Alopecia areata in the United States: a ten-year analysis of patient characteristics, comorbidities, and treatment patterns

Gutierrez, Yasmin; Pourali, Sarah P.; Jones, Madison; Rajkumar, Jeffrey; Kohn, Alison H.; Compoginis, Goli; Armstrong, April W.

doi:10.5070/d3271055631

Cited by 6 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Differences may be in part due to different AA severity distributions (not reported for the claims database study) and the difference in study period. Another cross-sectional US population-based analysis from 2006 to 2016 reported AA treatments from outpatient visits using the Centers for Disease Control and Prevention National Ambulatory Medical Care Survey (NAMCS) [ 7 ]. The rates reported in this study for topical corticosteroids (34%) and injectable corticosteroids (25%) were more in line with those in our study.…”

Section: Discussionmentioning

confidence: 99%

“…Dermatologists identified all current and prior treatment options for each of their patients: (1) topical corticosteroids, (2) oral corticosteroids, (3) injected corticosteroids, (4) topical immunotherapy (including diphenylcyclopropenone, dinitrochlorobenzene, squaric acid dibutylester), ( 5) immunomodulator (including azathioprine, cyclosporine A, mycophenolate mofetil, methotrexate), ( 6) topical anthralin, (7) minoxidil, (8) finasteride, (9) dithranol, (10) Retin-a/tretinoin, (11) psoralen and ultraviolet radiation A (PUVA), ( 12) ultraviolet radiation A (UVA), (13) Combination corticosteroids was defined as any combination that includes corticosteroids, including multiple types of corticosteroids (e.g., topical ? oral corticosteroids, oral corticosteroids ?…”

Section: Classification Of Aa Treatments and Treatment Satisfactionmentioning

confidence: 99%

“…Reasons for dissatisfaction were asked of those responding ''dissatisfied'' or worse on the treatment satisfaction question. Multiple response options included (1) lack of efficacy overall, (2) slow onset of action, (3) efficacy is diminishing over time, (4) persistent symptoms (pain, burning sensation, itch, tingling sensation), ( 5) alopecia areata is still impacting the patient's quality of life, (6) side effects, (7) patient dislikes mode of administration/finds it too burdensome, (8) lack of compliance, (9) patient not satisfied, (10) other.…”

Section: Classification Of Aa Treatments and Treatment Satisfactionmentioning

confidence: 99%

“…For instance, a recent international Delphi panel on treatment reached consensus for only a third of treatmentspecific questions [5]. Two recently published USA-based national studies contain limited treatment information, without reporting on treatment switches, treatment by AA severity, or treatment satisfaction [6,7]. The most common AA treatments reported for US data were topical and injectable corticosteroids [7].…”

Section: Introductionmentioning

confidence: 99%

“…Two recently published USA-based national studies contain limited treatment information, without reporting on treatment switches, treatment by AA severity, or treatment satisfaction [ 6 , 7 ]. The most common AA treatments reported for US data were topical and injectable corticosteroids [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Treatment Patterns and Treatment Satisfaction Among Adults with Alopecia Areata in the United States

Fridman¹,

Ray

Gandhi

et al. 2022

Adv Ther

View full text Add to dashboard Cite

Introduction: Alopecia areata (AA), an autoimmune disease, is characterized by non-scarring hair loss involving the scalp, face, and/or body. Prior to 2022, no US Food and Drug Administration (FDA)-approved treatments for AA were available in the USA; existing treatment options had limited efficacy and durability and are often associated with side effects. This study aimed to evaluate the current AA treatment patterns and treatment satisfaction as reported by dermatologists. Methods: Real-world data from a 2019 crosssectional survey of US dermatologists and their adult patients with AA were analyzed. Dermatologists provided comprehensive data on their patients with AA, including AA dermatologistassessed severity, treatments, treatment

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Classification Of Aa Treatments and Treatment Satisfactionmentioning

confidence: 99%

Section: Classification Of Aa Treatments and Treatment Satisfactionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Treatment Patterns and Treatment Satisfaction Among Adults with Alopecia Areata in the United States

Fridman¹,

Ray

Gandhi

et al. 2022

Adv Ther

View full text Add to dashboard Cite

show abstract

New Treatment Options for Alopecia Areata

Griss

2023

hautnah

View full text Add to dashboard Cite

ZusammenfassungDie Alopecia areata ist mit einer Lebenszeitprävalenz von 2 % eine der häufigsten Autoimmunerkrankungen. Sie betrifft Menschen in jedem Alter und geht, obwohl es sich dabei um eine harmlose Erkrankung handelt, oft mit einer hohen Beeinträchtigung der Lebensqualität einher. Rezente Studien zeigten, dass Patienten mit Alopecia areata häufiger an Depressionen und Arbeitslosigkeit leiden. Das zeigt, dass effektive Therapien dringend benötigt werden. In dieser Übersicht werden die primären Erscheinungsformen und Pathogenese der Alopecia areata besprochen. Der Schwerpunkt liegt jedoch in einer Übersicht der derzeit verfügbaren Therapien und ihrer Wirksamkeit. Ein besonderer Schwerpunkt ist hier dem JAK-Inhibitor Baricitinib gewidmet, das als erste Therapie für die fortgeschrittene Alopecia areata zugelassen wurde. Diese neue Therapie zeigt eine bisher unerreichte Wirksamkeit, hat jedoch eine breite Diskussion über die Kosten und auch Risiken möglicher Therapien für die Alopecia areata, als rein kosmetische Erkrankung, ausgelöst.

show abstract

The burden of alopecia areata: A scoping review focusing on quality of life, mental health and work productivity

Muntyanu

Gabrielli

Donovan

et al. 2023

Acad Dermatol Venereol

View full text Add to dashboard Cite

Alopecia areata (AA) is a common inflammatory autoimmune disease of the hair which can have a significant negative impact on quality of life (QoL), mental health and productivity. The aim of this scoping review is to elucidate the burden of AA focusing on these three realms. Inclusion criteria included all original manuscripts with no restriction on study type or statistical method written in English (or having an English abstract). For QoL 40 articles were included, 85 for psychiatric comorbidities, and 9 for work/school absenteeism/presenteeism mostly consisting of cross‐sectional and observational cohort studies. QoL impairment was detected in over 75% of patients and up to one‐third reported extremely severe QoL impairments. Specific QoL dimensions with the greatest impact were embarrassment, social functioning, as well as shopping and/or housework. Cross‐sectional studies assessing the psychological burden of adult patients with AA found that the presence of signs of anxiety and/or depression ranged from 30% to 68% and affected all age groups. Rates of work absenteeism and unemployment were significantly higher in AA patients compared to healthy controls. Up to 62% reported making major life decisions including relationships, education and career based on their AA. Additionally, the extensive camouflage techniques and time lost from work led to a strong financial burden for patients and the numerous physician visits added to the healthcare costs. The overall impact of AA stretches much further than simply being an aesthetic concern and can negatively impact every part of an individual's life. An individualized approach and effective treatments will help reduce the psychosocial consequences and distress and return patients to their normal state of health.

show abstract

Alopecia areata in the United States: a ten-year analysis of patient characteristics, comorbidities, and treatment patterns

Cited by 6 publications

References 0 publications

Treatment Patterns and Treatment Satisfaction Among Adults with Alopecia Areata in the United States

Treatment Patterns and Treatment Satisfaction Among Adults with Alopecia Areata in the United States

New Treatment Options for Alopecia Areata

The burden of alopecia areata: A scoping review focusing on quality of life, mental health and work productivity

Contact Info

Product

Resources

About