2007
DOI: 10.1159/000100490
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Allogeneic Platelet Gel with Autologous Cancellous Bone Graft for the Treatment of a Large Bone Defect

Abstract: Background/Aims: A 50-year-old type 2 diabetic male with a comminuted fracture of the tibia and delayed union after insufficient initial osteosynthesis with a resulting pseudoarthrosis was treated operatively by using a graft composed of platelet gel mixed with autologous cancellous bone. The essential idea of this therapy was to combine the healing capacities of platelet-derived growth factors and osteogenic stem cells and the modeling capacity of the gel. Due to a history of diabetes, allogeneic instead of a… Show more

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Cited by 51 publications
(41 citation statements)
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“…Therefore new methods, that are patient friendly are being studied. The use of autologous cancellous bone for the treatment of the pseudarthrosis of long bone fractures, together with allogeneic platelets has already been described [3,11]. An addition in our case was the use of heterologous resorbable collagen membrane.…”
Section: Discussionmentioning
confidence: 64%
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“…Therefore new methods, that are patient friendly are being studied. The use of autologous cancellous bone for the treatment of the pseudarthrosis of long bone fractures, together with allogeneic platelets has already been described [3,11]. An addition in our case was the use of heterologous resorbable collagen membrane.…”
Section: Discussionmentioning
confidence: 64%
“…Guided tissue regeneration is well known in oral surgery and is making an entry into orthopaedic trauma surgery [3][4][5]11]. In bone surgery pseudarthrosis and unhealed fractures after osteosynthesis represent a major problem that requires re-surgery.…”
Section: Discussionmentioning
confidence: 99%
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“…The supernatant or releasate of the platelet gel was able to promote dose-dependent proliferation and changes in gene expression as well as in metabolic activities related to protein synthesis (Junger et al, 2000;Valencia et al, 2001;Fang & Galiano, 2008;Bernuzzi et al, 2010;Ficarelli et al, 2008;Chen et al, 2010). The platelet concentrate was used for healing skin, soft tissue wounds, fractures, surgical injuries, diabetic ulcers, dental, oral and maxillofacial settings (Altman et al, 2001;Margolis et al, 2001;Anderson &Baker, 2003;Castro, 2004;Belli et al, 2005;Burkus, 2005;Carreon et al, 2005;Sclafani et al, 2005;Trowbridge et al, 2005;Brown et al, 2006;Driver et al, 2006;Savarino et al, 2006;Rozman & Bolta, 2007;Borzini & Mazzucco 2007;Smrke et al, 2007;Cieslik-Bielecka et al, 2008;).…”
Section: Introductionmentioning
confidence: 99%