Drug adulteration analysis based on complexation with cyclodextrin and metal ions using ion mobility spectrometry

Ultrafast, Selective, and Highly Sensitive Nonchromatographic Analysis of Fourteen Cannabinoids in Cannabis Extracts, Δ8-Tetrahydrocannabinol Synthetic Mixtures, and Edibles by Cyclic Ion Mobility Spectrometry–Mass Spectrometry

“…Finally, the absence of an internal standard in the quantification of absolute cannabinoid content via MS fragments is another source of systematic errors . Therefore, using internal standards or determination of the ratio between two compounds with similar ionization efficiency might be a promising solution. , With this in mind, we compared the ratio of Δ9-THC/Δ8-THC obtained by the cIMS method and the GC-FID method for the purposes of (i) evaluating the relative quantification capability of the developed cIMS method; (ii) checking whether the protocols of converting CBD ( 4 ) to Δ8-THC ( 2 ) mainly produced Δ8-THC ( 2 ); and (iii) checking whether illegal Δ9-THC ( 3 ) would be produced during Δ8-THC ( 2 ) production. As summarized in Table S9 and shown in Figure e, there was an excellent correlation ( R 2 = 0.999) of measured Δ9-THC/Δ8-THC ratios between the cIMS method and GC-FID method in all samples, except for R #8.…”

Isomerism of Cyclodextrin Tetramer Induced by Alkali Halide Cluster Ions Observed by Ion Mobility Spectrometry–Mass Spectrometry

“…Recent advances in ion mobility spectrometry–mass spectrometry (IMS-MS) enable us to explore the assembly structures and isomerism of various CD assemblies. , With the help of theoretical modeling, IMS-MS can provide the structural evolution of a CD assembly as a function of oligomer size. For example, several IMS-MS studies on CD oligomers with metal cations have successfully identified the channel-like linear assemblies for CD dimers and trimers, while a compact cluster can be formed for larger assemblies starting from trimers. , …”