Allitol: production, properties and applications

Abstract

Summary Allitol is a rare alcohol monosaccharide sweetener containing six carbons atoms. It is a major product of the d‐psicose reduction pathway that exerts various physiological effects, for example laxative effects for the treatment of constipation and anti‐obesity effects by suppressing lipid accumulation. Allitol can be also used as an anticrystallisation agent. In addition, allitol cross‐links d‐ and l‐hexoses, thus contributing to production of l‐psicose. This is a review of the recent studies on the sources, properties, physiological functions and applications of allitol. In addition, the biochemical properties of ribitol dehydrogenase enzymes and the biotechnological production of allitol via microbial and enzymatic synthesis from d‐psicose and directly from d‐fructose are reviewed.

Dietary Dried Sweetspire (<i>Itea</i>) Powder Reduces Body Fat Accumulation in Rats Fed with a High-fat Diet

“…Thus, our present findings may be due to the effect of allitol contained in SP with D-allulose or the synergistic effect of D-allulose and allitol. Allitol is a rare alcohol monosaccharide containing six carbon atoms 17) . It is a major product of the D-allulose reduction pathway.…”

Reconstruction of a Cofactor Self-Sufficient Whole-Cell Biocatalyst System for Efficient Biosynthesis of Allitol from d-Glucose

“…Investigations on the biological synthesis of allitol mediated by microbial whole-cell biocatalysis are still in their infancy. Most previous studies focused on mining the new sources of enzymes in individual modules and the basic cell factory constructions . For example, Klebsiella oxytoca has been isolated, and recombinant Escherichia coli coexpressing ribitol dehydrogenase (RDH) and formate dehydrogenase (FDH) has been constructed to produce allitol from d -allulose at a high conversion rate but at high production costs. , The following construction of an in vivo multienzyme cascade catalysis system (MECCS) containing d -psicose 3-epimerase (DPEase), RDH, and FDH in engineered strains also facilitated the production of allitol from d -fructose, or from glucose isomerase (GI)-pretreated d -glucose, to decrease the production costs .…”

D-Allulose (D-Psicose) Biotransformation From Allitol by a Newly Found NAD(P)-Dependent Alcohol Dehydrogenase From Gluconobacter frateurii NBRC 3264 and the Enzyme Characterization

“…Fortunately, D -allulose can also be biotransformed from allitol by using dehydrogenation reaction using dehydrogenase as the catalyst according to the Izumoring strategy ( Izumori, 2006 ), which can overcome the above limitation of the thermodynamic equilibrium and improve the conversion rate of D -allulose. Moreover, allitol can be prepared easily from low-cost substrates of D -glucose or D -fructose by the biotransformation method ( Zhu et al, 2015 ; Hassanin et al, 2016 ; Wen et al, 2020a , b ). Poonperm et al (2007) biotransformed allitol into D -allulose by using the resting cells of Bacillus pallidus Y25 for the first time.…”