Allogeneic parathyroid: 2-year follow-up

Hermosillo-Sandoval, José Manuel; Leonher-Ruezga, Karla Lisseth; Jiménez-Gómez, José Alfredo; González-Ojeda, Alejandro; Ramírez-González, Luis Ricardo

doi:10.1016/j.circen.2015.09.014

Cited by 5 publications

(8 citation statements)

References 11 publications

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“…However, follow‐up results were varied. To our knowledge, only 2 studies have been published which includes long‐term follow‐up . Hermosillo‐Sandoval et al were performed PA for 5 cases.…”

Section: Discussionmentioning

confidence: 99%

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Microencapsulated parathyroid allotransplantation in the omental tissue

et al. 2019

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Permanent hypoparathyroidism is a severe clinical condition accompanied by low parathyroid hormone level. Conventional treatment requires lifelong medication, and daily drug usage has some side effects. To avoid this circumstance, transplantation is an alternative and curative option. Microencapsulation may be used as a transplantation approach particularly to evade immune response. In order to define treatment of permanent hypoparathyroidism, a 37‐year‐old female recipient who has permanent hypoparathyroidism was evaluated for 3 years. Routine tests, viral markers, and T and B lymphocyte cross‐match tests were analyzed. In addition intradermal skin test was performed for ultrapure alginate. Microencapsulation of cultured parathyroid cells was performed with ultrapure alginate. Cell suspension was prepared and spheroids were generated with calcium chloride. Afterward, transplantation was performed with a laparoscopic approach in the omental tissue. The recipient was discharged from the hospital without complications. Serum calcium, parathyroid hormone (PTH), and phosphorus levels were observed throughout 1 year. During the follow‐up period, no complications were observed. Serum calcium levels were increased significantly on day 10 and PTH levels were increased on day 25 as well. According to our knowledge, this is the first study where ultrapure alginate‐based microencapsulated parathyroid cells were transplanted in the omental tissue. A significant increment of PTH levels was detected. Microencapsulated parathyroid cells showed the functionality of this technique for more than 1 year. This study showed that using ultrapure alginate‐based microencapsulation without immunosuppression appears to be a promising technique.

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Section: Discussionmentioning

confidence: 99%

“…Hermosillo‐Sandoval et al were performed PA for 5 cases. One case showed no changes for PTH and the remaining cases were followed up for 2 years with an immunosuppressive regimen . Agha et al performed PA for a 32‐year‐old female; they used 2 healthy parathyroid glands from living donors and transplanted them to the forearm.…”

Section: Discussionmentioning

confidence: 99%

Microencapsulated parathyroid allotransplantation in the omental tissue

et al. 2019

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“…In the last decade, PA studies for both living and cadaver donors have accelerated but long‐term follow‐up has not occurred. To our knowledge, only two studies have been published that include long‐term follow‐up . Hermosillo‐Sandoval et al .…”

Section: Discussionmentioning

confidence: 99%

“…To our knowledge, only two studies have been published that include long‐term follow‐up . Hermosillo‐Sandoval et al . performed PA for five cases.…”

Section: Discussionmentioning

confidence: 99%

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Fresh tissue parathyroid allotransplantation with short‐term immunosuppression: 1‐year follow‐up

Yücesan

Göncü

Başoğlu

et al. 2017

Clinical Transplantation

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Living-donor parathyroid allotransplantation for therapy-refractory postsurgical persistent hypoparathyroidism in a nontransplant recipient – three year results: a case report

et al. 2016

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BackgroundTherapy-refractory persistent hypoparathyroidism after extensive neck surgery is a rare but severe complication. Parathyroid allotransplantation may represent a definitive treatment option.Case presentationA 32-year old female was referred to our hospital with intractable persistent hypocalcemia after neck surgery for papillary thyroid cancer. Despite optimal medical treatment including calcium and vitamin D supplementation and even hormonal replacement therapy hypocalcemic symptoms failed to improve. The quality of life was considered very low. In light of the unsuccessful medical therapy and the young age of the patient parathyroid allotransplantation seemed an attractive treatment option to restore normal calcium homeostasis despite of the need for immunosuppressive therapy after the procedure. Therefore, we performed living-donor allotransplantation of two healthy parathyroid glands to the recipient’s left forearm. The surgical intervention was successful. Neither the donor nor the recipient showed any complications. In the postoperative course clinical symptoms of hypocalcemia significantly improved whereas serum calcium and parathyroid hormone (PTH) levels progressively increased into the normal range. Former intense replacement therapy could be discontinued completely in a stepwise fashion. To date, nearly three years after transplantation, the patient remains asymptomatic with normal serum levels of calcium and PTH.ConclusionSuccessful living-donor parathyroid allotransplantation for postsurgical hypoparathyroidism represents an innovative therapeutic strategy that could provide the definitive treatment in those patients in which the disease is therapy-refractory. The procedure can be justified even in nontransplant recipients. Retrieval of parathyroid glands from healthy donors is feasible and safe.

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Allogeneic parathyroid: 2-year follow-up

Cited by 5 publications

References 11 publications

Microencapsulated parathyroid allotransplantation in the omental tissue

Microencapsulated parathyroid allotransplantation in the omental tissue

Fresh tissue parathyroid allotransplantation with short‐term immunosuppression: 1‐year follow‐up

Living-donor parathyroid allotransplantation for therapy-refractory postsurgical persistent hypoparathyroidism in a nontransplant recipient – three year results: a case report

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