Alleviative effects of deep-seawater drinking water on hepatic lipid accumulation and oxidation induced by a high-fat diet

Chen, I-Shu; Chang, Yu Shan; Hsu, Chin‐Lin; Lin, Hui-Wen; Chang, Ming-Hsu; Chen, Jr-Wei; Chen, Sheng-Shih; Chen, Yi‐Chen

doi:10.1016/j.jcma.2012.10.008

Cited by 26 publications

(27 citation statements)

References 27 publications

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“…In particular, drinking of DSW with high levels of Mg reduced serum lipids [32] and alleviated hepatic lipid accumulation and oxidation induced by high-fat diet [11] [33]. We also found that BDSW suppressed circulating triglycerides levels, except total cholesterol level, in the liver of STZ induced diabetic mice.…”

Section: Discussionmentioning

confidence: 53%

Modulation of Glucose Metabolism by Balanced Deep-Sea Water Ameliorates Hyperglycemia and Pancreatic Function in Streptozotocin-Induced Diabetic Mice

Park

Shin

et al. 2014

PLoS ONE

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The aim of this study was to determine the effects of balanced deep-sea water (BDSW) on hyperglycemia and glucose intolerance in streptozotocin (STZ)-induced diabetic mice. BDSW was prepared by mixing DSW mineral extracts and desalinated water to yield a final hardness of 1000–4000 ppm. Male ICR mice were assigned to 6 groups; mice in each group were given tap water (normal and STZ diabetic groups) or STZ with BDSW of varying hardness (0, 1000, 2000, and 4000 ppm) for 4 weeks. The STZ with BDSW group exhibited lowered fasting plasma glucose levels than the STZ-induced diabetic group. Oral glucose tolerance tests showed that BDSW improves impaired glucose tolerance in STZ-induced diabetic mice. Histopathological evaluation of the pancreas showed that BDSW restores the morphology of the pancreatic islets of Langerhans and increases the secretion of insulin in STZ-induced diabetic mice. Quantitative real-time PCR assay revealed that the expression of hepatic genes involved in gluconeogenesis, glucose oxidation, and glycogenolysis was suppressed, while the expression of the genes involved in glucose uptake, β-oxidation, and glucose oxidation in muscle were increased in the STZ with BDSW group. BDSW stimulated PI3-K, AMPK, and mTOR pathway-mediated glucose uptake in C2C12 myotubes. BDSW increased AMPK phosphorylation in C2C12 myotubes and improved impaired AMPK phosphorylation in the muscles of STZ-induced diabetic mice. Taken together, these results suggest that BDSW is a potential anti-diabetic agent, owing to its ability to suppress hyperglycemia and improve glucose intolerance by modulating glucose metabolism, recovering pancreatic islets of Langerhans and increasing glucose uptake.

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Section: Discussionmentioning

confidence: 53%

Modulation of Glucose Metabolism by Balanced Deep-Sea Water Ameliorates Hyperglycemia and Pancreatic Function in Streptozotocin-Induced Diabetic Mice

Park

Shin

et al. 2014

PLoS ONE

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“…DSW consumption lowers the lipid profile, levels of serum thiobarbituric acid-reactive substances, and lipid peroxidation levels in hypercholesterolemic subjects and increases antioxidant enzyme glutathione peroxidase-1 activity [4], [5], [28], possibly due to its high Mg 2+ and Ca 2+ content. Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin [29].…”

Section: Discussionmentioning

confidence: 99%

Deep-Sea Water Containing Selenium Provides Intestinal Protection against Duodenal Ulcers through the Upregulation of Bcl-2 and Thioredoxin Reductase 1

Yang

Yao

Lin³

et al. 2014

PLoS ONE

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Deep-sea water (DSW), which is rich in micronutrients and minerals and with antioxidant and anti-inflammatory qualities, may be developed as marine drugs to provide intestinal protection against duodenal ulcers. We determined several characteristics in the modified DSW. We explored duodenal pressure, oxygenation, microvascular blood flow, and changes in pH and oxidative redox potential (ORP) values within the stomach and duodenum in response to tap water (TW, hardness: 2.48 ppm), DSW600 (hardness: 600 ppm), and DSW1200 (hardness: 1200 ppm) in Wistar rats and analyzed oxidative stress and apoptosis gene expressions by cDNA and RNA microarrays in the duodenal epithelium. We compared the effects of drinking DSW, MgCl2, and selenium water on duodenal ulcers using pathologic scoring, immunohistochemical analysis, and Western blotting. Our results showed DSW has a higher pH value, lower ORP value, higher scavenging H2O2 and HOCl activity, higher Mg2+ concentrations, and micronutrients selenium compared with TW samples. Water infusion significantly increased intestinal pressure, O2 levels, and microvascular blood flow in DSW and TW groups. Microarray showed DSW600, DSW1200, selenium water upregulated antioxidant and anti-apoptotic genes and downregulated pro-apoptotic gene expression compared with the TW group. Drinking DSW600, DSW1200, and selenium water but not Mg2+ water significantly enhanced Bcl-2 and thioredoxin reductase 1 expression. Bax/Bcl-2/caspase 3/poly-(ADP-ribose)-polymerase signaling was activated during the pathogenesis of duodenal ulceration. DSW drinking reduced ulcer area as well as apoptotic signaling in acetic acid-induced duodenal ulcers. DSW, which contains selenium, provides intestinal protection against duodenal ulcers through the upregulation of Bcl-2 and thioredoxin reductase 1.

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“…DSW is able to give protection for hepatic problems. In a study by Chen et al [33], it has decreased the lipid accumulation in livers, which are associated with the increase in daily faecal lipid and bile acid outputs. The hepatic antioxidative levels were also improved by its application, which were proven by the high capacity levels of liver glutathione and trolox equivalent antioxidant.…”

Section: Potential Benefits Of Deep Sea Water To Healthmentioning

confidence: 99%

“…DSW was able to regulate hepatic fatty acid homeostasis by upregulating genes related to b-oxidation of fatty acids, which are hepatic peroxisome proliferator-activated receptor-alpha, retinoid X receptor-alpha, and uncoupling protein-2 gene expression. Its application can attenuate hepatic damage, which is proven by reduced lipid peroxidation status in livers, which might be related to reducing hepatic malondialdehyde (MDA) content [33]. The liver damage indices which are aspartate aminotransferase (AST) and alanine aminotransferase (ALT) are also reduced by its application.…”

Section: Potential Benefits Of Deep Sea Water To Healthmentioning

confidence: 99%

Potential Health Benefits of Deep Sea Water: A Review

Nani

Majid

Jaafar

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Deep sea water (DSW) commonly refers to a body of seawater that is pumped up from a depth of over 200 m. It is usually associated with the following characteristics: low temperature, high purity, and being rich with nutrients, namely, beneficial elements, which include magnesium, calcium, potassium, chromium, selenium, zinc, and vanadium. Less photosynthesis of plant planktons, consumption of nutrients, and organic decomposition have caused lots of nutrients to remain there. Due to this, DSW has potential to become a good source for health. Research has proven that DSW can help overcome health problems especially related to lifestyle-associated diseases such as cardiovascular disease, diabetes, obesity, cancer, and skin problems. This paper reviews the potential health benefits of DSW by referring to the findings from previous researches.

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Alleviative effects of deep-seawater drinking water on hepatic lipid accumulation and oxidation induced by a high-fat diet

Abstract: DSW shows a preventive effect on development of hepatosteatosis induced by a high-fat diet.

Cited by 26 publications

References 27 publications

Modulation of Glucose Metabolism by Balanced Deep-Sea Water Ameliorates Hyperglycemia and Pancreatic Function in Streptozotocin-Induced Diabetic Mice

Modulation of Glucose Metabolism by Balanced Deep-Sea Water Ameliorates Hyperglycemia and Pancreatic Function in Streptozotocin-Induced Diabetic Mice

Deep-Sea Water Containing Selenium Provides Intestinal Protection against Duodenal Ulcers through the Upregulation of Bcl-2 and Thioredoxin Reductase 1

Potential Health Benefits of Deep Sea Water: A Review

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