Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central precocious puberty

Predieri, Barbara; Luisi, Stefano; Casarosa, Elena; Farinelli, Edoardo; Antoniazzi, Franco; Waśniewska, Małgorzata; Bernasconi, Sergio

doi:10.1007/bf03346693

Cited by 8 publications

(6 citation statements)

References 37 publications

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“…To our knowledge, up to now, two studies have reported data on the HPO response to subcutaneous Triptorelin acetate in girls with precocious sexual development. 18,20 Only one of them 18 was focused on Triptorelin test as a method to diagnose CPP. However, this study was retrospective, no GnRH test as reference standard was used and no E 2 response was assessed.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

High diagnostic accuracy of subcutaneous Triptorelin test compared with GnRH test for diagnosing central precocious puberty in girls

Freire

Escobar

Gryngarten

et al. 2013

Clinical Endocrinology

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Section: Discussionmentioning

confidence: 99%

“…To our knowledge, up to now, two studies have reported data on the HPO response to subcutaneous Triptorelin acetate in girls with precocious sexual development . Only one of them was focused on Triptorelin test as a method to diagnose CPP.…”

Section: Discussionmentioning

confidence: 99%

High diagnostic accuracy of subcutaneous Triptorelin test compared with GnRH test for diagnosing central precocious puberty in girls

Freire

Escobar

Gryngarten

et al. 2013

Clinical Endocrinology

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show abstract

“…Following overnight fasting, the participants were told to arrive at the hospital at approximately 8:00 am. Four to five milliliters of blood were collected (0-min sample), and then the LHRH was injected as an intravenous bolus of 2.5 μg/kg (maximum dose < 100 μg) ( 27 ) via an indwelling catheter. At 30 and 60 min after injection, 2 ml of blood were drawn again.…”

Section: Methodsmentioning

confidence: 99%

Gray Matter Differences Between Premature Pubertal Girls With and Without the Reactivation of the Hypothalamic—Pituitary-Gonadal Axis

Zhang

Tao

et al. 2020

Front. Psychiatry

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The onset of puberty and related hormones exerts significant effects on brain morphometric and psychosocial development. The biological mechanisms underlying how the reactivation of the hypothalamic-pituitary-gonadal (HPG) axis and puberty-related hormonal maturation sculpts human brain architecture remain elusive. To address this question, 105 premature pubertal girls (age 8-11 years) without menstruation underwent brain structural scanning on a 3T MR system, and the luteinizing hormone releasing hormone (LHRH) stimulation test was used to identify the reactivation of the HPG axis. Among the 105 girls, 63 were positive for HPG axis reactivation (HPG+), while the others showed negative (HPG-). Cortical thickness was calculated and compared between the two groups after adjusting for age. The brain regions showing inter-group differences were then extracted and correlated with the peak value of serum hormone after the LHRH stimulation test in entire sample. Compared to HPG-girls, HPG+ girls showed reduced cortical thickness mainly in the the right precuneus, right inferior temporal gyrus, and right superior frontal gyrus, while increased cortical thickness primarily in the left superior parietal lobe and right inferior parietal lobe. Linear-regression analysis revealed negative correlations between the cortical thickness of the right inferior parietal lobe with the peak value of FSH and the right precuneus with LH and E. These findings provide evidence to support the notion that the reactivation of HPG axis and changes of hormones during the early phase of hormonal maturation exert influences on the development of gray matter.

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“…Following overnight fasting, the participants were asked to arrive at the hospital at approximately 8:00 am. LHRH was injected as an intravenous bolus of 2.5 μg/kg (maximum dose < 100 μg) (25) through an indwelling catheter. Four to five milliliters of blood were collected immediately before injection (0-min sample), and then 2 ml were collected at 30 and 60 min after the injection.…”

Section: Methodsmentioning

confidence: 99%

Initiation of the Hypothalamic–Pituitary–Gonadal Axis in Young Girls Undergoing Central Precocious Puberty Exerts Remodeling Effects on the Prefrontal Cortex

et al. 2019

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Central precocious puberty (CPP) has been shown to exert significant effects on psychosocial development. These early puberty-related hormones and psychosocial functional changes are considered to be associated with specific brain development. However, the biological mechanisms underlying the sculpting of human brain architecture and modulation of psychosocial transformation by puberty-related hormonal maturation remain elusive, especially during the early phase of CPP. The current investigation aims to specify the brain regions in which early hormone-related maturation effects occur during CPP and their relationships with psychological functions. 65 young girls (aged 4.3–8.0 years) underwent structural imaging on a 3T MR system, completed psychological tests and performed the gonadotropin-releasing hormone (GnRH) stimulation test to identify hormonal manifestations of hypothalamic–pituitary–gonadal axis (HPG axis) activation. Based on the GnRH test, 28 young girls were identified with CPP, whereas the other 37 girls were identified with non-central precocious puberty (NCPP). Cortical parameters were calculated and compared between the two groups after adjusting for age, weight, and height. Brain regions showing group differences were extracted and correlated with serum hormone levels and psychological parameters. The CPP girls showed thinner cortices primarily in the right rostral middle frontal cortex. This morphological difference was positively correlated with stimulated estradiol (E2) levels. Further, higher E2 levels were significantly associated with higher hyperactivity scores. Premature HPG axis activation in CPP girls at an early stage appears to exert remodeling effects on brain anatomy, primarily in the prefrontal cortex, which may affect psychological development following the emergence of robust changes in sex hormones.

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Allopregnanolone levels decrease after gonadotropin-releasing hormone analog stimulation test in girls with central precocious puberty

Cited by 8 publications

References 37 publications

High diagnostic accuracy of subcutaneous Triptorelin test compared with GnRH test for diagnosing central precocious puberty in girls

High diagnostic accuracy of subcutaneous Triptorelin test compared with GnRH test for diagnosing central precocious puberty in girls

Gray Matter Differences Between Premature Pubertal Girls With and Without the Reactivation of the Hypothalamic—Pituitary-Gonadal Axis

Initiation of the Hypothalamic–Pituitary–Gonadal Axis in Young Girls Undergoing Central Precocious Puberty Exerts Remodeling Effects on the Prefrontal Cortex

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