Clinical Features of Probable Cluster Headache: A Prospective, Cross-Sectional Multicenter Study

Sohn, Jong Hee; Choi, Yun Ju; Kim, Byung-Kun; Chung, Pil-Wook; Lee, Mi Ji; Chu, Min Kyung; Ahn, Jin Young; Kim, Byung Su; Song, Tae Jin; Oh, Kyungmi; Lee, Kwang Soo; Kim, Sang-Yong; Park, Kwang‐Yeol; Chung, Jae Myun; Moon, Heui Soo; Chung, Chin Sang; Cho, Soo-Jin; Park, Jeong Wook

doi:10.3389/fneur.2018.00908

Cited by 19 publications

(23 citation statements)

References 42 publications

(46 reference statements)

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“…There are no published placebo-controlled trials on CH treatment in Asian countries. Regarding acute treatment, the response rate to triptan ranges in Asian studies from 80.0–97.3% ( 9 , 14 , 37 , 41 ), and high-flow oxygen works for 71.0–85.7% of the patients ( 9 , 14 , 41 ). One Korean study reported a 100% response rate to high-flow oxygen in CH patients with cutaneous allodynia vs. 50% in those without ( p = 0.07), but the case number was small ( 37 ).…”

Section: Resultsmentioning

confidence: 99%

“…Considering chronic prevention, only a limited number of studies on treatment responses in Asian regions exist. In one study, prednisolone was effective as a transition therapy in 84% of patients (9), whereas verapamil was proven effective in 74-93% of the patients in various studies (9,14,41). One study in Taiwan showed a dose-dependent response to verapamil as a cluster headache prophylactic treatment.…”

Section: Treatment Response Of Cluster Headache In Asian Countriesmentioning

confidence: 99%

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Cluster headache in Asian populations: Similarities, disparities, and a narrative review of the mechanisms of the chronic subtype

2020

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Objective Headache disorders like migraine show geographic and ethnic differences between Asian and European/North American countries. In cluster headache, these differences are rarely mentioned and discussed. This article aimed to review the characteristics of cluster headache in Asian countries and compare the clinical features to those in European and North American populations. Methods We conducted a narrative literature review on the demographics, clinical presentations, and treatments of cluster headache in Asian countries. Results Patients with cluster headache in Asian populations showed a stronger male predominance compared to European and North American populations. Chronic cluster headache was rare in Asian countries. The clinical presentation of restlessness was not as common in Asian as it was in European and North American countries, and Asian patients with aura were extremely rare. Patients in Asian countries may have a lower circadian rhythmicity of cluster headache and a lower headache load, as demonstrated by lower attack frequencies per day, bout frequencies, and bout durations. Conclusions Regional differences in the presentation of cluster headache exist. Greater awareness for cluster headache should be raised in Asian regions, and further studies are warranted to elucidate the mechanisms behind observed differences.

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Section: Resultsmentioning

confidence: 99%

Section: Treatment Response Of Cluster Headache In Asian Countriesmentioning

confidence: 99%

Cluster headache in Asian populations: Similarities, disparities, and a narrative review of the mechanisms of the chronic subtype

2020

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“…The details of the KCHR study are published in our previous studies (11–13). In brief, the KCHR study comprises several sub-studies, including this study.…”

Section: Methodsmentioning

confidence: 99%

Temporal changes of circadian rhythmicity in cluster headache

et al. 2019

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Objective To investigate the temporal changes of circadian rhythmicity in relation to the disease course in patients with cluster headache. Methods In this multicenter study, patients with cluster headache were recruited between September 2016 and July 2018. We evaluated the patients for circadian rhythmicity and time of cluster headache attacks in the current bout and any experience of bout-to-bout change in circadian rhythmicity. We analyzed the patterns of circadian rhythmicity in relation to the disease progression (the number of total lifetime bouts, grouped into deciles). Results Of the 175 patients in their active, within-bout period, 86 (49.1%) had circadian rhythmicity in the current bout. The prevalence of circadian rhythmicity in the active period was overall similar regardless of disease progression. Sixty-three (46.3%) out of 136 patients with ≥2 bouts reported bout-to-bout changes in circadian rhythmicity. The most frequent time of cluster headache attacks was distributed evenly throughout the day earlier in the disease course and dichotomized into hypnic and midday as the number of lifetime bouts increased ( p = 0.037 for the homogeneity of variance). When grouped into nighttime and daytime, nighttime attacks were predominant early in the disease course, while daytime attacks increased with disease progression (up to 7th deciles of total lifetime bouts, p = 0.001) and decreased in patients with the most advanced disease course ( p = 0.013 for the non-linear association). Conclusions Circadian rhythmicity is not a fixed factor, and changes according to the disease course. Our findings will be valuable in providing a new insight into the stability of functional involvement of the suprachiasmatic nucleus in the pathophysiology of cluster headache.

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“…Comorbid migraine was also determined based on the ICHD-3. The detailed protocol of the KCHR has been published elsewhere previously [24][25][26]. The study protocol was approved by the IRB in each study hospital and complied with the Declaration of Helsinki and Good Clinical Practice guidelines.…”

Section: Participants and Study Designmentioning

confidence: 99%

The impact of remission and coexisting migraine on anxiety and depression in cluster headache

et al. 2020

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Background: Our aim was to investigate the relationship between coexisting cluster headache (CH) and migraine with anxiety and depression during active cluster bouts, and how symptoms change during remission. Methods: We analyzed data from 222 consecutive CH patients and 99 age-and sex-matched controls using a prospective multicenter registry. Anxiety or depression was evaluated using the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9), respectively. Moderate-to-severe anxiety or depression was defined as a score of ≥10 at baseline (during a cluster bout). We assessed for changes in anxiety and depression during CH remission periods. Results: Among the CH patients, the prevalence of moderate-to-severe anxiety and depression was seen in 38.2% and 34.6%, respectively. Compared with controls, CH patients were associated with moderate-to-severe anxiety and depression (multivariable-adjusted odds ratio [aOR] = 7.32, 95% confidence intervals [CI] = 3.35-15.99 and aOR = 4.95, 95% CI = 2.32-10.57, respectively). CH patients with migraine were significantly more likely to have moderate-tosevere anxiety and depression (aOR = 32.53, 95% CI = 6.63-159.64 and aOR = 16.88, 95% CI = 4.16-68.38, respectively), compared to controls without migraine. The GAD-7 and PHQ-9 scores were significantly reduced between cluster bout and remission periods (from 6.8 ± 5.6 to 1.6 ± 2.8; P < 0.001, and from 6.1 ± 5.0 to 1.8 ± 2.4; P < 0.001, respectively). Conclusions: Our results indicate that CH patients are at increased risk of anxiety and depression, especially in the presence of coexisting migraine. However, the anxiety and depression can improve during remission periods.

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Clinical Features of Probable Cluster Headache: A Prospective, Cross-Sectional Multicenter Study

Cited by 19 publications

References 42 publications

Cluster headache in Asian populations: Similarities, disparities, and a narrative review of the mechanisms of the chronic subtype

Cluster headache in Asian populations: Similarities, disparities, and a narrative review of the mechanisms of the chronic subtype

Temporal changes of circadian rhythmicity in cluster headache

The impact of remission and coexisting migraine on anxiety and depression in cluster headache

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