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Cited by 10 publications
(3 citation statements)
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“…Of interest, a recent study found the similar protective effect of allopurinol in Marfan mice as we observed, nevertheless, they found that this effect was via reducing aortic xanthine oxidoreductase activity and oxidative stress but not by altering uric acid levels. 53 The different changes in uric acid may attribute to the variation in anesthesia, blood sampling protocols, and detection methods. [54][55][56] Notably, adenine diet-induced TAAD is sex dependent.…”
Section: Discussionmentioning
confidence: 99%
“…Of interest, a recent study found the similar protective effect of allopurinol in Marfan mice as we observed, nevertheless, they found that this effect was via reducing aortic xanthine oxidoreductase activity and oxidative stress but not by altering uric acid levels. 53 The different changes in uric acid may attribute to the variation in anesthesia, blood sampling protocols, and detection methods. [54][55][56] Notably, adenine diet-induced TAAD is sex dependent.…”
Section: Discussionmentioning
confidence: 99%
“…Biochemical, molecular and pharmacological studies have shown that xanthine oxidoreductase (XOR) is also a relevant source of ROS in the cardiovascular system [ 13 , 14 , 15 ]. Although the participation of XOR in WBS has not been reported yet; however, other connective tissue diseases, such as Loeys-Dietz and Marfan syndromes, are associated with increased XOR protein levels in aortic samples [ 16 , 17 ]. Interestingly, ROS generated by hypoxanthine and xanthine oxidase can be inhibited by curcumin (CUR) [ 18 ] as well as verapamil hydrochloride (VER) [ 19 ].…”
Section: Introductionmentioning
confidence: 99%
“…Biochemical, molecular and pharmacological studies further implicate xanthine oxidoreductase (XOR) as a source of ROS in the cardiovascular system (Kinugasa et al, 2003; Engberding et al, 2004; Polito et al, 2021). Although the participation of XOR in WBS is unknown, related diseases as Loeys-Dietz and Marfan syndromes showed XOR protein levels increased in aortic samples (Soto et al, 2020; Rodríguez-Rovira et al, 2022). Previous studies have reported that ROS generated by hypoxanthine and xanthine oxidase were inhibited by curcumin (Akter et al, 2020) and the calcium channel blocker verapamil hydrochloride (Liang et al, 2000).…”
Section: Introductionmentioning
confidence: 99%