Alleviation of silver nanoparticle-induced sexual behavior and testicular parameters dysfunction in male mice by yttrium oxide nanoparticles

Abu-Taweel, Gasem Mohammad; Albetran, Hani Manssor; Al-Mutary, Mohsen Ghaleb; Ahmad, Mohammad; Low, It Meng

doi:10.1016/j.toxrep.2021.05.014

Cited by 18 publications

(16 citation statements)

References 69 publications

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“…YO-NPs have been demonstrated to be a powerful element that can be applied for many biomedicine purposes [ 49 ]. We noted in our previous experiment that YO-NPs moderated the toxic effects of Ag-NPs on testicular function by improving oxidative parameters and decreasing apoptotic cells [ 50 ]. Schubert et al [ 51 ] mentioned the ability of the YO-NPs to protect nerve cells from oxidative stress.…”

Section: Discussionmentioning

confidence: 99%

Yttrium Oxide Nanoparticles Moderate the Abnormal Cognitive Behaviors in Male Mice Induced by Silver Nanoparticles

Abu-Taweel

Al-Mutary

Albetran

2022

Oxidative Medicine and Cellular Longevity

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Silver nanoparticles (Ag-NPs) have been used in medical, agricultural, and industrial purposes. Furthermore, NPs can cross the blood-brain barrier and encourage some effects on spatial learning and memory in organism. Here, we investigate the possible neurotoxicity of Ag-NPs with special emphasis on the neuroprotective impacts of yttrium-oxide nanoparticles (YO-NPs) in male mice. Male mice ( n = 24 ) were weekly intraperitoneally injected for 35 days as the following; groups I, II, III, and IV received tap water (control), Ag-NPs (40 mg/kg), YO-NPs (40 mg/kg), and Ag-NPs/YO-NPs (40 mg/kg each), respectively. After that, animals were tested in shuttle box, Morris water-maze, and T-maze devices to evaluate the spatial learning and memory competence. Neurotransmitters and oxidative indices in the forebrain were estimated. According to behavioral studies, the male animals from the Ag-NP group presented worse memory than those in the control group. The biochemical changes after Ag-NP exposure were observed through increasing TBARS levels and decline in oxidative biomarkers (SOD, CAT, GST, and GSH) and neurotransmitters (DOP, SER, and AChE) in the forebrain of male mice compared to untreated animals. Interestingly, the animals treated with mixed doses of Ag-NPs and YO-NPs displayed improvements in behavioral tests, oxidative parameters, and neurotransmitters compared to males treated with Ag-NPs alone. In conclusion, the abnormal behavior related to learning and memory in male mice induced by Ag-NPs was significantly alleviated by YO-NPs. Specifically, the coinjection of YO-NPs with Ag-NPs moderates the disruption in neurotransmitters, oxidative indices of mice brains, which reflects on their cognitive behaviors.

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Section: Discussionmentioning

confidence: 99%

Yttrium Oxide Nanoparticles Moderate the Abnormal Cognitive Behaviors in Male Mice Induced by Silver Nanoparticles

Abu-Taweel

Al-Mutary

Albetran

2022

Oxidative Medicine and Cellular Longevity

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“…MDA content in ELISA methods can be used to detect lipid peroxidation, which is one of the main indicators of oxidative stress (77,81,89). With commercial kits, GSH levels and total antioxidant capacities can be measured, as well as analyzed at the level of antioxidant biomolecules and enzymes such as CAT, SOD (83, 91,133).…”

Section: Experimental Methods For Assessing the Kesmentioning

confidence: 99%

“…In our database, the most reported of the biological events is Ag NPs exposure triggering oxidative stress, which is described in 22 out of the 48 articles at both cellular and tissue level. It has been shown that accumulation of Ag NPs depleted cells from the molecular antioxidant GSH (39,(75)(76)(77), and decreased super oxide dismutase (SOD) and catalase (CAT) activities (29,39,(77)(78)(79), altered enzymatic oxidative defense system in male reproductive system (29,38,39,77,80,81) and lead to increased ROS levels in human sperm (82), in mouse Sertoli cells (15P-1) (83), in somatic Leydig (TM3) and Sertoli (TM4) cells (36,84) which eventually cause oxidative stress. In addition, mitochondrial damage due to the impairment of metallothionein (MIE) would result in oxidative stress by inhibition of electron transfer chain enzymes and perturbation of antioxidant system.…”

Section: Identi Cation and Selection Of Key Eventsmentioning

confidence: 99%

“…Twenty-four out of the 48 identi ed studies analyzed sperm parameters after exposure to Ag-NPs, including sperm morphology, viability, motility, and DNA damage. Upon Ag NP exposure, abnormal sperm morphology, decreased sperm viability and motility, increased sperm DNA damage were reported in number of studies (38,75,77,79,86,90,109,127). The production of sperm requires a complex interaction between Sertoli, Leydig and germ cells.…”

Section: Identi Cation and Selection Of Key Eventsmentioning

confidence: 99%

“…Testis index and histological structure of testicular tissues, morphology, seminiferous tubule area, circumference, diameter and tubular degeneration/atrophy were the most studied parameters. A prominent atrophy of seminiferous tubules, thinning of the tubule wall, disorganization and vacuolization of germinal epithelium, and loss of spermatogenic cells in testis tissue of rats and mice exposed to Ag NPs are reported (39,77,80,84). In the interstitial tissue, Leydig cells are highly affected, presenting disrupted plasma membrane on extensive areas, with loss of cell organelles (80).…”

Section: Identi Cation and Selection Of Key Eventsmentioning

confidence: 99%

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Putative adverse outcome pathway for silver nanoparticle toxicity on male reproductive system: A literature review

Köse¹,

Mantecca

Costa

et al. 2022

Preprint

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Background: Adverse outcome pathways (AOPs) are conceptual frameworks that organize knowledge about biological interactions and toxicity mechanisms. They present a sequence of events commencing with initial interaction(s) of a stressor, which defines the perturbation in a biological system (molecular initiating event, MIE), and a dependent series of key events (KEs), ending with an adverse outcome (AO). AOPs have recently become the subject of intense studies in a view to better understand the mechanisms of nanomaterial (NM) toxicity. Silver nanoparticles (Ag NPs) are one of the most explored nanostructures and are extensively used in various application. This, in turn, has increased the potential for interactions of Ag NPs with environments, and toxicity to human health. The aim of this study was to construct a putative AOPs (pAOP) related to reproductive toxicity of Ag NPs, in order to lay the groundwork for a better comprehension of mechanism affecting both undesired toxicity (against human cell) and expected toxicity (against microorganisms). Methods: PubMed and Scopus were systematically searched for peer-reviewed studies examining reproductive toxicity potential of Ag NPs. The quality of selected studies was assessed through ToxRtool. Eventually, forty-eightstudies published between 2005 and 2022 were selected to identify the mechanisms of Ag NPs impact on reproductive function in male. The biological endpoints, measurements, and results were extracted from these studies. Where possible, endpoints were assigned to a potential KE and an AO using expert judgment. Then, KEs were classified at each major level of biological organization. Results: We identified the impairment of intracellular SH-containing biomolecules, which are major cellular antioxidants, as a putative MIE, with subsequent KEs defined as ROS accumulation, mitochondrial damage, DNA damage and lipid peroxidation, apoptosis, reduced production of reproductive hormones and reduced quality of sperm. These successive KEs may result in impaired male fertility (AO). Conclusion: This research recapitulates and schematically represents complex literature data gathered from different biological levels and propose a pAOP related to the reproductive toxicity induced by AgNPs. The development of AOPs specific to NMs should be encouraged in order to provide new insights to gain a better understanding of NP toxicity.

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Cu2O Nanoparticles Deposited on Y2O3 and CuO: Synthesis and Antimicrobial Properties

et al. 2022

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This paper reports the preparation of copper(I) oxide nanoparticles deposited on yttrium oxide and copper(II) oxide in the presence of acerola and white willow extracts. Through the use of natural compounds, it was possible to modify the surface of the Y2O3 and CuO carriers allowing Cu2O to be deposited to a greater extent, thus improving the antibacterial properties of the materials. Cu2O nanoparticles, by being deposited on a carrier, enable an increase in the contact surface of the nanoparticles with microorganisms, which react to form reactive oxygen species. Cu2O nanoparticles with sizes of about 38 nm and 76 nm were obtained for Y2O3- and CuO-deposited nanoparticles, respectively. The Gram-negative bacteria Escherichia coli shown a greater sensitivity to the degree of inhibition compared to Staphylococcus Aureus already at a concentration of 250 mg/L. For almost all materials, the inhibition level remained above 50% after 48 h. Analysis of the effect of the antimicrobial properties of the materials against Candida albicans fungus shown high activity which was obtained only at the highest concentrations of 8000 mg/L, for which the degree of growth inhibition was 100% also after 48 h for both Y2O3–Cu2O and CuO–Cu2O.

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Alleviation of silver nanoparticle-induced sexual behavior and testicular parameters dysfunction in male mice by yttrium oxide nanoparticles

Abstract: Graphical abstract Alleviation of silver nanoparticle-induced sexual behavior and testicular parameters dysfunction in male mice by yttrium oxide nanoparticles. Gasem Mohammad Abu-Taweel, Hani Manssor Albetran, Mohsen Ghaleb Al-Mutary, Mohammad Ahmad, It Meng Low.

Cited by 18 publications

References 69 publications

Yttrium Oxide Nanoparticles Moderate the Abnormal Cognitive Behaviors in Male Mice Induced by Silver Nanoparticles

Yttrium Oxide Nanoparticles Moderate the Abnormal Cognitive Behaviors in Male Mice Induced by Silver Nanoparticles

Putative adverse outcome pathway for silver nanoparticle toxicity on male reproductive system: A literature review

Cu2O Nanoparticles Deposited on Y2O3 and CuO: Synthesis and Antimicrobial Properties

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