Alleviation of experimental cyclosporin A nephrotoxicity by low dose aspirin in the rat

Vitamin E Pretreatment Prevents Cyclosporin A-lnduced Crystal Deposition in Hyperoxaluric Rats

“…This may be responsible for the observed increased excretion of oxalate in the CsAtreated group. Microcalcification in renal cells has been shown on prolonged administration of CsA for 14-21 days due to chronic tubular damage [11,12], The tubular injury seen in the present study may be mediated through LPO by the administration of CsA, since vitamin E pre treatment restores the activities of these marker enzymes in urine to near normal levels and also prevents crystal deposition in CsA coadministered hyperoxaluric rat kid ney. CsA-induced nephrotoxicity has been shown to be inhibited by vitamin E [13] and dietary supplementation of a lysine salt of eicosapentaenoic acid [14].…”

Influence of aspirin on early allograft thrombosis and chronic allograft nephropathy following renal transplantation

“…The current study suggests that aspirin at least partly reverses renal allograft thrombogenicity, regardless of its aetiology. This may be mediated by its anti-in¯ammatory and antithrombotic effects on renal eicosanoid production 22±24 , although reduced cyclosporin nephrotoxicity via a reduction in renal thromboxane synthesis may be signi®cant 24,25 . CAN, the leading cause of late renal transplant loss 8 , occurs in response to a combination of immunological and non-immunological factors (including ischaemia±reperfusion injury and choice of immunosuppression).…”

Toxicity and Drug Safety

“…Here, anti-inflammatory properties of aspirin as well as inhibition of thromboxane formation are probably therapeutically relevant [277][278][279]. This includes some types of glomerulonephritis, cyclosporine nephrotoxicity, and renal allograft function.…”