Aloe vera leaf gel: a review update

Reynolds, Tom; Dweck, Anthony C.

doi:10.1016/s0378-8741(99)00085-9

Cited by 665 publications

(521 citation statements)

References 170 publications

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“…As is in the present study, other workers have reported antibacterial properties of ethanol extracts of A. vera gel against the pathogens selected in the study (1,24). In the study conducted by Martinez et al (18) no antimicrobial activity was reported using, aqueous extract of A. vera leaves.…”

Section: Antibacterial Activity Of Aloe Vera Gel Extract Against Selesupporting

confidence: 56%

“…To date more than 75 ingredients have been identified from Helicobacter pylori and Salmonella typhi (16,23,24,27).…”

Section: Introductionmentioning

confidence: 99%

“…Whole leaf components are proposed to have direct antibacterial properties include anthraquinones and saponin (24,27); While polysaccharides have been attributed within direct bacterial activity through the stimulation of phagocytic leucocytes to destroy bacteria (16,23).Due to the increasing development of antibiotic resistance, the emphasis of the present study is being given on the use of Aloe vera as a natural remedy for the inhibition of various infections and to identify the different compounds.…”

Section: Introductionmentioning

confidence: 99%

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Isolation, Purification and Evaluation of Antibacterial Agents from Aloe vera

Lawrence

Tripathi²,

Jeyakumar³

2009

Braz. J. Microbiol.

139

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The ethanol, methanol and acetone extracts of Aloe vera gel were studied for their antimicrobial activity against four Gram-positive and Gram-negative bacteria using agar well diffusion method. The extracts showed varied levels of antimicrobial activity against the tested pathogens. The ethanol and methanol extracts showed higher activity while acetone extract, showed least or no activity against most of the tested pathogens. Fractions obtained from the extracts by Thin Layer and Column Chromatography were studied for their antagonistic properties using Spot Assay Technique. Compounds with maximum antibacterial activity isolated from the ethanol and methanol extracts were identified as p -coumaric acid (Mol. wt.165), ascorbic acid (Mol. wt.177 ), pyrocatechol (Mol. wt.110 ) and cinnamic acid (Mol.wt.148), on the basis of Gas Chromatography Mass Spectrometry. The study suggests the antimicrobial activity of the A. vera gel extract to be dependant on the synergistic effect of different compounds. With the broad spectral antimicrobial effect of A. vera gel, it could be further recommended in the treatment of various bacterial diseases.

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Section: Antibacterial Activity Of Aloe Vera Gel Extract Against Selesupporting

confidence: 56%

“…To date more than 75 ingredients have been identified from Helicobacter pylori and Salmonella typhi (16,23,24,27).…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Isolation, Purification and Evaluation of Antibacterial Agents from Aloe vera

Lawrence

Tripathi²,

Jeyakumar³

2009

Braz. J. Microbiol.

139

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“…Aloe vera is a plant of the Liliaceas family, popularly known as babosa and has potentially active components including amino acids, sugars, enzymes, vitamins and minerals that have important properties such as tissue penetration, anti-inflammatory effect, and immunoregulatory function, in addition to antimicrobial, healing and regenerative properties 7,8 .…”

Section: Introductionmentioning

confidence: 99%

Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Fé

Coelho

Damascena

et al. 2014

Rev. odontol. UNESP

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AIM: Mineral trioxide aggregate (MTA) was associated to Aloe vera to verify the coadjutant action of that medicinal plant in the bone neoformation process in tibia of rats.MATERIAL AND METHOD: 36 male rats (Rattus norvegicus) were used, divided into two groups of 18 rats each. Two circumferential bone defects with approximately 5 mm in diameter were made on the right tibia of each animal: the upper defect was filled with blood coagulates in both groups to serve as experimental control and the lower defect was filled with MTA and Aloe vera in experimental (group E1) and MTA and distilled water in experimental (group E2). Seven, 15 and 30 days after surgery, six animals from each group were euthanized and the right tibia of each animal was removed for histological analysis.RESULT: Histologically, experimental group E1 presented better results for the two variables, inflammation [at seven days (p=0.045)] and bone formation [at seven days (p=0.018) and 30 days (p=0.034)], compared to the E2 group.CONCLUSION: The association of MTA and Aloe vera showed potential to reduce the effects of the inflammatory cascade and promote bone neoformation making it to a promising proposal for future use in endodontic therapy.

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“…31 Moreover, AV enhances production of kGF-1 and VEGF by g ing ival fibroblasts 32 and maintaines the wound moisturized, promotes epithelial cell migration, and enhances collagen maturation. 33 AgNPs exerts its healing effect by decreasing bacterial and fungal count at wound site. The mechanisms are through disruption of the cell membrane causing cell death and the ability to block respiratory enzyme pathways, alter microbial DNA and inhibit the normal fungal budding process.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice

El-Batal

Ahmed

2018

Braz. oral res.

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Radiation combined injury, a life-threatening condition, has higher mortality than simple radiation injury. The aim of the present study was to analyze the efficiency of Aloe vera and silver nanoparticles in improving the healing of ulcerated oral mucosa after irradiation. Thirty male Albino mice were divided into five groups: control, radiation, Aloe vera (AV), silver nanoparticles (NS), and AV+NS. The mice were exposed to whole body 6Gy gamma-radiation. After one hour, 20% acetic acid was injected into the submucosal layer of the lower lip for ulcer induction. The animals received topical treatment with the assigned substances for 5 days. Lip specimens were subjected to hematoxylin and eosin and anti alpha-smooth muscle actin immunohistochemical staining. Results demonstrated occurance of ulcer three days post irradiation in all groups except in the AV+NS group where only epithelial detachment was developed. After seven days, data revealed persistent ulcer in radiation group, and almost normal epithelium in the AV+NS group. A significant reduction of epithelial thickness was detected in all groups at the third day as compared to control. At the seventh day, only the AV+NS group restored the epithelial thickness. Area percent of alpha-smooth muscle actin expression was significantly decreased in radiation group at the third day followed by significant increase at the seventh day. However, all treatment groups showed significant increase in alpha-smooth muscle actin at the third day, which decreased to normal level at the seventh day. Our study demonstrated the efficiency of Aloe vera and silver nanoparticles in enhancing ulcer healing after irradiation.

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Aloe vera leaf gel: a review update

Cited by 665 publications

References 170 publications

Isolation, Purification and Evaluation of Antibacterial Agents from Aloe vera

Isolation, Purification and Evaluation of Antibacterial Agents from Aloe vera

Aloe vera as vehicle to mineral trioxide aggregate: study in bone repair

Therapeutic effect of Aloe vera and silver nanoparticles on acid-induced oral ulcer in gamma-irradiated mice

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