Treatment Patterns and Treatment Satisfaction Among Adults with Alopecia Areata in the United States

Fridman, Moshe; Ray, Mark; Gandhi, Kavita; Shy, Morgan E; Mostaghimi, Arash

doi:10.1007/s12325-022-02338-4

Cited by 4 publications

(3 citation statements)

References 16 publications

(23 reference statements)

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“…Use of conventional immunosuppressants increased with disease severity and subsequent lines of therapy. Similar patterns have been observed in the United States [29]. This is consistent with published expert opinions that position conventional immunosuppressants mostly for adult patients with severe AA and generally after corticosteroids or as steroid-sparing agents [18,26,27].…”

Section: Discussionsupporting

confidence: 87%

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A description of alopecia areata in European patients based on real-world survey data: physician-reported characterization of severity and associated treatment utilization

Galván,

Piraccini,

Reygagne

et al. 2023

European Journal of Dermatology

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Background: Alopecia areata (AA), an autoimmune disease affecting the hair of the scalp, face, and/or body, can entail substantial psychological and physical burden for patients. There is currently no international agreement on how to treat AA and the approach may vary across countries. Objectives: This study investigated the management of AA in clinical practice. Materials & Methods: Data from a point-in-time survey conducted in France, Germany, Italy, Spain, and the United Kingdom, between October 2021-June 2022, were analysed for adults with mild, moderate, and severe AA, based on physician assessment. Dermatologists were surveyed about factors used to assess disease severity, physician-reported treatment goals, and treatment patterns for AA, including the use of wigs. Results: In total, 239 dermatologists reported on 2,083 patients. Physicians' severity assessment and treatment goals were predominantly driven by scalp hair loss. Topical and intralesional corticosteroids were the most prescribed treatments for mild and moderate AA. Conventional immunosuppressants, oral Janus kinase inhibitors, and topical immunotherapy use generally increased with AA severity and therapy line. Wig use was greatest for severe AA. The primary reasons for the last treatment change in the moderate and severe groups were worsening of condition, lack of initial efficacy, and loss of response, and for mild group were improvement in condition, lack of initial efficacy, and worsening of condition. Findings were generally similar across countries. Conclusion: This analysis provides insights into the management of AA in five European countries and confirms the need for more effective therapies, especially for patients with severe AA.

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Section: Discussionsupporting

confidence: 87%

“…In a recent study in Japan, topical corticosteroids were the most frequently prescribed treatment for AA [28]. Several studies have described treatment patterns in the United States and reported similar findings [29][30][31]. Despite limited evidence, corticosteroids remain the mainstay of AA pharmacological management [7,26].…”

Section: Discussionmentioning

confidence: 99%

A description of alopecia areata in European patients based on real-world survey data: physician-reported characterization of severity and associated treatment utilization

Galván,

Piraccini,

Reygagne

et al. 2023

European Journal of Dermatology

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“… 5 , 7 , 8 Overall, patients and dermatologists considered their experience with commonly used traditional therapies to be unsatisfactory. 3 , 7 , 9 There have therefore been numerous calls for more effective treatment options. 2 , 10 , 11 With a greater understanding of disease pathogenesis, the development of new treatments for AA have been successful and approved.…”

Section: Introductionmentioning

confidence: 99%

Patient-Reported Burden of Severe Alopecia Areata: First Results from the Multinational Alopecia Areata Unmet Need Survey

Bewley,

Figueras-Nart,

Zhang

et al. 2024

CCID

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Purpose Alopecia areata (AA) is an autoimmune disease characterized by hair loss that has significant psychosocial implications. This study aims to describe the patient-reported burden of severe AA, coping mechanism and information needs using data from the multinational AA Patient Satisfaction and Unmet Need Survey. Patients and Methods Participants with current or previous ≥50% scalp hair loss (n = 747) were recruited from 11 countries and completed a web-based survey that assessed demographics, clinical characteristics, disease burden and psychosocial impact. Data were stratified according to sex, current age, disease duration and current severity of scalp hair loss. Results The mean (SD) age of participants was 43.8 (7.1) years, 55.3% were women, and 63.5% reported AA symptoms within 6 months of diagnosis. Most participants had black or brown hair (88.4%), reported a disease duration of 2 years or more (75.6%) and had current scalp hair loss of ≥50% (87.4%). Severe hair loss also extended to eyebrow (46.9%), eyelash (48.7), beard (61.5%) and body hair (73.2%). Participants commonly reported comorbidities such as anxiety (26.1%), depression (18.1%) and sleep problems (28.1%). The Dermatology Life Quality Index revealed a severe impact on quality of life; 86.2% of participants scored >10. Mental health/mood was significantly affected; 55.8% of participants reported a substantial impact. Long-term effects included decreased self-esteem (32.9%), poor mental health (28.1%) and challenges in day-to-day activities (27.2%). Information needs were centered around treatment expectations, mental health, and available treatment options. More severe symptoms and a greater daily impact were reported by women and those with a longer disease duration. Conclusion The study emphasizes the substantial burden, including impaired quality of life and psychological well-being, of severe AA on the lives of surveyed participants. The findings highlight the importance of comprehensive disease management strategies that address both physical and psychosocial aspects of AA.

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Epidemiology, Treatment Patterns, and Healthcare Resource Utilization Study of Patients With Alopecia Areata in Taiwan’s National Health Insurance Research Database

Tsai,

Huang,

Wei

et al. 2024

Value in Health Regional Issues

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Treatment Patterns and Treatment Satisfaction Among Adults with Alopecia Areata in the United States

Cited by 4 publications

References 16 publications

A description of alopecia areata in European patients based on real-world survey data: physician-reported characterization of severity and associated treatment utilization

A description of alopecia areata in European patients based on real-world survey data: physician-reported characterization of severity and associated treatment utilization

Patient-Reported Burden of Severe Alopecia Areata: First Results from the Multinational Alopecia Areata Unmet Need Survey

Epidemiology, Treatment Patterns, and Healthcare Resource Utilization Study of Patients With Alopecia Areata in Taiwan’s National Health Insurance Research Database

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