Alopecia Areata

Gilhar, Amos; Etzioni, Amos; Paus, Ralf

doi:10.1056/nejmra1103442

Cited by 521 publications

(722 citation statements)

References 88 publications

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“…The lifetime risk of AA is reported to be approximately 2%. 1 The incidence rates of the severe forms of AA such as alopecia totalis (AT) and alopecia universalis (AU) are lower and range 3.5-30% of all cases. 2 AU is usually resistant to therapy; therefore, further investigations into new treatments for the condition are needed.…”

Section: Introductionmentioning

confidence: 99%

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Arakawa

Nomiyama

Katoh

2016

The Journal of Dermatology

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Three hundred and eight nanometer excimer light therapy has recently been reported to be effective against patchy alopecia areata (AA) in several clinical studies. However, these studies only included a few patients with severe forms of AA, and all of them exhibited poor outcomes. We further investigated the use of excimer light as a therapeutic option for cases of alopecia universalis (AU) that are resistant to other treatments. Eleven treatmentresistant AU patients were treated with a 308-nm excimer light at 2-week intervals for more than 16 sessions. Four patients achieved good responses and two patients exhibited poor responses. Three patients had Japanese skin type 1 and all of them achieved good responses. The radiation dose was increased until the patients exhibited marked erythema. The patients with Japanese skin type 3 who achieved good responses exhibited strong pigmentation at the irradiated sites. In conclusion, 308-nm excimer light therapy has significant effects on some AU patients who are resistant to other treatments and may be an alternative therapeutic option for AU. During the treatment of AU, high doses of radiation should be administrated until a strong inflammatory skin reaction is seen.

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Section: Introductionmentioning

confidence: 99%

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Arakawa

Nomiyama

Katoh

2016

The Journal of Dermatology

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“…The hair follicles are reversibly damaged mainly by cytotoxic T lymphocytes and cytokines (in-terferon-γ, interleukin-2, and interleukin-15 receptor β); which eventually results in falling out of the hair from the follicle [4]. Tumor Necrosis Factor-Alpha (TNF Alpha) is a pro-inflammatory cytokine and acts as an acute phase reactant which is produced mainly by activated macrophages and other cells like CD4+ lymphocytes, neutrophils, eosinophils, etc.…”

Section: Introductionmentioning

confidence: 99%

Biologic: A Double Edged Sword - A Case of Etanercept Induced Alopecia Areata in a Patient with Psoriasis Vulgaris

Chowdhry¹,

Priya²,

D’Souza³

et al. 2018

SOJMID

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Psoriasis vulgaris is a chronic inflammatory disorder which can only be controlled with medications but not cured. Various modalities are available for the management of same with varying efficacy and adverse effects. Biologics, though not new, have changed the concept of treatment of psoriasis. With beneficial effects, they also have adverse effects which are being identified more and more with passing time.

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“…Alopecia areata (AA) is a most common cause of hair loss, 1 characterized by patchy, confluent, or diffuse hair loss in normal-appearing skin. Area of hair loss usually involve in the scalp and region of the beard, or even on the whole body.…”

Section: Introductionmentioning

confidence: 99%

“…Together with clinical presentation of hairloss, exclamation-mark hairs, cadaver hairs and nail pitting often render the diagnosis of AA. 1 About 16% of AA patients are reported to associate with other allergic or autoimmune diseases including atopic dermatitis (AD), vitiligo, autoimmune thyroid disease. 2,3 Helpful therapeutic options with immunosuppressive or immune-deviation strategy are suggested to clinician on these days.…”

Section: Introductionmentioning

confidence: 99%

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Successful Treatment of Multiple Alopecia Areata With Contact Immunotherapy: Supportive Usage of Oral Antihistamine and Topical Corticosteroid

Kaga¹,

Ikeda²

2017

Dermatol Open J

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Contact immunotherapy using diphenylcyclopropenone (DPCP) is a commonly used first-line therapeutic technique for patients with alopecia areata (AA). We present here a successful immunotherapy for AA female case with atopic diathesis, using oral antihistamine and topical corticosteroid supportively on DPCP. Courses of clinical and laboratory findings suggested that indirect effect to allergic inflammation by antihistamine drugs contributed to AA regression in our case.

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Alopecia Areata

Cited by 521 publications

References 88 publications

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Three hundred and eight nanometer excimer light therapy for alopecia universalis that is resistant to other treatments: A clinical study of 11 patients

Biologic: A Double Edged Sword - A Case of Etanercept Induced Alopecia Areata in a Patient with Psoriasis Vulgaris

Successful Treatment of Multiple Alopecia Areata With Contact Immunotherapy: Supportive Usage of Oral Antihistamine and Topical Corticosteroid

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