Alloplant biomaterials as postburn skin scarring inhibitors

Abstract

Allotransplants for eyelid frame plasty by “Alloplant”® may facilitate recovery of eyelid anatomical position and function and prevent postburn scar tissue traction. Purpose of the study. To determine the level of fibrogenic factors after skin burn wound treatment with Alloplant biomaterials in experiment. The tissue level of TGF-β1 and FGF-1 fibrogenic factors was detected immunohistochemically in 84 Wistar rats treated with Alloplant biomaterials for skin burn wounds. It was established that the tissue level of fibrogenic cytokines reduced significantly after treatment with allogenic biomaterials that leads to inhibition of fibroblast proliferation and prevents excessive collagen synthesis. At tissue reparation, allogenic biomaterials inhibit coarse scar formation.

Innervation of Facial Muscles Using an Allogeneic Biomaterial in an Experiment

“…The results of many years of scientific research conducted at the All-Russian Center for Eye and Plastic Surgery (Ufa) showed that, when implanted into the tissues of a living organism, allogeneic biomaterials have the ability to inhibit scarring of various tissues, including muscle [13][14][15]. Used allogeneic biomaterials are gradually resorbed by macrophages and replaced by a newly formed fully differentiated tissue [15][16][17][18][19][20]. Non- specific stimulation of macrophages with allogeneic biomaterial contributes to the restoration of cellular mechanisms for controlling regeneration in tissues that were disturbed during pathology, which leads to reparative processes proceeding on the basis of the laws of physiological regeneration.…”

“…In particular, in the work of A. B. Nuraeva [20], using the factor of reinnervation of mimic muscles during allotransplantation, the possibility of not only anatomical, but also functional restoration of the eyelids was proved.…”