiate among these conditions (31).…”

Section: Differential Diagnosismentioning

confidence: 99%

Lichen planopilaris

Kang

Alzolibani

Otberg

et al. 2008

Dermatologic Therapy

114

115

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Lichen planopilaris is a chronic scarring alopecia characterized by follicular hyperkeratosis, perifollicular erythema, and loss of follicular orifices. The scalp lesions may be single or multiple and commonly involve the vertex and parietal area. The hair follicles at the margin of the alopecic patches reveal perifollicular erythema. Anagen hairs can be pulled out easily in active lesions. Associated cutaneous, nail, and mucous membrane lichen planus may be present. Commonly encountered symptoms and signs are increased hair shedding, itching, scaling, burning, and tenderness. Differentiation from other cicatricial alopecia can be performed through meticulous evaluation of the clinical, histopathologic, and immunohistopathologic findings. Treatment strategies depend on the disease activity and physician expertise. Although there are no definitive curative modalities, some new discoveries and conceptual advances continue to broaden our treatment options of this complex condition.

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“…879 900 and with a congenital nevus, 901 and following vasectomy. 905 Migratory poliosis may be a forme fruste of alopecia areata. 859,903 Reduced sweating has also been documented.…”

Section: Trichotillomania and Traumatic Alopeciamentioning

confidence: 99%

Diseases of cutaneous appendages

Weedon

2010

Weedon's Skin Pathology

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Alopecia areata masquerading as frontal fibrosing alopecia

Cited by 15 publications

References 14 publications

Novel and recurrent mutations in the AIRE gene of autoimmune polyendocrinopathy syndrome type 1 (APS1) patients

Novel and recurrent mutations in the AIRE gene of autoimmune polyendocrinopathy syndrome type 1 (APS1) patients

Lichen planopilaris

Diseases of cutaneous appendages

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