Alleviative Effects of Exercise on Bone Remodeling in Fluorosis Mice

Li, Rui; Gong, Zeen; Yu, Yanghuan; Niu, Ruiyan; Bian, Shengtai; Sun, Zilong

doi:10.1007/s12011-021-02741-y

Cited by 11 publications

(6 citation statements)

References 61 publications

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“…Similar studies by Wei et al (22) discovered that the femoral cancellous bone exhibited substantial bone resorption, as shown by significant thinning and irregularity of the bone trabeculae. Analysis shows that the histopathology of normal and osteoporotic bones reported that patients with osteoporosis had cortical effacement and a decrease in the density and integrity of trabecular bone (23). According to reports, the pathogenesis of GIOP generates a free radical that affects the compromise between bone growth and resorption (24).…”

Section: Discussionmentioning

confidence: 99%

“…Adult male BALB/c mice (Mus musculus) were used in all experiments. Animals with an average body weight of 33-35 g were purchased from the National Research Center (NRC, Cairo, Egypt), housed in polypropylene cages (6 animals/cage) at a temperature of (22)(23)(24)(25) ᵒC under 12:12 h day/night cycles, and supplied with a standard laboratory diet and water ad libitum. All experimental techniques were conducted by international animal care standards and used in laboratories.…”

Section: Animalsmentioning

confidence: 99%

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Histopathological examination of Allolobophora calignosa efficacy against glucocorticoid-induced osteoporosis in mice

Abdelfattah¹,

Mohamed²,

Ibrahim³

et al. 2023

GSC Biol. Pharm. Sci.

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Osteoporosis is a disease characterized by low bone mass, deterioration of bone tissue, and disruption of bone microarchitecture: it can lead to compromised bone strength and increased risk of fractures. Secondary osteoporosis is mostly glucocorticoid-induced osteoporosis (GIOP). According to traditional Chinese medicine, the kidney influences bone, and bone loss are associated with kidney and liver inadequacies. We tested Allolobophora caliginosa extract (EE) and Allolobophora caliginosa coelomic fluid (CF) for anti-osteoporotic activity against GIOP. 28 male mice were separated randomly into two groups; the control received distilled water, and the second group received 1 mg/kg dexamethasone daily for 28 days. The second group was divided randomly into three groups. The first OP subgroup received distilled water orally every other day for 28 days. The other two OP subgroups received EE (45 mg/kg body weight) and CF (20 mg/kg) orally for 28 days. EE and CF preserved cortical and trabecular bone loss, decreased bone marrow space, and enhanced chondrocyte production. EE and CF maintained hepatic necrosis in the liver and decreased renal degeneration in the kidney caused by GIOP. In this study, Histological images showed that EE at 45 mg/kg was highly effective as an anti-osteoporotic against GIOP, while CF at 20 mg/kg was moderately effective.

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Section: Discussionmentioning

confidence: 99%

Section: Animalsmentioning

confidence: 99%

Histopathological examination of Allolobophora calignosa efficacy against glucocorticoid-induced osteoporosis in mice

Abdelfattah¹,

Mohamed²,

Ibrahim³

et al. 2023

GSC Biol. Pharm. Sci.

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“…However, endurance running can promote the bone growth and development of CKD rats in the growth phase and can increase the expression of RANKL in the epiphyseal growth plate, with a certain therapeutic effect [ 72 ]. Fluoride poisoning can lead to skeletal fluorosis, causing oxidative stress damage to bone tissue, in turn leading to osteomalacia or OP, thereby damaging bone tissue [ 73 ]. Li et al [ 73 ] found that each mRNA and protein level in the OPG/RANKL/RANK signaling pathway was increased in fluoride-poisoned mice, which accelerated bone turnover and destroyed bone remodeling.…”

Section: Endurance Exercise and Bonementioning

confidence: 99%

“…Fluoride poisoning can lead to skeletal fluorosis, causing oxidative stress damage to bone tissue, in turn leading to osteomalacia or OP, thereby damaging bone tissue [ 73 ]. Li et al [ 73 ] found that each mRNA and protein level in the OPG/RANKL/RANK signaling pathway was increased in fluoride-poisoned mice, which accelerated bone turnover and destroyed bone remodeling. Interestingly, exercise intervention did not directly increase OPG expression, and it might play a therapeutic role by eliminating excessive fluoride and indirectly regulating the OPG/RANKL/RANK signaling pathway [ 73 ].…”

Section: Endurance Exercise and Bonementioning

confidence: 99%

“…Studies have shown that BAIBA signals through its receptor, Mas-related G protein-coupled receptor type D (MRGPRD), to inhibit mitochondrial breakdown in osteocytes, thereby protecting osteocytes from ROS-induced apoptosis [ 173 ]. In addition, among bone health problems caused by some special factors, such as fluorosis [ 73 ] and manganese superoxide dismutase (SOD2) deficiency [ 174 ], aerobic exercise has also been confirmed to play a therapeutic role and to protect bone from oxidative stress damage. Recent studies have shown that epigenetic changes are closely related to the pathogenesis of OP.…”

Section: Redox Reactions Mediate Motility and Regulate Bone Homeostasismentioning

confidence: 99%

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The Role of Oxidative Stress in Multiple Exercise-Regulated Bone Homeostasis

Gao¹,

Zhao²,

Zhao³

et al. 2023

Aging and disease

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Bone is a tissue that is active throughout the lifespan, and its physiological activities, such as growth, development, absorption, and formation, are always ongoing. All types of stimulation that occur in sports play an important role in regulating the physiological activities of bone. Here, we track the latest research progress locally and abroad, summarize the recent, relevant research results, and systematically summarize the effects of different types of exercise on bone mass, bone strength and bone metabolism. We found that different types of exercise have different effects on bone health due to their unique technical characteristics. Oxidative stress is an important mechanism mediating the exercise regulation of bone homeostasis. Excessive high-intensity exercise does not benefit bone health but induces a high level of oxidative stress in the body, which has a negative impact on bone tissue. Regular moderate exercise can improve the body's antioxidant defense ability, inhibit an excessive oxidative stress response, promote the positive balance of bone metabolism, delay age-related bone loss and deterioration of bone microstructures and have a prevention and treatment effect on osteoporosis caused by many factors. Based on the above findings, we provide evidence for the role of exercise in the prevention and treatment of bone diseases. This study provides a systematic basis for clinicians and professionals to reasonably formulate exercise prescriptions and provides exercise guidance for patients and the general public. This study also provides a reference for follow-up research.

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