Alloreactivity

Eckle, Sidonia B G; Rossjohn, Jamie; McCluskey, James

doi:10.1007/978-1-62703-493-7_1

Cited by 2 publications

(2 citation statements)

References 202 publications

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“…Alloreactivity assay is relatively easy to perform and is commonly used to score APC function of cultured-expanded B cells. However, since the mechanism of alloreactivity is not entirely understood [49], APC function of cultured B cells should be further confirmed by antigen presentation to autologous T cells. Meanwhile, appropriate (positive and negative) controls should always be included in testing APC function and T cell responses to facilitate accurate interpretation.…”

Section: Characteristics and Applicationsmentioning

confidence: 99%

The Prospects of Human CD40L-Activated Antigen-Presenting B Cells

Su¹

2016

OAJMB

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B cells are considered as professional antigen presenting cells (APCs) and being used to induce the activation of cognate T cells. Because the number of primary APC from individuals' blood are limited, in vitro activated and expanded B cells represent a good alternative APC source for studying T cell responses against pathogen or cancer. With the discoveries of T-B collaboration and T cell help for B cell activation, several groups have successfully established CD40L-based methods for generating antigen-presenting B cells. This review aims to overview current representative CD40L-based B cell culture methods with their concomitant characteristics, applications, and significances.

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Section: Characteristics and Applicationsmentioning

confidence: 99%

The Prospects of Human CD40L-Activated Antigen-Presenting B Cells

Su¹

2016

OAJMB

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“…1,2 In 1960s, the discovery of highly polymorphic genes tightly clustered (loci) explained how the T cells elicit a specific Immune response against to foreign antigens (alloreactivity) in specific cells. [3][4][5] The genes mentioned previously are termed as the Major Histocompatibility Complex (MHC) or Human Leukocyte Antigens (HLA) in Homo Sapiens. The molecule coded by MHC behaves as a platform for peptides processed the cells (antigenic presentation); thus, this allows the training of T lymphocytes for their selective recognition.…”

Section: Introductionmentioning

confidence: 99%

Transplant immunology I: mechanisms of rejection in solid organ transplants

Fernández¹,

Delgado²,

Amador³

2022

JSRT

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Non-identical transplants (allogeneic) have been a modern medicine milestone; however, the major pitfall for completed succeed is the recognition of foreign organ by the immune system. The myriad variations in sequence of the molecules of the major histocompatibility complex (MHC) or human leukocyte antigen (HLA) between individuals are the major cause of allograft rejection. Thus, the recognition by the B or T lymphocytes of the receptor occurs in the hypervariable regions of the HLA molecules that triggers to the graft 3 types of rejection: hyperacute, acute, and chronic. In addition, the rejection could be cause antibody-mediated (ABMR), T-cell-mediated (TCMR), or both, which depends on the main branch is cause of rejection. This review will explore the mechanisms mentioned above and give an introductory insight into transplant immunology; thus, preparer the reader to delve into further reviews in a Histocompatibility or Immunogenetics laboratory purpose.

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Alloreactivity

Cited by 2 publications

References 202 publications

The Prospects of Human CD40L-Activated Antigen-Presenting B Cells

The Prospects of Human CD40L-Activated Antigen-Presenting B Cells

Transplant immunology I: mechanisms of rejection in solid organ transplants

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