Alleviative Effects of Quercetin and Onion on Male Reproductive Toxicity Induced by Diesel Exhaust Particles

Izawa, Hiromi; Kohara, Machiko; Aizawa, Koichi; Suganuma, Hiroyuki; Inakuma, Takahiro; Watanabe, Gen; Taya, Kazuyoshi; Sagai, Masaru

doi:10.1271/bbb.70705

Cited by 47 publications

(48 citation statements)

References 38 publications

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“…Similarly, it was reported that tubular diameter was increased by Q treatment in a dose dependent manner [Taepongsorat et al 2008]. In addition, Q inhibited diesel exhaust particles (DEPs) and arsenic induced testicular damage [Izawa et al 2008;Jahan et al 2014].…”

Section: Discussionmentioning

confidence: 98%

Therapeutic effects of quercetin against bisphenol A induced testicular damage in male Sprague Dawley rats

Jahan

Ain

Ullah

2016

Systems Biology in Reproductive Medicine

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The present study was designed to investigate protective effects of quercetin against bisphenol A (BPA) induced testicular toxicity in male Sprague Dawley rats. Twenty adult male rats were divided into four groups. The first group served as the control and was provided with normal saline. The second group of rats was treated with 50 mg/kg of BPA dissolved in alcoholic saline. The third group received oral gavage of 50 mg/kg quercetin while the fourth group was treated with quercetin (50 mg/kg) along with BPA (50 mg/kg). All of the treatments were carried out for 52 days. Testicular tissues and epididymis were used for histology while blood plasma was used for hormonal and biochemical analysis. BPA administration resulted in a significant reduction in seminiferous tubule diameter and epithelial height with impaired spermatogenesis. Quercetin treatment resulted in restoration of spermatogenesis and reversal of histological damage. In addition, BPA treatment significantly reduced (p < 0.05) plasma testosterone level (ng/ml) while estrogen was not affected. Similarly, BPA caused a significant alteration in the lipid profile. Interestingly, quercetin treatment led to a marked increase in plasma testosterone, decrease in estrogen concentration, as well as a normalized lipid profile. In conclusion, results indicated that BPA administration induces toxic effects on testis and epididymis, impairs spermatogenesis, with an imbalance in hormonal levels and lipid profile while quercetin amended these toxic effects by restoring normal spermatogenesis, testicular tissue damage, and hormonal levels. This suggests that quercetin may be a potential therapeutic against BPA induced testicular toxicity. ARTICLE HISTORY

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Section: Discussionmentioning

confidence: 98%

Therapeutic effects of quercetin against bisphenol A induced testicular damage in male Sprague Dawley rats

Jahan

Ain

Ullah

2016

Systems Biology in Reproductive Medicine

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“…However, it is known that some researchers have shown that onion contains exogenous and endogenous antioxidants such as selenium, glutathione, vitamins A, B, and C and flavonoids such as quercetin and isorhamnetin (Griffiths et al, 2002). These antioxidants protect DNA and other important molecules from oxidation and damage, which would otherwise induce apoptosis, and could improve sperm health parameters, increasing the rate of fertility in men (Hunt et al, 1992;Izawa et al, 2008). Khaki et al (2008) also demonstrated that the administration of onion juice (1 g/rat/day) for 20 days increases sperm count, viability, and motility in rats.…”

Section: Discussionmentioning

confidence: 99%

Semen quality characteristics of Koekoek breeder cocks influenced by supplemental inclusion levels of onion and garlic mixture at 35-41 weeks of age

Okoro

Mbajiorgu

2016

R. Bras. Zootec.

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-An experiment was conducted to determine the effect of varying dietary supplemental inclusion levels of onion and garlic mixture on semen quality characteristics of Koekoek breeder cocks aged 35-41 weeks. The experimental diets were isocaloric and isonitrogenous but with different supplemental inclusion levels of onion and garlic. A complete randomized design was used for the experiment. The three dietary supplemental levels based on garlic and onion supplemental inclusion levels were Q 0 (0 g onion and 0 g garlic per 600 g DM feed), Q 1 (2.5 g onion and 2.5 g garlic per 600 g DM feed), and Q 2 (5 g onion and 5 g garlic per 600 g DM feed) with each treatment having three replicates. A quadratic type equation was used to determine the onion and garlic levels for optimum semen quality characteristics. Daily supplementation with 5 g onion and 5 g garlic per 600 g DM feed increased progressive motile cells (%), actual life sperm count (×10 6 /nl), and live sperm (%) by 221.20%, 301.51%, and 352.43%, while 2.5 g onion and 2.5 g garlic per 600 g DM feed reduced them by 28.67%, 12.69%, and 19.00%, respectively. However, daily supplementation with 2.5 g onion and 2.5 g garlic per 600 g DM feed increased sperm count (×10 6 /nl) by 12.82%, whereas daily supplementation with 5 g onion and 5 g garlic per 600 g DM feed reduced it by 10.26% in Koekoek breeder cocks. Dietary onion and garlic supplemental inclusion levels of 3. 009, 3.191, 4.621, 6.601, 6.719, 2.327, 2.385, and 2.247 g per 600 g DM feed supported optimum progressive motile cells (%), immotile sperm cells (%), actual dead sperm count (×10 6 /nl), actual live sperm count (×10 6 /nl), live sperm (%), acrosome morphology defects (%), acrosome detachment (%), and acrosome swelling (%), with probability values ranging from 0.003 to 0.783, whereas minimum progressive motile cells (%) increase was achieved at an optimum onion and garlic supplementation levels of 3.009 g per 600 g DM feed. These findings have a lot of implications on the use of supplemental onion and garlic inclusion levels to enhance reproductive efficiency in Koekoek breeder cocks.

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“…Disrupting AhR signaling or expression therefore might reduce the expression of IL-6, which is known to have multiple roles in tumorigenesis. Some flavonoids present in plants have already been demonstrated to block ligand-activated AhR signaling and therefore these substances have potential therapeutic usefulness in cancer prevention (Fukuda et al, 2007;Izawa et al, 2008;Lu et al, 2008). Such flavonoids or other targeted drugs may be useful for the prevention or treatment of lung cancer patients where there is AhR involvement.…”

Section: Discussionmentioning

confidence: 99%

Aryl hydrocarbon receptor in association with RelA modulates IL-6 expression in non-smoking lung cancer

Chang

et al. 2011

Oncogene

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Alleviative Effects of Quercetin and Onion on Male Reproductive Toxicity Induced by Diesel Exhaust Particles

Cited by 47 publications

References 38 publications

Therapeutic effects of quercetin against bisphenol A induced testicular damage in male Sprague Dawley rats

Therapeutic effects of quercetin against bisphenol A induced testicular damage in male Sprague Dawley rats

Semen quality characteristics of Koekoek breeder cocks influenced by supplemental inclusion levels of onion and garlic mixture at 35-41 weeks of age

Aryl hydrocarbon receptor in association with RelA modulates IL-6 expression in non-smoking lung cancer

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