Allostatic load as a predictor of functional decline

Karlamangla, Arun S.; Singer, Burton H.; McEwen, Bruce S.; Rowe, John W.; Seeman, Teresa E.

doi:10.1016/s0895-4356(02)00399-2

Cited by 412 publications

(343 citation statements)

References 61 publications

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“…Lipsitz has demonstrated loss of complexity in cardiac rhythms and other aspects of physiology (Lipsitz, 2004), but the link to dysregulation is still unclear. Allostatic load studies have quantified what can be interpreted as a global measure of dysregulation (Karlamangla et al ., 2002; Crimmins et al ., 2003; Szanton et al ., 2009), comparable to some of our previous studies using statistical distance. To our knowledge, the only study to explicitly measure multi‐system physiological dysregulation is that of Fried et al .…”

Section: Discussionmentioning

confidence: 99%

“…In particular, much attention is focusing on physiological dysregulation (alternatively referred to as allostatic load or homeostenosis) (McEwen, 1998; Karlamangla et al ., 2002; Crimmins et al ., 2003). While evidence is abundant for increases in various types of physiological dysfunction with age, our use of ‘dysregulation’ is more restricted, as an emergent property of a complex system in the formal sense (Holland, 1992; Kauffman, 1993; Kriete, 2013).…”

Section: Introductionmentioning

confidence: 99%

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Homeostatic dysregulation proceeds in parallel in multiple physiological systems

et al. 2015

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SummaryAn increasing number of aging researchers believes that multi‐system physiological dysregulation may be a key biological mechanism of aging, but evidence of this has been sparse. Here, we used biomarker data on nearly 33 000 individuals from four large datasets to test for the presence of multi‐system dysregulation. We grouped 37 biomarkers into six a priori groupings representing physiological systems (lipids, immune, oxygen transport, liver function, vitamins, and electrolytes), then calculated dysregulation scores for each system in each individual using statistical distance. Correlations among dysregulation levels across systems were generally weak but significant. Comparison of these results to dysregulation in arbitrary ‘systems’ generated by random grouping of biomarkers showed that a priori knowledge effectively distinguished the true systems in which dysregulation proceeds most independently. In other words, correlations among dysregulation levels were higher using arbitrary systems, indicating that only a priori systems identified distinct dysregulation processes. Additionally, dysregulation of most systems increased with age and significantly predicted multiple health outcomes including mortality, frailty, diabetes, heart disease, and number of chronic diseases. The six systems differed in how well their dysregulation scores predicted health outcomes and age. These findings present the first unequivocal demonstration of integrated multi‐system physiological dysregulation during aging, demonstrating that physiological dysregulation proceeds neither as a single global process nor as a completely independent process in different systems, but rather as a set of system‐specific processes likely linked through weak feedback effects. These processes – probably many more than the six measured here – are implicated in aging.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Homeostatic dysregulation proceeds in parallel in multiple physiological systems

et al. 2015

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“…Henry’s original hypotheses have been modified considerably e.g. to the framework of the allostatic load model which describes the health impact of stress and stressful/traumatic events over the life span [74–76]. However, the fundamental assumption that chronic stress has the potential to lead to chronic disease, or at least has a negative impact on the course of chronic disease, is generally accepted.…”

Section: Allostatic Load and Resiliencementioning

confidence: 99%

“…The role of trauma and especially collective trauma has received wide interest, in particular in connection with the allostatic load model. This model predicts that it is the accumulation of stressful events that may lead to a higher vulnerability for disease, such as Alzheimers disease in old age [74,76]. …”

Section: Allostatic Load and Resiliencementioning

confidence: 99%

Sami yoik, Sami history, Sami health: a narrative review

Hämäläinen

Salamonsen

Graff

et al. 2018

International Journal of Circumpolar Health

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Music as a possible health-promoting agent has attained increasing academic and scientific interest over the last decades. Nonetheless, possible connections between indigenous singing traditions and health beyond traditional ceremonial healing practices are still under-researched worldwide.The Sami, the indigenous people living in Northern Fennoscandia, have a distinct ancient vocal music tradition called “yoik” practiced from immemorial times. The Sami share a history of assimilation with many indigenous people. During this period of nearly 400 years, yoik alongside other cultural markers was under hard pressure and even banned at times.Compared to other indigenous people in the Arctic, Sami public health shows few significant unfavourable differences to the majority population. The potential role of yoik as a protective health and resilience factor within the Sami culture is the topic of this review. We suggest a two stage model for the health promoting effects of yoik through i) emotion regulation and stress relief on the level of the individual, and ii) as a socio-cultural resilience factors within the Sami population. This review is to be understood as theory-building review article striving for a scholarly review of the literature.

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“…Biomarkers representing the key physiological players in stress adaptation, namely neuroendocrine, cardiovascular, immune and metabolic systems, have been combined to form composite AL measures (7)(8)(9) . These measures have been shown to predict incident physical decline (10) , cognitive dysfunction, CVD (9) , frailty (11,12) and mortality (13) .…”

mentioning

confidence: 99%

Relationship of serum carotenoid concentrations with allostatic load as a measure of chronic stress among middle-aged adults in the USA

Rosenberg

Park

Eldeirawi

2014

Public Health Nutr.

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Objective: Chronic stress and repeated physiological attempts at stress adaptation may result in 'fatigue' and suboptimal performance of multiple physiological systems, i.e. allostatic load (AL). Although carotenoids have been linked with individual cardiovascular, metabolic and inflammatory biomarkers, little is known about the relationship of carotenoids with the multi-system biomarker measure of stress, AL. The present study examined the association of serum concentrations of carotenoids with AL among middle-aged adults. Design: Cross-sectional. AL score was calculated based on nine risk-rated indicators (systolic and diastolic blood pressure, pulse rate, total and HDL-cholesterol, glycosylated Hb, sex-specific waist-to-hip ratio, albumin and C-reactive protein). Subjects: Middle-aged (45-64 years, n 3387) men and women participants in the Third National Health and Nutrition Examination Survey, NHANES III (1988-1994. Results: Serum b-carotene concentration was inversely associated with high AL after adjusting for age, education, race/ethnicity, serum cotinine, alcohol consumption, physical activity and other carotenoids (a-carotene, b-cryptoxanthin, lycopene, lutein/zeaxanthin). Females in the lowest b-carotene quartile were 2?94 (95 % CI 1?74, 4?94) times and males 2?90 (95 % CI 1?43, 5?89) times as likely to have high AL, compared with peers in the highest quartile (P for linear trend 0?001 and 0?018 for females and males, respectively). Mean serum b-carotene concentrations were also inversely associated with the number of 'high-risk' AL components (P for linear trend ,0?001 and 0?004 for females and males, respectively). Conclusions: Our study adds to evidence linking low b-carotene levels with unfavourable health outcomes.

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Allostatic load as a predictor of functional decline

Cited by 412 publications

References 61 publications

Homeostatic dysregulation proceeds in parallel in multiple physiological systems

Homeostatic dysregulation proceeds in parallel in multiple physiological systems

Sami yoik, Sami history, Sami health: a narrative review

Relationship of serum carotenoid concentrations with allostatic load as a measure of chronic stress among middle-aged adults in the USA

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