Alopecia Areata and Associated Diseases in Saudi Patients

Al-Khawajah, Marwan M.

doi:10.5144/0256-4947.1991.651

Cited by 10 publications

(12 citation statements)

References 23 publications

(35 reference statements)

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“…A previous local study showed an association between AA and thyroid disease [21]. Atopic diseases were common in our patients, which is in agreement with the findings of Al-Khawajah's study [13].…”

Section: Discussionsupporting

confidence: 93%

“…Treatment response varies depending on the severity of AA, age of onset, and other factors [11,12]. Despite AA being commonly seen in daily practice among Saudi patients, studies are limited and outdated in our population [13]. is study aims to describe the prevalence and clinical characteristics of patients diagnosed with AA at King Abdulaziz Medical City in Riyadh, Saudi Arabia.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence and Clinical Characteristics of Alopecia Areata at a Tertiary Care Center in Saudi Arabia

Alshahrani

AlTuwaijri

Abuoliat

et al. 2020

Dermatology Research and Practice

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Introduction. Alopecia areata (AA) is a common autoimmune disorder of hair follicles characterized by patches on nonscarring hair loss. Reports of prevalence and clinical characteristic of AA in Saudi Arabia are limited. The aim of our study is to describe the prevalence and clinical characteristics of Saudi patients with AA. Materials and Methods. A retrospective cross-sectional study was conducted at King Abdulaziz Medical City in Riyadh, Saudi Arabia. All patients diagnosed with AA between January 2016 and December 2017 were included. Data included patient demographics, type of AA, disease duration, family history of AA, and comorbid autoimmune diseases. Results. A total of 216 patients with AA were included. The overall prevalence of AA was approximately 2.3%. The mean disease duration at the time of presentation was 2 months while the mean age of onset was 25.61 years. The most common type of AA in both adult and pediatric groups was the patchy type involving the scalp. Comorbid diseases were found in 32.41% of patients. Common associated conditions included hypothyroidism, diabetes mellitus, and atopic diseases. Conclusion. The overall prevalence of AA among a population of Saudi patients is 2.3%. AA prevalence is higher in pediatrics than adults. Common comorbid conditions include hypothyroidism, diabetes mellitus, and atopic diseases.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Prevalence and Clinical Characteristics of Alopecia Areata at a Tertiary Care Center in Saudi Arabia

Alshahrani

AlTuwaijri

Abuoliat

et al. 2020

Dermatology Research and Practice

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“…9,28,29 The prevalence of accompanying atopy was found to be compatible with that in the literature. 8,25,[29][30][31] In a study conducted by Koçak et al on 100 patients with AA, 6 (15%) patients were found to have a coexisting autoimmune disease. 32 Similarly, the present study found an autoimmune disease in 26 patients (17%).…”

Section: Discussionsupporting

confidence: 86%

Correlations Between the Clinical and Sociodemographic Characteristics of Patients with Alopecia Areata

Ergin¹,

Arıca²,

Yaylı³

et al. 2016

Turkiye Klinikleri J Dermatol

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lopecia areata (AA) is a chronic inflammatory disease that affects hair follicles and, in certain cases, nails. The etiopathogenesis of the disease is not clearly known, but AA is considered to be an autoimmune disease that occurs due to genetic predisposition. 1-4 Genetic structure and nonspecific immune and organ-specific autoimmune reactions, partic-Correlations Between the Clinical and Sociodemographic Characteristics of Patients with Alopecia Areata A AB BS S T TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Alopecia areata (AA) is a chronic inflammatory disease that affects hair follicles. This study aimed to determine the clinical and sociodemographic characteristics of patients with AA, and the correlations between them. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A hundred and fifty three AA patients (49 female and 104 male with a mean age 28 years) were included in the study. Their sociodemographic characteristics, clinical data and etiologic data were recorded. The severity of disease was determined using Severity of Alopecia Tool (SALT) scores. R Re es su ul lt ts s: : Mean SALT scores increased significantly in patients whose onset of the disease was in the childhood, and in patients who had multiple episodes of AA previously. Mean SALT scores also increased for patients with a positive family history of AA, nail involvement, ophiasis, nevus flammeus or autoimmune diseases (p< 0.05). No significant difference was found between SALT scores, and sex and presence of atopy. C Co on nc cl lu us si io on n: : Early stages of the disease, positive family history of AA, the presence of the nail involvement, nevus flammeus, ophiasis, and autoimmune diseases were associated with severe involvement in this study. Considering the correlation between these factors in patient management is thought to be helpful in selecting a more appropriate and effective treatment. K Ke ey y W Wo or rd ds s: : Alopecia areata; demography; hair; scalp Ö ÖZ ZE ET T A Am ma aç ç: : Alopesi Areata (AA) kıl folikülünü etkileyen kronik inflamatuar bir hastalıktır. Bu çalışmada Alopesi Areatalı hastaların klinik ve sosyodemografik özellikleri ile bu özellikler arası ilişkilerin belirlenmesi amaçlandı. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Çalışmaya yaş ortalamaları 28 yıl olan 153 (49 kadın, 104 erkek) AA tanılı hasta dâhil edildi. Hastaların sosyo demografik özellikleri, klinik ve etiyolojik verileri kaydedildi. Hastalığın şiddetinin belirlenmesinde Severity of Alopecia Tool (SALT) skoru kullanıldı. B Bu ul lg gu ul la ar r: : Ortalama SALT skoru, hastalık başlangıç yaşı çocukluk döneminde olan ve daha önce birden fazla atak geçiren hastalarda anlamlı derecede daha yüksek bulundu. Pozitif aile öyküsü, tırnak tutulumu, ofiazis, nevus flammeus varlığı veya otoimmün hastalık varlığı olan hastalarda SALT skoru yüksekti (p <0,05). Cinsiyet ve atopi varlığı ile SALT skoru arasında istatistiksel açıdan anlamlı bir farklılık saptanmadı. S So on nu uç ç: : Bu çalışmada hastalık başlangıç yaşı, pozitif AA aile öyküs...

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“…One study (92 AA patients and 88 control patients) reported a statistically significant positive association between AA and atopy ( p = 0.015) [22], while another ( n = 215) described a significant negative association ( p = 0.008), with non-AA patients having a higher prevalence of atopy (34%) than AA patients (20%) [23]. However, 2 other studies failed to identify any significant relationship [19, 24].…”

Section: Resultsmentioning

confidence: 99%

The Immunological Association between Alopecia Areata and Respiratory Diseases: A Systematic Review

Sung

Choi

Juhász

et al. 2019

Skin Appendage Disord

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Background: While alopecia areata (AA) has been associated with atopy, the immunological relationship is unclear, with the association of specific atopic and systemic respiratory diseases not established. The relationship between T-helper (Th)1-mediated AA and Th2-mediated atopy challenges the conventional Th1/Th2 paradigm of autoimmune disease categorization. Objectives: To determine the association between AA and atopic respiratory diseases in adults and children, and respiratory diseases in general. Method: All primary literature, excluding case reports, were identified within PubMed/MEDLINE, CINAHL, and Web of Science in May 2018 using the following search terms: “(alopecia OR hair loss) AND (respiratory OR pulmonary OR lungs OR asthma OR rhinitis OR bronchitis OR COPD OR atopy OR atopic).” Information from 32 articles meeting the inclusion and exclusion criteria was reviewed. Results: Among the 32 articles identified for inclusion, the prevalence of AA was more strongly associated with allergic rhinitis compared to asthma among pediatric and adult populations. While a significant association was identified between AA, allergic rhinitis, and a late age of onset, the association of AA and asthma remains controversial despite asthma’s prevalence among AA patients. No significant difference was identified with regard to the association of AA and non-atopic respiratory diseases between adult and pediatric patients. Conclusions: Adult and pediatric patients with AA warrant further workup for atopic respiratory diseases such as allergic rhinitis. AA may have an underlying Th2-mediated immunological component, which supports its association with atopic respiratory diseases and provides a new avenue for targeted therapies in select cases.

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Alopecia Areata and Associated Diseases in Saudi Patients

Cited by 10 publications

References 23 publications

Prevalence and Clinical Characteristics of Alopecia Areata at a Tertiary Care Center in Saudi Arabia

Prevalence and Clinical Characteristics of Alopecia Areata at a Tertiary Care Center in Saudi Arabia

Correlations Between the Clinical and Sociodemographic Characteristics of Patients with Alopecia Areata

The Immunological Association between Alopecia Areata and Respiratory Diseases: A Systematic Review

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