Lichen planopilaris

Kang, Hoon; Alzolibani, Abdullateef A.; Otberg, Nina; Shapiro, Jerry

doi:10.1111/j.1529-8019.2008.00206.x

Cited by 114 publications

(141 citation statements)

References 64 publications

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“…Liken planopilaris (LPP) kıl follikülünün otoreaktif lenfositik hasarı ile karakterli, kronik ve progresif seyirli bir sikatrisyel alopesi tipidir 1 . Nadir görülen bir hastalık olup, tüm alopesilerin %1,25'ini, sikatrisyel alopesilerin ise %25'ini oluşturur 2,3 .…”

Section: Introductionunclassified

“…Nadir görülen bir hastalık olup, tüm alopesilerin %1,25'ini, sikatrisyel alopesilerin ise %25'ini oluşturur 2,3 . Hastalığın klasik LPP, Graham-Little sendromu ve frontal fibrozan alopesi (FFA) olmak üzere 3 klinik formu vardır 1,4 . Klasik LPP, skalpte dağınık şekilde ortaya çıkan, perifolliküler eritem ve/veya mor-kahverengi likenoid papüller ile spinöz folliküler hiperkeratozun eşlik ettiği kısmi saç kayıpları ile karakterizedir 1,2,[4][5][6] .…”

Section: Introductionunclassified

“…Hastalığın klasik LPP, Graham-Little sendromu ve frontal fibrozan alopesi (FFA) olmak üzere 3 klinik formu vardır 1,4 . Klasik LPP, skalpte dağınık şekilde ortaya çıkan, perifolliküler eritem ve/veya mor-kahverengi likenoid papüller ile spinöz folliküler hiperkeratozun eşlik ettiği kısmi saç kayıpları ile karakterizedir 1,2,[4][5][6] . Zamanla lezyonlarda skar, atrofi ve depigmentasyon gelişir 5,6 .…”

Section: Introductionunclassified

“…Zamanla lezyonlarda skar, atrofi ve depigmentasyon gelişir 5,6 . Graham-Little sendromu, LPP'nin çok nadir görülen bir formu olup, skalpte yama tarzında sikatrisyel alopesi, aksiller ve pubik bölgelerdeki kıllarda sikatrisyel olmayan tipte kayıp ile gövde ve ekstremitelerde gruplaşmış folliküler papüller izlenir 1,4 . FFA ilk olarak 1994'te Kossard 7 tarafından tanımlanmıştır.…”

Section: Introductionunclassified

“…Sonraki yıllarda, hastalığın daha iyi anlaşılmasıyla birlikte literatürdeki olguların sayısı giderek artmıştır [8][9][10] . Tipik olarak postmenopozal kadınlarda görülmekle birlikte nadir de olsa premenopozal kadınlarda ve erkeklerde de bildirilmiştir 1,8,9 . Çoğunlukla kaş dökülmesinin de eşlik ettiği, frontotemporal saç çizgisinde geriye çekilme ve yeni oluşan saç çizgisinde perifolliküler eritem ile folliküler hiperkeratoz tipiktir [8][9][10][11] .…”

Section: Introductionunclassified

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Lichen planopilaris: Demographic, clinical and histopathological characteristics and treatment outcomes of 25 cases

Özcan¹,

Seckın²,

Güleç³

et al. 2015

TURKDERM

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Background and Design: Lichen planopilaris (LPP) is a type of cicatricial alopecia characterized by autoreactive lymphocytic destruction of the hair follicle. We aimed to evaluate the demographic, clinical and histopathological features, and treatment outcomes of patients with LPP. Materials and Methods: Medical reports of 25 patients, who have been diagnosed with LPP according to the clinical and histopathological findings between January 2006 and June 2012, were retrospectively reviewed. The transverse and vertical sections of scalp biopsy specimens were re-evaluated by a pathologist, and the findings were noted. Results: Of the 25 patients, 18 were female and 7 were male, the mean age was 49.8±12.4 years. Eighteen patients had been diagnosed with classic LPP and 7 patients with frontal fibrosing alopecia (FFA). The alopecia has begun in postmenopausal period in 5 patients with FFA. Alopecia was associated with pruritus, pain and/or burning in 19 patients. Extra-scalp involvement was observed in 11 patients. The most common clinical findings were follicular hyperkeratosis (92%), perifollicular erythema (48%), perifollicular lichenoid papules, and positive hair-pull test (44%). Dermatoscopic examination was performed in 14 patients, and most commonly, absence of follicular openings (100%), perifollicular scales (92.9%) and perifollicular erythema (50%) were noted. The most common diagnostic histopathological findings were follicular vacuolar and lichenoid degeneration (88%) and vacuolar and lichenoid interface changes (56%). Twenty-three patients who were started on treatment received topical, intramuscular and intralesional corticosteroids, topical minoxidil, oral tetracycline, cyclosporine A, and hydroxychloroquine either alone or in combination. Progression of alopecia was prevented and the symptoms and/or signs were reduced in 12 (75%) of 16 patients whose follow-up data were available. Conclusion: LPP can be diagnosed accurately through a detailed clinical examination, dermatoscopy and histopathological examination. The symptoms and/or signs can be reduced and progression of the disease can be prevented with treatment.

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Section: Introductionunclassified