Almanac 2013: acute coronary syndromes

Meier, Pascal; Lansky, Alexandra J.; Baumbach, Andreas

doi:10.1136/heartjnl-2013-304649

Cited by 9 publications

(6 citation statements)

References 64 publications

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“…ACS includes myocardial infarction with stent thrombosis (ST)-segment elevation, myocardial infarction without ST-segment elevation, and unstable angina (1). Unstable coronary artery plaque is the most common cause of ACSs and it can appear as the myocardial infarction with ST-segment elevation, myocardial infarction without ST-segment elevation, and unstable angina; it can also appear as sudden heart attack due to ischemia caused by tachyarrhythmias (2).…”

Section: Introductionmentioning

confidence: 99%

Effect of Foot Reflexology Massage and Foot Bath on the Sleep Quality of Patients with Acute Coronary Syndrome: A Comparative Study

Naseri¹,

Rahmani²,

Nerir³

et al. 2016

Crit Care Nurs J

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Objectives: Cardiovascular diseases, especially coronary artery diseases, result in sleep disturbance. Myocardial muscle oxygen demand rises in sleep disturbance. Also, the possibility of cardiovascular risks such as re-infarction and dysrhythmias increases. As a result, removing sleep disorders is very important. The current study aimed at assessing the effect of foot reflexology massage and foot bath methods on sleep quality of the patients with acute coronary syndrome (ACS) through a comparative study. Methods:The current semi-experimental study was conducted on 3 groups of patients with ACS admitted to coronary care units (CCUs) of Baqiyatallah (AJ) hospital of Tehran, Iran. Samples of the study included 35 patients for each group (105 patients in all the groups) selected among the available hospitals and divided into 3 groups (foot reflexology massage, foot bath, and control) through random allocation. According to the related program, patients of the intervention groups were under intervention for 2 nights from the 2nd night of hospitalization and sleep quality was assessed through Verran and Snyder-Halpern (VSH) subjective sleep quality questionnaire before and after the intervention. Then, data analysis was done through SPSS version21 by descriptive and inferential statistics. Results: There was no significant statistical difference among the 3 groups regarding sleep disturbance and supplementary sleep after interventions (P > 0.05), but there was a significant statistical difference between the groups and at different time regarding the effectiveness after intervention (P < 0.05). The obtained results indicated that each of the interventions alone can result in improvement of sleep quality, but there was no significant statistical difference among them. Conclusions: Foot massage and foot bath positive effect on the sleep quality of patients with ACS can be used as a complementary action.

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Section: Introductionmentioning

confidence: 99%

Effect of Foot Reflexology Massage and Foot Bath on the Sleep Quality of Patients with Acute Coronary Syndrome: A Comparative Study

Naseri¹,

Rahmani²,

Nerir³

et al. 2016

Crit Care Nurs J

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“…NSTEMI is the most common form of acute coronary syndromes, and also associated with high mortality rates. Early treatment is crucial for the favorable prognosis of the disease 11 …”

Section: Discussionmentioning

confidence: 99%

Evans syndrome with non-ST segment elevation myocardial infarction complicated by hemopericardium

Kızılırmak

Demir

Çakal

et al. 2016

Indian Heart Journal

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Evans syndrome (ES) is a rare hematological disease characterized by autoimmune hemolytic anemia, immune thrombocytopenia, and/or neutropenia, all of which may be seen simultaneously or subsequently. Thrombotic events in ES are uncommon. Furthermore, non-ST segment-elevation myocardial infarction (NSTEMI) during ES is a very rare condition. Here, we describe a case of a 69-year-old female patient presenting with NSTEMI and ES. Revascularization via percutaneous coronary intervention (PCI) was scheduled and performed. Hemopericardium and cardiac tamponade occurred 5h after PCI, and urgent pericardiocentesis was performed. Follow-up was uneventful, and the patient was safely discharged. Early recognition and appropriate management of NSTEMI is crucial to prevent morbidity and mortality. Coexistence of NSTEMI and ES, which is associated with increased bleeding risk, is a challenging scenario and these patients should be closely monitored in order to achieve early recognition and treatment of complications.

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“…The tissue levels of the five oxidative stress markers: SOD, CAT, GSH, GPX and LPO in the four groups of study rats are listed in Table 2. ISPH-treated group-II rats had significant decrease in SOD [F (3,20)…”

Section: Quantification Of Oxidative Stress Markersmentioning

confidence: 99%

“…It is caused by the metabolic imbalance involving elevated energy requirements and deficient oxygen supply to the cardiac myocytes, ultimately leading to myocardial necrosis [2]. MI is closely associated with several changes in metabolic and signaling pathways that involve increased oxidative stress, elevated lipid peroxidation, excessive cytoplasmic/mitochondrial calcification, disturbed antioxidant homeostasis, dynamic cellular metabolism, irreversible DNA damage and other pathophysiological alterations [3]. The mechanism of pharmacological action exhibited by modern western medicines revolves around the lock-and-key model that entails the action of a single therapeutic agent against a single target to regulate a particular metabolic/signaling pathway, thereby failing to treat diseases governed by multiple molecular mechanisms [4].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of PKCβ Mediates Cardioprotective Activity of Ambrex against Isoproterenol-Induced Myocardial Necrosis: in vivo and in silico Studies

Ravindran¹,

Kumar²,

Rajkumar³

et al. 2018

Biol Med

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Aims and objectives:The current study characterized the morphology of Ambrex formulation by Scanning Electron Microscopy and assessed its cardioprotective activity against Isoproterenol (ISPH)-induced myocardial necrosis in rats by biochemical and histopathological evaluations, and also attempted to predict the prospective protein-targets of Ambrex and the signaling pathway that mediates this activity through molecular docking approach.Materials and methods: Sprague-Dawley male rats (4 groups, 6 rats per group) chosen for the current study were acclimatized to the laboratory conditions for 7 days prior to actual treatment; they were pretreated with Ambrex (40 mg/kg b.wt/day, p.o) everday for 21 days and then intoxicated with ISPH (85 mg/kg b.wt, s.c) on day-20 and 21 to experimentally induce myocardial necrosis. The extent of ISPH-induced myocardial necrosis was quantified in terms of the serum levels of two cardiac biomarkers: creatine kinase-MB and lactate dehydrogenase. The extent of ISPH-induced oxidative stress was quantified in terms of the tissue levels of five oxidative stress biomarkers: superoxide dismutase, catalase, reduced glutathione, glutathione peroxidase and lipid peroxidation. Results and discussion:The Scanning Electron Microscopy image of Ambrex formulation showed the formation of nanoparticles with thickness of 65 nm, making Ambrex a unique metal-deficient Siddha-medicine based polyherbal nano-formulation characterized and evaluated in India. Pretreatment with Ambrex attenuated the extent of ISPH-induced oxidative stress, lipid peroxidation and generation of reactive oxygen species as reflected by biochemical evaluations, and also ameliorated the degree of ISPH-induced myocardial necrosis and membrane damage as reflected by histopathological evaluations. The results of molecular docking revealed that Withaferin-A and Methyl Commate-A (the key metabolites of Withania somnifera and Ambrex respectively) inhibit Protein Kinase-C Beta, and renders Ambrex its cardioprotective activity by maintaining the intracellular antioxidant homeostasis and myocardial membrane architecture.

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Almanac 2013: acute coronary syndromes

Cited by 9 publications

References 64 publications

Effect of Foot Reflexology Massage and Foot Bath on the Sleep Quality of Patients with Acute Coronary Syndrome: A Comparative Study

Effect of Foot Reflexology Massage and Foot Bath on the Sleep Quality of Patients with Acute Coronary Syndrome: A Comparative Study

Evans syndrome with non-ST segment elevation myocardial infarction complicated by hemopericardium

Inhibition of PKCβ Mediates Cardioprotective Activity of Ambrex against Isoproterenol-Induced Myocardial Necrosis: in vivo and in silico Studies

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