The suitability of using milled sunflower husks as a wood substitute for producing medium-density particleboard was investigated. Additionally, the impact of the adhesive type and the amount used on the properties of the panels were evaluated. Urea-formaldehyde (UF) in three commercial variants (UCL, U96, and AG), phenol-formaldehyde (PF), modified melamine urea-formaldehyde (VM), and polymeric diphenylmethane diisocyanate (pMDI), as well as mixtures of VM/AG and of PF/pMDI, were used to manufacture the panels. The adhesive content was varied between 3% and 6% for pMDI, and from 9% and 12% for the other adhesives. Higher thickness swelling (TS) and water absorption (WA) values were observed with the UF panels compared with the PF and pMDI panels. The lowest mechanical strength properties were observed for the UF panels, with the commercial variants ranking (from highest to lowest): UCL > VM/AG > U96. Increasing the adhesive content level resulted in better dimensional stabilities and mechanical properties for the pMDI and PF panels, which met some of the performance requirements for interior uses prescribed by the relevant standard.