Allo-Aggression in Chickens: Analysis of the B-Complex by Means of GVH Splenomegaly and by Inhibitory Antibodies

Simonsen, Morten; Hála, K; Vilhelmová, M

doi:10.1007/978-1-4613-4169-7_25

Cited by 11 publications

(3 citation statements)

References 6 publications

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“…The B-F region regulates graft rejection [38] and GVHR [80], the latter being blocked by anti-F antisera [77]. Using the congenic lines CB and CC and recombinant haplotypes B'^i and B^2^ (^jg j-egion was also found to regulate regression of RSV-induced tumours [35].…”

Section: Function Of the Mhcmentioning

confidence: 99%

Chicken Major Histocompatibility Complex and Disease

Hála¹,

Boyd²,

Wick³

1981

Scand J Immunol

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The chicken MHC (B complex) initially described by Briles as controlling blood antigens, is now known to be composed of at least three regions, L, F and G. Two of these, F and G, were described on the basis of recombinants found in a study of over 10,000 chickens. On the basis of biochemical, tissue distribution and functional analyses, F corresponds to the murine H-2 K/D regions. The G region is unique to the chicken since the antigenic product is expressed only on erythrocytes and their progenitors. L was identified by serological studies and corresponds to the H-2 I region; the L antigen is expressed predominantly on B lymphocytes, monocytes and 10% of T lymphocytes, and differences in the L region result in variations in immune responsiveness. A number of functional similarities exist between the chicken MHC and that of other species such as regulation of graft rejection, graft-versus-host reaction (GVHR) and mixed lymphocyte reactions (MLR), mitogenic and immune responsiveness and resistance to RNA and DNA virus infection. The chicken MHC also controls the severity of autoimmune disease, as exemplified by the spontaneous thyroiditis of Obese strain (OS) chickens. It differs from mammalian MHC's by having of lower crossing-over frequency and no apparent gene duplication.

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Section: Function Of the Mhcmentioning

confidence: 99%

Chicken Major Histocompatibility Complex and Disease

Hála¹,

Boyd²,

Wick³

1981

Scand J Immunol

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“…Control of MLR was demonstrated by Miggiano et al [26] and Schou [31]. The controlling genes have been mapped to the region encoding B-L and B-F antigens [35,37].…”

Section: Involvement Of B-l In Mixed Lymphocyte Reactions and Graft-vmentioning

confidence: 96%

B‐L Antigens (Ia‐like Antigens) of the Chicken Major Histocompatibility Complex

1981

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This paper reviews the present knowledge of B-L antigens encoded by the chicken B complex as regards to the following aspects: (1) identification and cellular expression, (2) structural studies, (3) evidence for two distinct populations of B-L antigens, (4) mapping of B-L loci of the B complex, (5) B-L and immune response, and (6) the role of the B-L antigens for the control of mixed lymphocyte reactions (MLR) and graft-versus-host (GVH) reactions. It is concluded that B-L antigens of the chicken exhibit extensive homology with mammalian Ia antigens. A genetic map of the B complex is presented.

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“…G VH-inhibition-release (G VH-I-R) test: An anti F13 serum diluted 1:lOO in PBS was absorbed twice for 20-30 minutes at room temperature with half a volume o f packed, washed blood cells from the individual outbred chickens. These absorbed serum samples were then tested for inhibition of the GVH splenomegaly produced by inbred G-Bl cells in outbred eggs (Simonsen 1975, Simonsen et al 1977a. A complete removal of inhibitory activity indicates the presence of the F13 phenotype in the cells used for absorption.…”

Section: Anti-l Alloantisera and L Typingmentioning

confidence: 99%

The major histocoinpatibility complex of outbred chickens: I. Analysis of the B¹³ haplotype by serology and cellular reactions

1982

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The F antigens, which are serologically defined Class I gene products of the major histocompatibility complex in chickens (the B complex), were analysed in outbred birds. Private specificities of the F13 antigen from the inbred CC strain were detected in 20 outbred chickens by a haemagglutination technique. In the GVH-inhibition-release test F13 antigens from outbred and inbred chickens were identical.The L antigens, which are the Class I1 antigens of the B complex, were detected with specific anti L13 alloantisera by indirect immunofluorescence. Antisera defining the L13 antigen(s) of the inbred C C line reacted with all F13 positive outbreds. As a test of one-way direct compatibility of the inbred and outbred animals typing F13, graft versus host reactions were performed, injecting blood of F13 positive outbreds into inbred B'3''3 cggs. N o GVH stimulation attributable to MHC determinants was found. In MLR, responder cells from outbred M H C heterozygous chickens, which typed F13/x, were stimulated by inbred F13113 homozygous typing cells, and weak, but significant, reactions were found. Further analysis in the accompanying paper, however, revealed no difference in the lymphocyte activating determinants (Lads) of inbred and outbred birds typing F13 and L13. No individual has yet been found which carries one of these antigens in the absence of the other.List of abbreviations: B = The complex of linked genes constituting the @ 1982 Munksgaard, Copenhagen

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Allo-Aggression in Chickens: Analysis of the B-Complex by Means of GVH Splenomegaly and by Inhibitory Antibodies

Cited by 11 publications

References 6 publications

Chicken Major Histocompatibility Complex and Disease

Chicken Major Histocompatibility Complex and Disease

B‐L Antigens (Ia‐like Antigens) of the Chicken Major Histocompatibility Complex

The major histocoinpatibility complex of outbred chickens: I. Analysis of the B¹³ haplotype by serology and cellular reactions

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Allo-Aggression in Chickens: Analysis of the B-Complex by Means of GVH Splenomegaly and by Inhibitory Antibodies

Cited by 11 publications

References 6 publications

Chicken Major Histocompatibility Complex and Disease

Chicken Major Histocompatibility Complex and Disease

B‐L Antigens (Ia‐like Antigens) of the Chicken Major Histocompatibility Complex

The major histocoinpatibility complex of outbred chickens: I. Analysis of the B13 haplotype by serology and cellular reactions

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The major histocoinpatibility complex of outbred chickens: I. Analysis of the B¹³ haplotype by serology and cellular reactions