Allopurinol hepatotoxicity

Chawla, S.K.; Patel, Hamel; Parrino, G. Richard; Soterakis, J.; LoPresti, Philip A.; D’Angelo, William

doi:10.1002/art.1780200817

Cited by 34 publications

(3 citation statements)

References 12 publications

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“… 9 Although allopurinol is associated with minor liver test abnormalities and has been linked to acute liver injury with features of a hypersensitivity reaction, liver tests in our patient remained elevated despite discontinuing allopurinol, and the histopathology was inconsistent with the granulomatous disease characteristic of allopurinol-induced liver injury. 10 …”

Section: Discussionmentioning

confidence: 99%

Colchicine-Induced Hepatotoxicity

Abbott

Sigal

2017

ACG Case Reports Journal

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Drug-induced injury (DILI) is a frequent cause of abnormal liver tests and a leading cause of liver failure in the United States. Colchicine has long been used as a systemic anti-inflammatory agent for treatment of gout by inhibiting mitotic activity and neutrophil function. We present the first case of colchicine-induced hepatoxicity, supported by histopathologic findings characteristic of colchicine-induced injury and resolution of liver enzyme abnormalities after its discontinuation. Colchicine-associated DILI has implications for the evaluation of patients with abnormal liver tests and gout, especially for patients with alcoholism and non-alcoholic fatty liver disease, in whom there is an increased incidence of gout.

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Section: Discussionmentioning

confidence: 99%

Colchicine-Induced Hepatotoxicity

Abbott

Sigal

2017

ACG Case Reports Journal

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“…The underlying mechanism of insult remains unknown and indeed the histopathological findings and pathology of each case seems to be variable 2. Fibrin-ring granulomas have been associated with allopurinol-induced hepatitis, although other differential diagnoses should be investigated, including infection and malignancy 3 4.…”

Section: Discussionmentioning

confidence: 99%

Allopurinol-induced hepatomegaly

Childs

Dow

2012

BMJ Case Reports

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“…Доказана роль мочегонных препаратов в параллельном формировании гиперурикемии и заболеваний мочевыделительной и пищеварительной систем, которые уменьшает проксимальную канальцевую реабсорбцию мочевой кислоты и обладают выраженной гепатотоксичностью [44]. В научной литературе сообщается о развитии гранулематозного гепатита на фоне приёма аллопуринола [45,46].…”

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Hyperuricemia, gout and digestive system pathology: common links of pathogenesis

Konyshko,

Morozova,

Tsurko

et al. 2024

ECG

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The aim: to study and present scientists opinions on the direct and indirect clinical and pathogenetic purine compounds metabolism relationships with the digestive system physiological and pathological processes in normal uric acid levels conditions and in hyperuricemia and gout cases. Material and methods. A comprehensive analysis of available modern scientific official sources and regulatory documents for the last decade in the Scopus, PubMed.com, E-library databases. Conclusion. Based on the modern scientific literature data and numerous studies, we can say that there is a pathogenetic relationship between the level of uric acid and the digestive organs defeat.

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Allopurinol hepatotoxicity

Cited by 34 publications

References 12 publications

Colchicine-Induced Hepatotoxicity

Colchicine-Induced Hepatotoxicity

Allopurinol-induced hepatomegaly

Hyperuricemia, gout and digestive system pathology: common links of pathogenesis

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