Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice

Gao, Wenqi; Wang, Wei; Zhang, Jing; Deng, Pengyi; Hu, Jun; Yang, Jian; Deng, Zhifang

doi:10.1007/s11011-019-00443-y

Cited by 35 publications

(23 citation statements)

References 68 publications

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“…Bioactive compounds in food have attracted much attention as a safe and effective molecular library. It has been reported that garlic is an excellent natural source of bioactive compounds (Gao et al, 2019). In this study, we revealed the beneficial effects of allicin on energy homeostasis in obese mice.…”

Section: Discussionmentioning

confidence: 55%

Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

Zhang

Sheng

et al. 2020

iScience

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Section: Discussionmentioning

confidence: 55%

Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

Zhang

Sheng

et al. 2020

iScience

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“…Allicin (thio-2-propene-1-sulfinic acid S-allyl ester) is the principal component of garlic and has many physiological functions. Several studies have reported that garlic or its main ingredient, allicin, has an anti-obesity, anti-hyperinsulinemic, anti-hyperlipidemic, and anti-hypertensive effect ( 23, 29–31 ). Among them, a research article reported that Allicin could induce brown-like adipogenesis and increased lipid oxidation in subcutaneous fat though KLF15 signal cascade ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Allicin regulates energy homeostasis through brown adipose tissue

Zhang

Sheng

et al. 2019

Preprint

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AbstractBackground/objectives:Disorder of energy homeostasis can lead to a variety of metabolic diseases, especially obesity. Brown adipose tissue (BAT) is a promising potential therapeutic target for the treatment of obesity and related metabolic diseases. Allicin, a main bioactive ingredient in garlic, has multiple biology and pharmacological function. However, the role of Allicin, in the regulation of metabolic organ, especially the role of activation of BAT, has not been well studied. Here, we analyzed the role of Allicin in whole-body metabolism and the activation of BAT.Results:Allicin had a significant effect in inhibiting body weight gain, decreasing adiposity, maintaining glucose homeostasis, improving insulin resistance, and ameliorating hepatic steatosis in diet-introduced obesity (DIO) mice. Then we find that Allicin can strongly activate brown adipose tissue (BAT). The activation of brown adipocyte treated with Allicin was also confirmed in mouse primary brown adipocytes.Conclusion:Allicin can ameliorate obesity through activating brown adipose tissue. Our findings provide a promising therapeutic approach for the treatment of obesity and metabolic disorders.

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“…In CHD, research suggests that obese patients with myocardium are more susceptible to ischemia compared to nonobese people, with enhanced levels of ROS and ROS-producing enzymes (i.e., p47phox, xanthine oxidase) and reduced antioxidant activity (mitochondrial aldehyde dehydrogenase and heme oxygenase-1) [84]. In depression, obese mice fed with high-fat diet had severe depressive behaviors, which could be reversed by ondansetron treatment via restoration of brain prooxidant/antioxidant balance [85] and by allicin via activation of the Nrf2 pathway [86]. Apart from preclinical investigations, human studies have indicated that postpartum depression affects one in seven women, and obese women have an increased risk of depression through neurooxidation and neuronitrosation [87,88].…”

Section: Oxidative Stress and Risk Factorsmentioning

confidence: 99%

The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression

Lin

Wang

Yan

et al. 2019

Oxidative Medicine and Cellular Longevity

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The public health sector faces a huge challenge as a result of the high prevalence and burden of disability caused by ischemic cardio-cerebrovascular disease (CVD) and depression. Although studies have explored the underlying mechanisms and potential therapies to address conditions, there is no treatment breakthrough, especially for depression which is highly influenced by social stressors. However, accumulating evidence reveals that CVD and depression are correlated and share common risk factors, particularly obesity, diabetes, and hypertension. They also share common mechanisms, including oxidative stress (OS), inflammation and immune response, cell death signaling pathway, and microbiome-gut-brain axis. This review summarizes the relationship between ischemic CVD and depression and describes the interactions among common risk factors and mechanisms for these two diseases. In addition, we propose that OS mediates the crosstalk between these diseases. We also reveal the potential of antioxidants to ameliorate OS-related injuries.

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Allicin ameliorates obesity comorbid depressive-like behaviors: involvement of the oxidative stress, mitochondrial function, autophagy, insulin resistance and NOX/Nrf2 imbalance in mice

Cited by 35 publications

References 68 publications

Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

Allicin Regulates Energy Homeostasis through Brown Adipose Tissue

Allicin regulates energy homeostasis through brown adipose tissue

The Role of Oxidative Stress in Common Risk Factors and Mechanisms of Cardio-Cerebrovascular Ischemia and Depression

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