Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model

Zhou, Jiangqiao; Qiu, Tao; Zhang, Lu; Chen, Zhong-bao; Wang, Zhishun; Ma, Xiaoxiong; Li, Dongyu

doi:10.1590/s0102-865020160030000005

Cited by 22 publications

(18 citation statements)

References 26 publications

(22 reference statements)

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“…Class Ia DAMPs such as HMGB1 and HSPs are generated in reperfusion‐injured organs including human renal allografts , but also emitted under BD conditions . These molecules considerably contribute to creation of sterile inflammation including IRI‐mediated inflammation when sensed by those members of the NLR or ALR family that form inflammasomes .…”

Section: A Plethora Of Damps and An Attempt To Classify Themmentioning

confidence: 99%

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

Land

Agostinis

Gasser

et al. 2016

American Journal of Transplantation

131

110

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Upon solid organ transplantation and during cancer immunotherapy, cellular stress responses result in the release of damage-associated molecular patterns (DAMPs). The various cellular stresses have been characterized in detail over the last decades, but a unifying classification based on clinically important aspects is lacking. Here, we provide an in-depth review of the most recent literature along with a unifying concept of the danger/injury model, suggest a classification of DAMPs, and review the recently elaborated mechanisms that result in the emission of such factors. We further point out the differences in DAMP responses including the release following a heat shock pattern, endoplasmic reticulum stress, DNA damage-mediated DAMP release, and discuss the diverse pathways of regulated necrosis in this respect. The understanding of various forms of DAMPs and the consequences of their different release patterns are prerequisite to associate serum markers of cellular stresses with clinical outcomes.

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Section: A Plethora Of Damps and An Attempt To Classify Themmentioning

confidence: 99%

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

Land

Agostinis

Gasser

et al. 2016

American Journal of Transplantation

131

110

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“…After two hours of reperfusion, blood samples were collected by inferior vena cava puncture to measure blood urea nitrogen (BUN) and creatinine (Cr) 11 and evaluating oxidative stress by measurement of thiobarbituric acid reactive substances (TBARS) in peripheral blood and left kidney tissue fragment 12 .…”

Section: Serum Analysismentioning

confidence: 99%

Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats

Brito

Yasojima

Percário³

et al. 2017

Acta Cir. Bras.

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“…Gomes et al 18 demonstrates I/R-induced inflammation reduction, when comparing the efficiency of allopurinol in reducing serial concentration of tumor necrosis factors, of the I/R group, with groups submitted to I/R and treated with allopurinol. Allopurinol also displayed significant advantages in reducing injury by reperfusion in the kidneys of rats, which was demonstrated by Keel et al 19 , by the utilization of 8-isoprostane as oxidative stress marker in the evaluation of injury by I/R; Zhou et al 20 evidenced improvement in kidney function and histology. In a small-intestine I/R model, histological analysis demonstrated allopurinol, administered before ischemia and reperfusion, to display moderate intestinal mucosa damage, and smaller production of malondialdehyde, when compared to the control group 21 .…”

mentioning

confidence: 94%

The influence of allopurinol and post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion in Wistar rats

Akahane

Gomes²,

Paludo³

et al. 2017

Acta Cir. Bras.

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1 AbstractPurpose: To analyze the effects of allopurinol and of post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion. Methods: Thirty rats were used. They were divided in 5 groups: (1) group A: abdominal aortic dissection only, (2) group B: ischemia and reperfusion, (3) group C: administered allopurinol (100mg/Kg) a few hours before procedure, (4) group D: post-conditioned and (5) group E: administered allopurinol and post-conditioned. With the exception of group A, all groups were submitted to infrarenal aortic ischemia for 2 hours, and reperfusion for 72 hours. After euthanasia, lungs were removed for histological analysis. They were graded under two scores: pulmonary injury (neutrophil infiltration, interstitial edema, vascular congestion, and destruction of lung architecture) and lymphocytic score (neutrophil infiltration, lymphoid aggregate and secondary follicle). Results: On the pulmonary injury score, the degree of injury was smaller than in groups D and E, when compared to group B, p<0.05. Group C did not obtain the same result (p>0,05). On the lymphocytic score, there was no statistic difference among groups, p>0.05. Conclusion: Both post-conditioning and the combination of allopurinol and post-conditioning were effective in remote lung protection induced by lower-limbs I/R. When used in isolation, allopurinol showed no protective effect.

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Allopurinol preconditioning attenuates renal ischemia/reperfusion injury by inhibiting HMGB1 expression in a rat model

Cited by 22 publications

References 26 publications

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

Transplantation and Damage-Associated Molecular Patterns (DAMPs)

Effects of hypertonic saline solution associated to remote ischemic perconditioning in kidney ischemia/reperfusion injury in rats

The influence of allopurinol and post-conditioning on lung injuries induced by lower-limb ischemia and reperfusion in Wistar rats

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