Allium hirtifolium protects Cyprinus carpio against the detrimental responses mediated by foodborne zinc oxide nanoparticle

Rashidian, Ghasem; Mahboub, Heba H.; Hoseinifar, Seyed Hossein; Ghafarifarsani, Hamed; Zare, Mahyar; Punyatong, Montri; Doan, Hein Van

doi:10.1016/j.aquaculture.2022.738252

Cited by 14 publications

(5 citation statements)

References 54 publications

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“…Herein, the whole-body composition revealed a reduction in the lipid content compared with the control and other groups. Similar to our findings, Rashidian et al recorded reduced growth performance in Cyprinus carpio exposed to ZnO-NPs [ 38 ]. Furthermore, ZnO-NPs were reported to inhibit zebrafish’s normal development and growth affecting the expression of cell cycle-related genes [ 81 ].…”

Section: Discussionsupporting

confidence: 92%

“…In agreement with our findings, Brun et al reported that ZnO-NPs produced transcriptional changes in pro-inflammatory cytokines TNF-α and IL-1β in zebrafish embryos [ 37 ]. Similarly, Rashidian et al demonstrated that ZnO-NPs upregulated Il-1β, TNF-α, and IL-8 in Cyprinus carpio exposed to ZnO-NPs [ 38 ]. Additionally, Tan et al reported that the ultrafine particulate matter can activate Kupffer cells in animal models and thus exacerbate non-alcoholic fatty liver disease (NAFLD) [ 93 ].…”

Section: Discussionmentioning

confidence: 99%

“…In the same context, embryos of zebrafish exposed to ZnO-NPs exhibited transcriptional modulations of pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β) [ 37 ]. In addition, ZnO-NPs upregulated the expression of IL-1β, TNF-α, and interleukin-8 (IL-8) in the intestine of Cyprinus carpio [ 38 ].…”

Section: Introductionmentioning

confidence: 99%

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Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish

Mawed

Centoducati

Farag

et al. 2022

Biology

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Microalgae are rich in bioactive compounds including pigments, proteins, lipids, polyunsaturated fatty acids, carbohydrates, and vitamins. Due to their non-toxic and nutritious characteristics, these are suggested as important food for many aquatic animals. Dunaliella salina is a well-known microalga that accumulates valuable amounts of carotenoids. We investigated whether it could restore the metabolic equilibrium and mitigate the hepatic inflammation induced by zinc oxide nanoparticles (ZnO-NPs) using male zebrafish which were exposed to 1/5th 96 h-LC50 for 4 weeks, followed by dietary supplementation with D. salina at two concentrations (15% and 30%) for 2 weeks. Collectively, ZnO-NPs affected fish appetite, whole body composition, hepatic glycogen and lipid contents, intestinal bacterial and Aeromonas counts, as well as hepatic tumor necrosis factor- α (TNF-α). In addition, the mRNA expression of genes related to gluconeogenesis (pck1, gys2, and g6pc3), lipogenesis (srepf1, acaca, fasn, and cd36), and inflammatory response (tnf-α, tnf-β, nf-kb2) were modulated. D. salina reduced the body burden of zinc residues, restored the fish appetite and normal liver architecture, and mitigated the toxic impacts of ZnO-NPs on whole-body composition, intestinal bacteria, energy metabolism, and hepatic inflammatory markers. Our results revealed that the administration of D. salina might be effective in neutralizing the hepatotoxic effects of ZnO-NPs in the zebrafish model.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish

Mawed

Centoducati

Farag

et al. 2022

Biology

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“…To avoid the resistance of the pathogen to antibiotics [ 4 ], plants are a non-antibiotic, safe, and cheap source that exhibits potent antibacterial activity in aquaculture [ 5 , 6 , 7 , 8 ]. Another significant reason for utilizing plant extracts is their natural multi-constituents that are well-documented and verified for promising fish growth and immune-antioxidant traits [ 9 , 10 , 11 ]. In addition, they protect farmed fish exposed to biotic and abiotic stressors [ 12 ], which negatively affect the performance of fish [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Physiological Performance, Antioxidant and Immune Status, Columnaris Resistance, and Growth of Nile Tilapia That Received Alchemilla vulgaris-Supplemented Diets

et al. 2022

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The current perspective is a pioneering trial to assess the efficacy of the dietary supplementation of Alchemilla vulgaris powder (AVP) in the diet of Nile tilapia (Oreochromis niloticus) on growth performance, blood picture, hepatic and renal biomarkers, immune status, and serum and tissue antioxidant capacity and to investigate the resistance against Flavobacterium columnare challenge. Fish (n = 360) were distributed into six groups (three replicates each) and received increasing AVP supplementation levels (0, 2, 4, 6, 8, and 10 g kg−1) for 60 days. Furthermore, fish were exposed to the bacterial challenge of a virulent F. columnare strain and maintained under observation for 12 days. During the observation period, clinical signs and the cumulative mortality percentage were recorded. The results demonstrated that the growth performance, feed conversion ratio, and hematological profile were noticeably enhanced in the AVP-supplemented groups compared to the control. The most promising results of weight gain and feed conversion ratio were recorded in the groups with 6, 8, and 10 g AVP kg−1 diets in a linear regression trend. The levels of hepatorenal function indicators were maintained in a healthy range in the different dietary AVP-supplemented groups. In a dose-dependent manner, fish fed AVP dietary supplements displayed significant augmented serum levels of innate immune indicators (lysozyme, nitric oxide, and complement 3) and antioxidant biomarkers (Catalase (CAT), superoxide dismutase (SOD), total antioxidant (TAC), and reduced glutathione (GSH) with a marked decrease in myeloperoxidase (MPO) and malondialdehyde (MDA) levels). Likewise, hepatic CAT and SOD activities were significantly improved, and the opposite trend was recorded with hepatic MDA. The highest AVP-supplemented dose (10 g/kg) recorded the highest immune-antioxidant status. Based on the study findings, we highlight the efficacy of AVP as a nutraceutical dietary supplementation for aquaculture to enhance growth, physiological performance, and immune-antioxidant status and as a natural economic antibacterial agent in O. niloticus for sustaining aquaculture. It could be concluded that the dietary supplementation of 10 g AVP/kg enhanced O. niloticus growth, physiological performance, immune-antioxidant status, and resistance against F. columnare.

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“…The major sources for the entrance of NPs into the aquatic environment include unintentional sources, anthropogenic sources, and the usage of engineered nanoparticles causing adverse effects on all aquatic organisms [12]. The toxicity by ZnO-NPs can induce bioaccumulation in fish tissues, oxidative stress, and sub-acute toxicity in Cyprinus carpio [13][14][15][16]. Moreover, they induce oxidative damage in zebrafish and O. niloticus [17,18], and hepatic and gill damage in Oreochromis mossambicus [19].…”

Section: Introductionmentioning

confidence: 99%

Effect of Dietary Moringa oleifera Leaves Nanoparticles on Growth Performance, Physiological, Immunological Responses, and Liver Antioxidant Biomarkers in Nile tilapia (Oreochromis niloticus) against Zinc Oxide Nanoparticles Toxicity

Hamed

Amen

El-Elemi

et al. 2022

Fishes

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The current study addresses the influence of Moringa oleifera leaves nanoparticles (MO-NPs) on growth, biochemical, immunological, and hepatic antioxidant alterations induced by zinc oxide nanoparticles toxicity in Nile tilapia (O. niloticus). Fish (N = 180) were divided into four groups with replicates. The first one was set as a control group and the second group was fed an MO-NPs-enriched diet (2.5 g/kg diet). The third group was exposed to 8 mg/L ZnO-NPs, while the forth group was exposed to 8 mg/L ZnO-NPs and fed on MO-NPs (2.5 g/kg diet) for 2 months. Exposure of O. niloticus to 8 mg/L ZnO-NPs induced the following consequences: a sharp decrease in the growth parameters; a marked increment in the biochemical biomarkers (glucose, cortisol, and liver enzymes (ALT, AST, ALP); a significant increase in serum renal products, urea and creatinine, cholesterol, and LDH levels. Nonetheless, the dietary MO-NPs supplementation for 2 months significantly alleviated the ZnO-NPs toxicity and significantly enhanced the growth indices, plus normalizing the physio-biochemical levels in the exposed group to ZnO-NPs toxicity to reach the levels of the control group. The MO-NPs markedly improved hepatic antioxidant biomarkers, MDA, and TAC, while, decreasing SOD, CAT, and GSH levels to be near the control values. Moreover, supplemented fish in MO-NPs (2.5 g/kg diet) and exposed to ZnO-NPs provided a remarkable increase in the immune profile (respiratory burst (RB) activity, lysozyme, and total immunoglobulins (IgM)) compared to the ZnO-NPs-intoxicated group. Based on the findings of the study, the exposed O. niloticus to ZnO-NPs were immune-antioxidant-depressed, besides showing growth retardation, and physio-biochemical alterations. On the other hand, a supplemented diet with MO-NPs is a novel approach to ameliorate ZnO-NPs toxicity for sustaining aquaculture and correspondingly protecting human health.

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Allium hirtifolium protects Cyprinus carpio against the detrimental responses mediated by foodborne zinc oxide nanoparticle

Cited by 14 publications

References 54 publications

Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish

Dunaliella salina Microalga Restores the Metabolic Equilibrium and Ameliorates the Hepatic Inflammatory Response Induced by Zinc Oxide Nanoparticles (ZnO-NPs) in Male Zebrafish

Physiological Performance, Antioxidant and Immune Status, Columnaris Resistance, and Growth of Nile Tilapia That Received Alchemilla vulgaris-Supplemented Diets

Effect of Dietary Moringa oleifera Leaves Nanoparticles on Growth Performance, Physiological, Immunological Responses, and Liver Antioxidant Biomarkers in Nile tilapia (Oreochromis niloticus) against Zinc Oxide Nanoparticles Toxicity

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