Allopurinol-induced hepatomegaly

Childs, Lucy; Dow, Claire

doi:10.1136/bcr-2012-007283

Cited by 6 publications

(2 citation statements)

References 7 publications

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“…Allopurinol termasuk dalam golongan obat urikostatik dengan mekanisme menghambat kerja enzim XO. Kendati demikian allopurinol memiliki sejumlah efek samping antara lain rash, mual muntah, dan dalam dosis tinggi menyebabkan gangguan fungsi hepar (14). Melinjo merupakan jenis buah dari pohon yang banyak tumbuh didaerah tropis salah satunya Indonesia.…”

Section: Pendahuluanunclassified

Efek Hepatoprotektor Ekstrak Etanol Kulit Melinjo terhadap Ekspresi Gen Alanine Aminotransferase 1 Hepar pada Kondisi Hiperurisemia

Mentari,

Machrina

2023

AVERROUS

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Hiperurisemia dapat menginduksi disfungsionalitas pertukaran natrium dan kalsium dalam mitokondria yang akan menyebabkan produksi reactive oxygen species (ROS). Stres oksidatif berperan dalam penuaan, kerusakan DNA, oksidasi, produksi sitokin inflamasi, dan apoptosis sel. Metabolisme asam urat dikatalisis oleh xhantine oxidase (XO) menghasilkan hydrogen peroxide (H2O2) yang dapat menyebabkan terbentuknya jaringan parut pada hepar. Alanine amniotransferase (ALT) dikodekan oleh gen ALT1/GPT yang diekspresikan oleh sel endotel, Kuffer dan hepatosit. Overekspresi gen ALT1 berkontribusi dalam meningkatkan kadar enzim ALT sebagai marker yang sensitif dan spesifik adanya injuri atau kerusakan hepar. Tujuan menilai efek hepatoprotektor ekstrak etanol kulit melinjo terhadap ekspresi gen alanine aminotransferase 1 hepar pada kondisi hiperurisemia. Metode penelitian ini merupakan penelitian deskriptif yang dilakukan dengan metode telaah literature. Data dan informasi dikumpulkan dari beberapa penelitian yang sudah dilakukan sebelumnya. Hasil ekstrak etanol kulit melinjo mengandung flavonoid sebagai antioksidan, efek hepatoprotektor ekstrak etanol kulit melinjo terbukti dengan menurunkan stress oksidatif dan biomarker inflamasi melalui mekanisme inhibitor terhadap pembentukan XO dan adenosine deaminase (ADA) sehingga menyebabkan penurunan kadar dari asam urat dan melalui penghambatan terhadap terbentuknya XO akan menyebabkan pembentukan ROS menjadi terhambat sehingga kerusakan hepar dapat diminimalisir dan tidak terjadi overekspresi gen ALT1 pada hepar. Kesimpulan kandungan flavonoid pada ekstrak kulit melinjo terbukti berpotensi sebagai hepatoprotektor, dengan menimimalisir kadar enzim ALT akibat tidak terjadinya peningkatan ekspresi gen ALT1, flavonoid dapat memodulasi ROS dan reaksi inflamasi sehingga hepar lebih terproteksi dari kerusakan akibat keadaan hiperurisemia.

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Section: Pendahuluanunclassified

Efek Hepatoprotektor Ekstrak Etanol Kulit Melinjo terhadap Ekspresi Gen Alanine Aminotransferase 1 Hepar pada Kondisi Hiperurisemia

Mentari,

Machrina

2023

AVERROUS

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“…Effective drugs commonly exert rapid effects. However, the alleviation of symptoms is usually short-lived and recurs without continued drug treatment, which causes unwanted side effects (6)(7)(8). Therefore, it is necessary to develop alternative compounds that are more effective and less toxic for managing HUA.…”

Section: Introductionmentioning

confidence: 99%

Identifying the intervention mechanisms of polydatin in hyperuricemia model rats by using UHPLC-Q-Exactive Orbitrap mass spectroscopy metabonomic approach

Ge¹,

Su²,

Wang³

et al. 2023

Front. Nutr.

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IntroductionPolydatin is a biologically active compound found in mulberries, grapes, and Polygonum cuspidatum, and it has uric acid-lowering effects. However, its urate-lowering effects and the molecular mechanisms underlying its function require further study.MethodsIn this study, a hyperuricemic rat model was established to assess the effects of polydatin on uric acid levels. The body weight, serum biochemical indicators, and histopathological parameters of the rats were evaluated. A UHPLC-Q-Exactive Orbitrap mass spectrometry-based metabolomics approach was applied to explore the potential mechanisms of action after polydatin treatment.ResultsThe results showed a trend of recovery in biochemical indicators after polydatin administration. In addition, polydatin could alleviate damage to the liver and kidneys. Untargeted metabolomics analysis revealed clear differences between hyperuricemic rats and the control group. Fourteen potential biomarkers were identified in the model group using principal component analysis and orthogonal partial least squares discriminant analysis. These differential metabolites are involved in amino acid, lipid, and energy metabolism. Of all the metabolites, the levels of L-phenylalanine, L-leucine, O-butanoylcarnitine, and dihydroxyacetone phosphate decreased, and the levels of L-tyrosine, sphinganine, and phytosphingosine significantly increased in hyperuricemic rats. After the administration of polydatin, the 14 differential metabolites could be inverted to varying degrees by regulating the perturbed metabolic pathway.ConclusionThis study has the potential to enhance our understanding of the mechanisms of hyperuricemia and demonstrate that polydatin is a promising potential adjuvant for lowering uric acid levels and alleviating hyperuricemia-related diseases.

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Drug adulteration analysis based on complexation with cyclodextrin and metal ions using ion mobility spectrometry

Liang

Wang

et al. 2023

Journal of Pharmaceutical Analysis

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Allopurinol-induced hepatomegaly

Abstract: SummaryAllopurinol has long been recognised as a cause of hepatotoxicity; however, severe side effects remain rare. We report a case of allopurinol-induced hepatomegaly causing abdominal symptoms in an elderly woman after long-term allopurinol use. BACKGROUND

Cited by 6 publications

References 7 publications

Efek Hepatoprotektor Ekstrak Etanol Kulit Melinjo terhadap Ekspresi Gen Alanine Aminotransferase 1 Hepar pada Kondisi Hiperurisemia

Efek Hepatoprotektor Ekstrak Etanol Kulit Melinjo terhadap Ekspresi Gen Alanine Aminotransferase 1 Hepar pada Kondisi Hiperurisemia

Identifying the intervention mechanisms of polydatin in hyperuricemia model rats by using UHPLC-Q-Exactive Orbitrap mass spectroscopy metabonomic approach

Drug adulteration analysis based on complexation with cyclodextrin and metal ions using ion mobility spectrometry

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