Allodynia in Cluster Headache

Ashkenazi, Avi

doi:10.1007/s11916-010-0097-7

Cited by 16 publications

(8 citation statements)

References 23 publications

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“…Current theories attribute to central sensitization an important role in tension type headache pathogenesis [ 36 - 38 ] with evidence of allodynia symptoms in chronic forms [ 38 ], as confirmed by present results. In regard to cluster headache, previous studies reported allodynia during cluster episodes, in accord with present results [ 39 ], while this is the first study suggesting the presence of allodynia in other TACs, as paroxysmal migraine and hemicranias continua. Actually we cannot advance conclusions on reduced expression of allodynia in the mixed headaches group, which was a very heterogeneous group and worthy of further case series enlargement, considering the importance of a better knowledge of these rare disorders.…”

Section: Discussionsupporting

confidence: 92%

Sleep features and central sensitization symptoms in primary headache patients

et al. 2014

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BackgroundAssociation between sleep disorders and headache is largely known. The aim of the present study was to evaluate sleep quality and quantity in a large cohort of primary headache patients, in order to correlate these scores with symptoms of central sensitization as allodynia, pericranial tenderness and comorbidity with diffuse muscle-skeletal pain.MethodsOne thousand six hundreds and seventy primary headache out patients were submitted to the Medical Outcomes Study (MOS) within a clinical assessment, consisting of evaluation of frequency of headache, pericranial tenderness, allodynia and coexistence of fibromyalgia syndrome (FM).ResultsTen groups of primary headache patients were individuated, including patients with episodic and chronic migraine and tension type headache, mixed forms, cluster headache and other trigeminal autonomic cephalalgias. Duration but not sleep disturbances score was correlated with symptoms of central sensitization as allodynia and pericranial tenderness in primary headache patients. The association among allodynia, pericranial tenderness and short sleep characterized chronic migraine more than any other primary headache form. Patients presenting with FM comorbidity suffered from sleep disturbances in addition to reduction of sleep duration.ConclusionSelf reported duration of sleep seems a useful index to be correlated with allodynia, pericranial tenderness and chronic headache as a therapeutic target to be assessed in forthcoming studies aiming to prevent central sensitization symptoms development.

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Section: Discussionsupporting

confidence: 92%

Sleep features and central sensitization symptoms in primary headache patients

et al. 2014

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“…Given the presence of allodynia in other primary headache disorders, these data may also have implications for conditions such as cluster and tension-type headache [2; 8]. Our findings show that the primed state can develop following a single exposure of the dura to IL-6 or a single injection of i.c.…”

Section: Discussionmentioning

confidence: 62%

Dural stimulation in rats causes brain-derived neurotrophic factor–dependent priming to subthreshold stimuli including a migraine trigger

Burgos-Vega

Quigley

Avona

et al. 2016

PAIN

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Migraine is one of the most common and most disabling disorders. Between attacks, migraine patients are otherwise normal but are sensitized to non-noxious events known as triggers. The purpose of these studies was to investigate whether a headache-like event causes sensitization, or priming, to subsequent subthreshold events. Interleukin-6 (IL-6) was applied to the rat cranial dura mater which produced cutaneous facial and hindpaw allodynia that lasted 24 hours. At 72-hours, IL-6 treated rats developed allodynia in response to dural stimulation with either a pH 6.8 or pH 7.0 solution and to a systemic nitric oxide (NO) donor, a well-known migraine trigger. Vehicle-treated rats did not respond to either pH stimulus nor to the NO donor, demonstrating that IL-6 exposure primes rats to subthreshold stimuli. Inhibitors of brain-derived neurotrophic factor (BDNF) signaling given either systemically or intracisternally 24-hours after IL-6 eliminated responses to dural pH stimulation at 72 hours. Additionally, intracisternal administration of BDNF without prior dural stimulation produced allodynia and once resolved, animals were primed to dural pH 6.8/pH 7.0 and a systemic NO donor. Finally, hindpaw IL-6 produced paw allodynia but not priming to paw injection of pH 7.0 at 72 hours demonstrating differences in priming depending on location. These data indicate that afferent input from the meninges produces BDNF-dependent priming of the dural nociceptive system. This primed state mimics the interictal period of migraine where attacks can be triggered by normally non-noxious events and suggests that BDNF-dependent plasticity may contribute to migraine.

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“…Both the extent to which the mechanisms of allodynia are shared across different headache syndromes and the identity of the specific aspects that may be syndrome-specific remain unknown. However, a previous study has suggested that the presence of allodynia not only contributes to our understanding of the pathophysiological mechanism of CH but may also be helpful in determining the treatment and predicting the therapeutic response ( 40 ). In our study, there was no significant difference in the presence of or scores for cutaneous allodynia between those with probable CH and those with definite CH.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features of Probable Cluster Headache: A Prospective, Cross-Sectional Multicenter Study

et al. 2018

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Background: Epidemiological data of probable cluster headaches (CH) are scarce in the relevant literature. Here, we sought to assess the prevalence and clinical characteristics of probable CH in comparison with definite CH.Methods: Data used in this study were obtained from the Korean Cluster Headache Registry (KCHR), a prospective, cross-sectional, multicenter headache registry that collected data from consecutive patients diagnosed with CH.Results: In total, 159 patients were enrolled in this study; 20 (12.6%) were diagnosed with probable CH. The most common unfulfilled criterion in patients with probable CH was the duration of attack, which was found in 40% of patients with probable CH. Among clinical characteristics, the number of autonomic symptoms tended to be lower in probable CH than in definite CH (1.7 ± 1.2 vs. 2.4 ± 1.5, p = 0.051) and conjunctival injection and lacrimation showed an increased odds ratio (OR) [OR = 3.03; 95% confidence interval (CI): 1.03–8.33] in definite CH. The groups did not differ with regard to baseline demographic characteristics, disability, impact on life, or treatment response.Conclusions: Probable CH is relatively common among CH disorders, with a clinical impact similar to that of definite CH.

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Allodynia in Cluster Headache

Cited by 16 publications

References 23 publications

Sleep features and central sensitization symptoms in primary headache patients

Sleep features and central sensitization symptoms in primary headache patients

Dural stimulation in rats causes brain-derived neurotrophic factor–dependent priming to subthreshold stimuli including a migraine trigger

Clinical Features of Probable Cluster Headache: A Prospective, Cross-Sectional Multicenter Study

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