Fresh tissue parathyroid allotransplantation with short‐term immunosuppression: 1‐year follow‐up

Abstract

Fresh tissue PA with short-term immunosuppression appears to be a promising technique that is easy to perform, is cost-effective, has low risk of side effects and minimal complications with compatibility for HLA conditions. A longer follow-up period and more case studies are needed to determine the risks and benefits of this procedure for future cases.

Periferik kan mononükleer hücrelerin primer paratiroit dokusu hücreleri ile ko-kültürünün verimliliği

“…Paratiroit nakli ile ilgili literatürdeki immünolojik kriterler halen standardize edilmemiştir. Fakat her nakil birimi kendi kriterler ve takip parametrelerini belirleme konu-sunda karar alma yetkisine sahiptir (7). Bununla birlikte, lenfosit CXM ve mikrolenfositotoksisite gibi testler için hem alıcı hem de donörün aynı anda kan vermesi gerekmektedir.…”

“…KH tedavisinde D vitamini ve oral kalsiyum takviyesi standart semptomatik tedavi yöntemleridir. Fakat bu takviyelerin uzun süre kullanılmasının, hastanın üzerinde birçok yan etkisi vardır (7). Paratiroit allotransplantasyonu (PA) ise alternatif ve hastalığı tedavi edici tek yöntem olarak görülmektedir (8) hücre izole edilmiştir.…”

MANAGEMENT OF ENDOCRINE DISEASE: Postsurgical hypoparathyroidism: current treatments and future prospects for parathyroid allotransplantation

“…The commonly used method is injection into the left deltoid muscles ( 41 ) and forearm muscles ( 27 ), but some centres used laparoscopic transplantation in the omental tissue ( 37 ). In animal models, the thymus ( 42 ) and the adrenal glands ( 43 ) appear to be a privileged sites for PTalloT, but these experimental data would have limited clinical applicability.…”

“…In a more recent report, the parathyroid glands resected from the living donors with secondary hyperparathyroidism were fragmented quickly in the operation room before being injected into the left deltoid muscles of the two recipients ( 41 ).…”

Fresh Tissue Parathyroid Allotransplantation from a Cadaveric Donor without Immunosuppression: A 3-Year Follow-Up

“…PA can play an important role in the treatment of PH. 7,[10][11][12] Much of the literature on PA consists of case reports, rather than clinical series, with no longterm follow-up. 5-7, 9, 12, 13 The fresh-tissue PA technique has been used for a long time.…”