A series of N-(3-chloro-2-oxo-4-arylazetidin-1-yl)-2-[(4-oxo-2-aryl-4H-chromen-7-yl)oxy]acetamide
derivatives [SLP VI 1(a-d)-2(a-d)] were synthesized from 7-hydroxy flavone derivatives through the
intermediate Schiff bases. The synthesized compounds were investigated for in vitro antioxidant property
by DPPH radical scavenging assay. The title compounds with good antioxidant potency were further
evaluated for possible cardioprotective effect by doxorubicin induced cardiotoxicity. All biochemical
changes were normalized after oral administration of the test compounds at the dose of 50 μg/kg. The
results showed the significant (p < 0.05) increase in antioxidant enzymes catalase and superoxide
dismutase in heart tissue homogenates. These observations enable us to conclude that the synthesized
derivatives SLP VI 1b, VI 1c, VI 2b and VI 2d have cardioprotective activity against doxorubicin
induced cardiotoxicity. Further, an attempt has been made to perform in silico studies on the synthesized
compounds to predict the interaction between test ligands and prospective cardiovascular protein targets
using molecular docking tools. The title compounds have good binding affinity with MAPkinase P38
and PKCβ cardiovascular targets.