Aloe-emodin-loaded SBA-15 and its in vitro release properties and cytotoxicity to cervical cancer cells

Jangra, Suman; Sharma, Bharti; Singh, Saravjeet

doi:10.1080/14328917.2020.1790181

Cited by 9 publications

(5 citation statements)

References 49 publications

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“…Thus, researches are urged to enhance its oral bioavailability, improve tumor-targeting property, and reduce the toxicity to normal cells ( Şeker Karatoprak et al, 2022 ). One in vitro study reported that AE-loaded in SBA-15 demonstrated better water solubility, and exhibited particular toxicity on HeLa cells and little effect on the normal cervical cells ( Jangra et al, 2021 ), but extensive in vivo researches are required before its clinical implications.…”

Section: Discussionmentioning

confidence: 99%

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells

Shi

Liu

et al. 2022

Front. Pharmacol.

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Aloe-emodin (1,8-dihydroxy-3-hydroxymethyl-anthraquinone), derived from some Chinese edible medicinal herbs, exerts a potential anticancer activity on various cancer cells, making it a drug candidate for cancer therapy. Yet, the role of aloe-emodin in pyroptosis, a new type of cell death, is uncharacterized. In this study, we explored the molecular mechanisms of aloe-emodin-triggered pyroptosis. Aloe-emodin inhibited proliferation and migration and triggered caspase-dependent cell death of HeLa cells in a dose-dependent manner. Aloe-emodin caused mitochondrial dysfunction and induced pyroptosis by activating the caspase-9/3/GSDME axis. Transcriptional analysis showed extensive changes in gene expressions in cellular pathways, including MAPK, p53, and PI3K-Akt pathways when treated with aloe-emodin. This study not only identified a novel role of aloe-emodin in pyroptotic cell death, but also performed a systematical genome-wide analysis of cellular pathways responding to aloe-emodin, providing a theoretical basis for applying anthraquinone derivatives in the treatment of GSDME-expressing cancers.

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Section: Discussionmentioning

confidence: 99%

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells

Shi

Liu

et al. 2022

Front. Pharmacol.

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“…Jangra et al aimed to increase the bioavailability of aloe emodin extracted from leaves of Aloe vera with SBA-15 particles and to examine its in vitro release properties and cytotoxic effect on HeLa cell line. It was found that these nanoscale SBA-15 particles showed significant potential for antineoplastic effect by destroying the nucleus of cancer cells [ 114 ]. It can be said that SBA-15, which clinically increases the effectiveness of anticancer drugs such as aloe emodin, is a new alternative option that can be applied.…”

Section: Nanocarrier-based Application Of Aloe Emodinmentioning

confidence: 99%

Advances in Understanding the Role of Aloe Emodin and Targeted Drug Delivery Systems in Cancer

Karatoprak

Akkol

Yücel

et al. 2022

Oxidative Medicine and Cellular Longevity

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Cancer is one of the important causes of death worldwide. Despite remarkable improvements in cancer research in the past few decades, several cancer patients still cannot be cured owing to the development of drug resistance. Natural sources might have prominence as potential drug candidates. Among the several chemical classes of natural products, anthraquinones are characterized by their large structural variety, noticeable biological activity, and low toxicity. Aloe emodin, an anthraquinone derivative, is a natural compound found in the roots and rhizomes of many plants. This compound has proven its antineoplastic, anti-inflammatory, antiangiogenic, and antiproliferative potential as well as ability to prevent cancer metastasis and potential in reversing multidrug resistance of cancer cells. The anticancer property of aloe emodin, a broad-spectrum inhibitory agent of cancer cells, has been detailed in many biological pathways. In cancer cells, these molecular mechanisms consist of inhibition of cell growth and proliferation, cell cycle arrest deterioration, initiation of apoptosis, antimetastasis, and antiangiogenic effect. In accordance with the strategy of developing potential drug candidates from natural products, aloe emodin’s low bioavailability has been tried to be overcome by structural modifications and nanocarrier systems. Consequently, this review summarizes the antiproliferative and anticarcinogenic properties of aloe emodin, as well as the enhanced activity of its derivatives and the advantages of drug delivery systems on bioavailability.

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“…Emodin [90] II or IV [91,92] Poor [93,94] Low [95] 270.24 and 266-268 Improves glucose tolerance, insulin action, multiple genes function expression (dysregulated during diabetes). AMP-activated protein kinase involvement, alleviates endoplasmic reticulum stress, anti-inflammatory and anti-oxidant effects for improved insulin sensitivity and better blood glucose clearance [136,137].…”

Section: Glycosidesmentioning

confidence: 99%

A Mechanistic Insight on Phytoconstituents Delivering Hypoglycemic Activity: A Comprehensive Overview

Raghav

Kumar

Sethiya

et al. 2022

Future Pharmacology

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Diabetes is a long-term (chronic), challenging lifestyle (metabolic) disorder in which the body cannot regulate the amount of sugar in the blood and majorly affecting endocrine system and metabolic functions. Its complications majorly affect the neurons (as developing neuropathy), kidney (as nephropathy), and eye (as retinopathy). Diabetes also results in other associated problems, such as diabetic foot ulcers, sexual dysfunction, heart diseases etc. In the traditional medicines, the search for effective hypoglycemic agents is a continuous and challenging approach. Plant-derived bioactives, including alkaloids, phenols, glycosides, anthocyanins, flavonoids, saponins, tannins, polysaccharides, and terpenes, have been established to target cellular and molecular mechanisms involved in carbohydrate metabolism. Numerous diabetic patients select the herbal or traditional medicine system as an alternative therapeutic approach along with the mainstream anti-diabetic drugs. However, due to restrictive hurdles related to solubility and bioavailability, the bioactive compound cannot deliver the requisite effect. In this review, information is presented concerning well researched phytoconstituents established as potential hypoglycemic agents for the prevention and treatment of diabetes and its associated disorders having restricted solubility and bioavailability related issues. This information can be further utilized in future to develop several value added formulation and nutraceutical products to achieve the desired safety and efficacy for the prevention and treatment of diabetes and its related diseases.

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Aloe-emodin-loaded SBA-15 and its in vitro release properties and cytotoxicity to cervical cancer cells

Cited by 9 publications

References 49 publications

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells

Aloe-Emodin Induces Mitochondrial Dysfunction and Pyroptosis by Activation of the Caspase-9/3/Gasdermin E Axis in HeLa Cells

Advances in Understanding the Role of Aloe Emodin and Targeted Drug Delivery Systems in Cancer

A Mechanistic Insight on Phytoconstituents Delivering Hypoglycemic Activity: A Comprehensive Overview

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